Ligand clusters for UniProt code P08473

Ligand clusters for P08473: Neprilysin OS=Homo sapiens GN=MME PE=1 SV=2

		Top 6 (of 23) ligand clusters Cluster 1. 19 ligand types 38 ligands Cluster 2. 3 ligand types 14 ligands Cluster 3. 1 ligand type 13 ligands Cluster 4. 1 ligand type 13 ligands Cluster 5. 1 ligand type 6 ligands Cluster 6. 2 ligand types 2 ligands
Representative protein: 6sukA

Structures

PDB		Schematic diagram
6sukA
6gidA
2qpjA
1qvdA
1dmtA
		more ...

Cluster 1 contains 19 ligand types

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Ligand		Description
		1. Ligand: GOL × 2 glycerin Glycerol PDB codes: 1dmt(A), 4cth(A).
_Zn		2. Metal: _ZN × 15 PDB codes: 1dl9(A), 1dmt(A), 1r1h(A), 1r1i(A), 1r1j(A), 1y8j(A), 2qpj(A), 2yb9(A), 4cth(A), 5jmy(A), 6gid(A), 6suk(A), 6svy(A), 6thp(A), 6xvp(A).
		3. Ligand: EDO × 4 1,2-Ethanediol PDB codes: 6gid(A), 6suk(A),
		4. Ligand: RDF × 2 N-Alpha-L-Rhamnopyranosyloxy(hydroxyphosphinyl)-L- Leucyl-L-Tryptophan PDB codes: 1dmt(A), 4cth(A).
		5. Ligand: 6LD × 1 Sacubitrilat PDB code: 5jmy(A).
		6. Ligand: BIR × 1 N-[3-[(1-Aminoethyl)(hydroxy)phosphoryl]-2-(1,1'- Biphenyl-4-Ylmethyl)propanoyl]alanine PDB code: 1r1h(A).
		7. Ligand: D0W × 1 Sampatrilat-Asp PDB code: 6svy(A).
		8. Ligand: D0Z × 1 Sampatrilat PDB code: 6xvp(A).
		9. Ligand: FT8 × 1 Omapatrilat PDB code: 6suk(A).
		10. Ligand: HA0 × 1 Heteroarylalanine 5-Phenyl oxazole PDB code: 2yb9(A).
		11. Ligand: I20 × 1 (2s)-2-({(2s)-3-[(R)-[(1r)-1-({(4s)-4-Amino-5-[(2s)-2- Cyanopyrrolidin-1-Yl]-5- Oxopentanoyl}amino) ethyl](hydroxy)phosphoryl]-2-Benzylpropanoyl}amino) propanoic acid PDB code: 2qpj(A).
		12. Ligand: LEU-ALA-THR-ALA-CYS-PHE-GLY × 1 PDB code: 1qvd(A).
		13. Ligand: N9Q × 1 4-[[(2~{r})-1-[4-(3-Chlorophenyl)phenyl]-4-Oxidanyl-4- Oxidanylidene-Butan-2-Yl]amino]-4- Oxidanylidene- Butanoic acid PDB code: 6thp(A).
		14. Ligand: OIR × 1 N-(3-Phenyl-2-Sulfanylpropanoyl)phenylalanylalanine PDB code: 1r1j(A).
		15. Ligand: PEG × 1 Di(hydroxyethyl)ether PDB code: 6gid(A).
		16. Ligand: PO4 × 1 Phosphate ion PDB code: 6gid(A).
		17. Ligand: STS × 1 2-[(1s)-1-Benzyl-2-Sulfanylethyl]-1h-Imidazo[4,5- C]pyridin-5-Ium PDB code: 1y8j(A).
		18. Ligand: TI1 × 1 [2(r,S)-2-Sulfanylheptanoyl]-Phe-Ala PDB code: 1r1i(A).
		19. Ligand: TIO × 1 (2-Mercaptomethyl-3-Phenyl-Propionyl)-Glycine PDB code: 1dl9(A).

Cluster 2 contains 3 ligand types

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Ligand		Description
		1. Ligand: NAG × 12 n-acetylglucosamine N-Acetyl-D-Glucosamine PDB codes: 1dmt(A), 1r1h(A), 1r1i(A), 1r1j(A), 1y8j(A), 2qpj(A), 4cth(A), 6gid(A), 6suk(A), 6svy(A), 6thp(A), 6xvp(A).
		2. Ligand: GOL × 1 glycerin Glycerol PDB code: 4cth(A).
		3. Ligand: NAG-NAG × 1 NAG=N-Acetyl-D-Glucosamine. PDB code: 5jmy(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: NAG × 13 n-acetylglucosamine N-Acetyl-D-Glucosamine PDB codes: 1dmt(A), 1r1h(A), 1r1i(A), 1r1j(A), 1y8j(A), 2qpj(A), 4cth(A), 5jmy(A), 6gid(A), 6suk(A), 6svy(A), 6thp(A), 6xvp(A).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: NAG × 13 n-acetylglucosamine N-Acetyl-D-Glucosamine PDB codes: 1dmt(A), 1r1h(A), 1r1i(A), 1r1j(A), 1y8j(A), 2qpj(A), 4cth(A), 5jmy(A), 6gid(A), 6suk(A), 6svy(A), 6thp(A), 6xvp(A).

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: NAG × 6 n-acetylglucosamine N-Acetyl-D-Glucosamine PDB codes: 5jmy(A), 6gid(A), 6suk(A), 6svy(A), 6thp(A), 6xvp(A).

Cluster 6 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 4cth(A).
		2. Ligand: PEG × 1 Di(hydroxyethyl)ether PDB code: 6gid(A).