Ligand clusters for UniProt code Q07889

Ligand clusters for Q07889: Son of sevenless homolog 1 from Homo sapiens

		Top 6 (of 24) ligand clusters Cluster 1. 58 ligand types 69 ligands Cluster 2. 4 ligand types 4 ligands Cluster 3. 2 ligand types 2 ligands Cluster 4. 2 ligand types 2 ligands Cluster 5. 3 ligand types 28 ligands Cluster 6. 2 ligand types 6 ligands
Representative protein: 4nyiS

Structures

PDB		Schematic diagram
4nyiS
1nvwS
5ovhA
1nvvS
1nvuS
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Cluster 1 contains 58 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: GOL × 2 glycerin Glycerol PDB codes: 6d5e(B), 6d5g(B).
		2. Ligand: IMD × 8 Imidazole PDB codes: 6scm(A), 6sfr(A), 7avl(A), 7avs(A), 7avt(A), 7avv(A).
		3. Ligand: EDO × 3 1,2-Ethanediol PDB codes: 5ovd(A), 5ovf(A), 5ovi(A).
		4. Ligand: BPW × 2 3-(4-Chlorophenyl)propan-1-Amine PDB codes: 6epo(S),
		5. Ligand: 2PX × 1 N-{1-[(5-Methyl-1h-Indol-3-Yl)methyl]piperidin-4-Yl}-L- Tryptophanamide PDB code: 4nyi(S).
		6. Ligand: 2PZ × 1 N-[1-(1h-Indol-3-Ylmethyl)piperidin-4-Yl]glycinamide PDB code: 4nyj(S).
		7. Ligand: 5UU × 1 6-Chloranyl-~{N}-(4-Fluorophenyl)-1,2,3,4- Tetrahydroacridin-9-Amine PDB code: 5wfo(N).
		8. Ligand: 5UV × 1 7-Chloranyl-~{N}-(3-Chloranyl-4-Fluoranyl-Phenyl)-1,2, 3,4-Tetrahydroacridin-9-Amine PDB code: 5wfq(N).
		9. Ligand: 5UW × 1 ~{N}-(3,3-Diphenylpropyl)piperidin-4-Amine PDB code: 5wfr(N).
		10. Ligand: 5UX × 1 6-Chloranyl-~{N}-(3-Chloranyl-4-Fluoranyl-Phenyl)-1,2, 3,4-Tetrahydroacridin-9-Amine PDB code: 5wfp(N).
		11. Ligand: 6W2 × 1 4-Methoxy-N-(1,3-Thiazol-2-Yl)benzenesulfonamide PDB code: 4uru(S).
		12. Ligand: AWT × 1 6,7-Dimethoxy-2-Methyl-~{N}-[(1~{r})-1-[3-(1~{h}- Pyrazol-4-Yl)phenyl]ethyl]quinazolin-4-Amine PDB code: 5ovf(A).
		13. Ligand: AWW × 1 [2-[5-[(1~{r})-1-[(6,7-Dimethoxy-2-Methyl-5,8- Dihydroquinazolin-4-Yl)amino]ethyl]thiophen-2- Yl]phenyl]methanol PDB code: 5ovh(A).
		14. Ligand: AWZ × 1 ~{N}-[(1~{r})-1-[5-(6,7-Dihydro-5~{h}-Pyrrolo[1,2- A]imidazol-3-Yl)thiophen-2-Yl]ethyl]-6,7- Dimethoxy-2- Methyl-Quinazolin-4-Amine PDB code: 5ovg(A).
		15. Ligand: AXE × 1 6,7-Dimethoxy-~{N}-[(1~{r})-1-Naphthalen-1- Ylethyl]quinazolin-4-Amine PDB code: 5ove(A).
		16. Ligand: AXH × 1 6,7-Dimethoxy-2-Methyl-~{N}-[(1~{r})-1-[4-[2- (Methylaminomethyl)phenyl]thiophen-2- Yl]ethyl]quinazolin-4-Amine PDB code: 5ovi(A).
		17. Ligand: BOQ × 1 Ethyl 2-(Aminomethyl)-5-~{Tert}-Butyl-Furan-3- Carboxylate PDB code: 6epp(S).
		18. Ligand: BQ2 × 1 1-(3,4-Dihydro-1~{h}-Isoquinolin-2-Yl)-2-Oxidanyl- Ethanone PDB code: 6epn(S).
		19. Ligand: BQ5 × 1 (1-Phenyl-5,6-Dihydro-4~{h}-Cyclopenta[c]pyrazol-3-Yl) methanamine PDB code: 6epm(S).
		20. Ligand: DXO × 1 2-(2,6-Dimethylphenyl)-4-(Methylsulfanyl)-6- (Piperazin-1-Yl)-1,3,5-Triazine PDB code: 4urw(S).
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Cluster 2 contains 4 ligand types

