EC 3.4.22.2 - Papain

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IntEnz Enzyme Nomenclature
EC 3.4.22.2

Names

Accepted name:
papain
Other names:
Papaya peptidase I
papaine
papayotin
summetrin
velardon
Systematic name:
-

Reaction

Comments:

Type example of peptidase family C1 from latex of the papaya (Carica papaya) fruit. Inhibited by compound E-64 and proteins of the cystatin family. Formerly EC 3.4.4.10.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00126
Structural data: CSA , EC2PDB
CAS Registry Number: 9001-73-4
UniProtKB/Swiss-Prot:

References

  1. Kamphuis, I.G., Drenth, J. and Baker, E.N.
    Thiol proteases. Comparative studies based on the high-resolution structures of papain and actinidin, and on amino acid sequence information for cathepsins B and H, and stem bromelain.
    J. Mol. Biol. 182: 317-329 (1985). [PMID: 3889350]
  2. Ménard, R. and Storer, A.C.
    Papain.
    In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.) Handbook of Proteolytic Enzymes, Academic Press, London, 1998, 555-557

[EC 3.4.22.2 created 1961 as EC 3.4.4.10, transferred 1972 to EC 3.4.22.2, modified 1976, modified 2000]