_EC 3.4.22.2 Papain. 26 PDB entries  
EC 3.-.-.- Hydrolases. [20,488 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,785 PDB entries]
EC 3.4.22.- Cysteine endopeptidases. [978 PDB entries]
EC 3.4.22.2 Papain. [26 PDB entries]    
1bp4

Reaction: Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1'.
Other name(s): Papaya peptidase I.
Comments: From latex of the papaya (Carica papaya). Inhibited by compound E-64 and proteins of the cystatin family. Belongs to peptidase family C1. Formerly Ec 3.4.4.10.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 26 PDB entries in enzyme class E.C.3.4.22.2

  PDB code Protein
1bp4
Use of papain as a model for the structure-based design of c inhibitors. Crystal structures of two papain inhibitor comp demonstrate binding to s'-subsites.
Source: Carica papaya. Papaya. Organism_taxid: 3649
Chain: A (212 residues) CATH domain: 3.90.70.10
1bqi
Use of papain as a model for the structure-based design of cathepsin k inhibitors. Crystal structures of two papain inhibitor complexes demonstrate binding to s'-subsites.
Source: Carica papaya. Papaya. Organism_taxid: 3649
Chain: A (212 residues) CATH domain: 3.90.70.10
1cvz
Crystal structure analysis of papain with clik148(cathepsin l specific inhibitor)
Source: Carica papaya. Papaya. Organism_taxid: 3649
Chain: A (212 residues) CATH domain: 3.90.70.10
1eff
Knowledge based model of an inhibitor bound to a thiol(cystein) protease, papain complexed with napqi
Source: Carica papaya. Papaya. Organ: fruit. Secretion: latex
Chain: A (212 residues)
1khp
Monoclinic form of papain/zlfg-dam covalent complex
Source: Carica papaya. Papaya. Organism_taxid: 3649. Synthetic: yes
Chain: A (212 residues) CATH domain: 3.90.70.10
1khq
Orthorhombic form of papain/zlfg-dam covalent complex
Source: Carica papaya. Papaya. Organism_taxid: 3649. Synthetic: yes
Chain: A (212 residues) CATH domain: 3.90.70.10
1pad
Binding of chloromethyl ketone substrate analogues to crysta papain
Source: Carica papaya. Papaya. Organism_taxid: 3649. Tissue: fruit latex. Synthetic: yes
Chain: A (212 residues) CATH domain: 3.90.70.10
1pe6
Refined x-ray structure of papain(dot)e-64-c complex at 2.1- resolution
Source: Carica papaya. Papaya. Organism_taxid: 3649
Chain: A (212 residues) CATH domain: 3.90.70.10
1pip
Crystal structure of papain-succinyl-gln-val-val-ala-ala-p- nitroanilide complex at 1.7 angstroms resolution: noncovale mode of a common sequence of endogenous thiol protease inhi
Source: Carica papaya. Papaya. Organism_taxid: 3649. Synthetic: yes
Chain: A (212 residues) CATH domain: 3.90.70.10
1pop
X-ray crystallographic structure of a papain-leupeptin compl
Source: Carica papaya. Papaya. Organism_taxid: 3649. Streptomyces roseus. Organism_taxid: 66430. Strain: ma 839-a1
Chain: A (212 residues) CATH domain: 3.90.70.10
1ppd
Restrained least-squares refinement of the sulfhydryl protease papain to 2.0 angstroms
Source: Carica papaya. Papaya. Organism_taxid: 3649
Chain: A (212 residues) CATH domain: 3.90.70.10
1ppn
Structure of monoclinic papain at 1.60 angstroms resolution
Source: Carica papaya. Papaya. Organism_taxid: 3649
Chain: A (212 residues) CATH domain: 3.90.70.10
1ppp
Crystal structure of papain-e64-c complex. Binding diversity to papain s2 and s3 subsites
Source: Carica papaya. Papaya. Organism_taxid: 3649
Chain: A (212 residues) CATH domain: 3.90.70.10
1stf
The refined 2.4 angstroms x-ray crystal structure of recombinant human stefin b in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction
Source: Carica papaya. Papaya. Organism_taxid: 3649. Organ: fruit. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.
Chain: E (212 residues) CATH domain: 3.90.70.10
2cio
The high resolution x-ray structure of papain complexed with fragments of the trypanosoma brucei cysteine protease inhibitor icp.
Source: Carica papaya. Organism_taxid: 3649. Other_details: purchased from sigma. Trypanosoma brucei. Organism_taxid: 5691. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (212 residues) CATH domain: 3.90.70.10
2pad
Binding of chloromethyl ketone substrate analogues to crysta papain
Source: Carica papaya. Papaya. Organism_taxid: 3649
Chain: A (212 residues) CATH domain: 3.90.70.10
3e1z
Crystal structure of the parasite protesase inhibitor chagasin in complex with papain
Source: Trypanosoma cruzi. Organism_taxid: 5693. Gene: cha. Expressed in: escherichia coli. Expression_system_taxid: 562. Carica papaya. Papaya. Organism_taxid: 3649. Strain: papaya
Chain: B (212 residues) CATH domain: 3.90.70.10
3ima
Complex strcuture of tarocystatin and papain
Source: Carica papaya. Mamon. Organism_taxid: 3649. Other_details: papain was purchased from sigma co. For co- crystallization with cecpi.. Colocasia esculenta. Cocoyam,dasheen,eddo,elephant's ear,kalo, malanga. Organism_taxid: 4460.
Chains: A, C (212 residues) CATH domain: 3.90.70.10
3lfy
Ctd of tarocystatin in complex with papain
Source: Carica papaya. Mamon. Organism_taxid: 3649. Other_details: papain was purchased from sigma co. For co- crystallization.
Chains: A, C (212 residues) CATH domain: 3.90.70.10
3tnx
Structure of the precursor of a thermostable variant of papa angstroem resolution
Source: Carica papaya. Mamon. Organism_taxid: 3649. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C (310 residues) CATH domain: 3.90.70.10
3usv
Structure of the precursor of a thermostable variant of papa a resolution from a crystal soaked at ph 4
Source: Carica papaya. Mamon. Organism_taxid: 3649. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C (308 residues) CATH domain: 3.90.70.10
4kp9
Crystal structure of papain modify by achiral ru(ii)complex
Source: Carica papaya. Mamon. Organism_taxid: 3649. Organism_taxid: 3649
Chains: A, B (213 residues)
4pad
Binding of chloromethyl ketone substrate analogues to crysta papain
Source: Carica papaya. Papaya. Organism_taxid: 3649
Chain: A (212 residues) CATH domain: 3.90.70.10
5pad
Binding of chloromethyl ketone substrate analogues to crysta papain
Source: Carica papaya. Papaya. Organism_taxid: 3649. Tissue: fruit latex. Synthetic: yes
Chain: A (212 residues) CATH domain: 3.90.70.10
6pad
Binding of chloromethyl ketone substrate analogues to crysta papain
Source: Carica papaya. Papaya. Organism_taxid: 3649. Tissue: fruit latex
Chain: A (212 residues) CATH domain: 3.90.70.10
9pap
Structure of papain refined at 1.65 angstroms resolution
Source: Carica papaya. Papaya. Organism_taxid: 3649
Chain: A (212 residues) CATH domain: 3.90.70.10