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PDBsum entry 1oll
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Immune system/receptor
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PDB id
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1oll
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Structure of the human nk cell triggering receptor nkp46 ectodomain.
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Authors
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M.Ponassi,
C.Cantoni,
R.Biassoni,
R.Conte,
A.Spallarossa,
A.Pesce,
A.Moretta,
L.Moretta,
M.Bolognesi,
D.Bordo.
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Ref.
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Biochem Biophys Res Commun, 2003,
309,
317-323.
[DOI no: ]
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PubMed id
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Abstract
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NKp46, a natural killer (NK) cell-specific receptor, has been recently
identified as one of the triggering receptors involved in NK cell activation
mediated by non-HLA class I ligands. The structure of the NKp46 extracellular
receptor region, here reported, consists of two Ig-like domains assembled
similarly to leukocyte immunoglobulin-like receptors (LIRs) and killer
inhibitory receptors (KIRs). The extensive NKp46 residue substitutions at sites
structurally related to those mediating interaction with HLA antigens in LIRs
and KIRs indicate that NKp46 recognition processes in vivo should involve
non-HLA ligands. NKP46 is shown to stem from an ancestral KIR/LIR family.
However, the absence of close paralogues, such as those found for LIR and KIR,
indicates that NKp46 is the unique member of a distinct Ig-like subfamily and
suggests a specific role, which appears to be maintained across primates and
rodents.
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