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Ligand		Description
		1. Ligand: LBK × 1 6,7-Dimethoxy-~{N}-[(1~{r})-1-Phenylethyl]quinazolin-4- Amine PDB code: 6sfr(A).
		2. Ligand: S3Q × 1 6,7-Dimethoxy-2-Methyl-~{N}-[(1~{r})-1-[3- (Trifluoromethyl)phenyl]ethyl]quinazolin-4-Amine PDB code: 7avs(A).
		3. Ligand: S3T × 1 ~{N}-[(1~{r})-1-(3-Aminophenyl)ethyl]-6,7-Dimethoxy-2- Methyl-Quinazolin-4-Amine PDB code: 7avt(A).
		4. Ligand: S3Z × 1 ~{N}-[(1~{r})-1-[3-Azanyl-5-(Trifluoromethyl) phenyl]ethyl]-6,7-Dimethoxy-2-Methyl-Quinazolin-4- Amine PDB code: 7avu(A).

Cluster 3 contains 2 ligand types

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Ligand		Description
		1. Ligand: L71 × 1 (3s)-3-[3-(Aminomethyl)phenyl]-1- Ethylpyrrolidine-2,5-Dione PDB code: 4us1(S).
		2. Ligand: L7S × 1 3-[(3r)-1-Ethyl-2,5-Dioxopyrrolidin-3-Yl] benzamide PDB code: 4us2(S).

Cluster 4 contains 2 ligand types

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Ligand		Description
		1. Ligand: RV1 × 1 N-[(4-Aminophenyl)sulfonyl]cyclopropanecarboxamide PDB code: 4ury(S).
		2. Ligand: VJP × 1 1-[(4-Aminophenyl)sulfonyl]piperidin-2-One PDB code: 4urz(S).

Cluster 5 contains 3 ligand types

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Ligand		Description
		1. Ligand: GOL × 23 glycerin Glycerol PDB codes: 6bvi(B), 6bvj(B), 6bvk(B), 6bvl(B), 6bvm(B), 6cuo(B), 6cup(B), 6cur(B), 6d55(B), 6d56(B), 6d59(B), 6d5e(B), 6d5g(B), 6d5h(B), 6d5j(B), 6d5l(B), 6v94(B), 6v9f(B), 6v9j(B), 6v9l(B), 6v9m(B), 6v9n(B), 6v9o(B).
		2. Ligand: EDO × 4 1,2-Ethanediol PDB codes: 5ovd(A), 5ove(A), 5ovg(A), 5ovi(A).
		3. Ligand: RV1 × 1 N-[(4-Aminophenyl)sulfonyl]cyclopropanecarboxamide PDB code: 4ury(S).

Cluster 6 contains 2 ligand types

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Ligand		Description
		1. Ligand: PO4 × 5 Phosphate ion PDB codes: 1nvu(S), 1nvv(S), 1nvw(S), 1xd2(C).
		2. Ligand: QTA × 1 3-(Phenylsulfonyl)benzene-1-Sulfonamide PDB code: 6v9o(B).