Ligand clusters for UniProt code O35904

Ligand clusters for O35904: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform from Mus musculus

		3 ligand clusters Cluster 1. 57 ligand types 60 ligands Cluster 2. 1 ligand type 1 ligand Cluster 3. 1 ligand type 1 ligand
Representative protein: 6zadA

Structures

PDB		Schematic diagram
6zadA
5t2lA
2wxgA
2wxkA
6ftnA
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Cluster 1 contains 57 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: 40L × 1 idelalisib 5-Fluoro-3-Phenyl-2-[(1s)-1-(7h-Purin-6-Ylamino) propyl]quinazolin-4(3h)-One PDB code: 4xe0(A).
		2. Ligand: GOL × 1 glycerin Glycerol PDB code: 2wxi(A).
		3. Ligand: EDO × 4 1,2-Ethanediol PDB codes: 5ncy(A), 5ncz(A),
		4. Ligand: 039 × 1 2-((9h-Purin-6-Ylthio)methyl)-5-Chloro-3-(2- Methoxyphenyl)quinazolin-4(3h)-One PDB code: 2wxf(A).
		5. Ligand: 67T × 1 2,4-Diamino-6-{[(1s)-1-(5-Chloro-4-Oxo-3-Phenyl-3,4- Dihydroquinazolin-2-Yl)ethyl]amino}pyrimidine- 5- Carbonitrile PDB code: 5i4u(A).
		6. Ligand: 68R × 1 2-[(1s)-1-({6-Amino-5-[(1h-Pyrazol-4-Yl) ethynyl]pyrimidin-4-Yl}amino)ethyl]-5-Chloro-3- Phenylquinazolin-4(3h)-One PDB code: 5i6u(A).
		7. Ligand: 6CY × 1 5-{4-[3-(4-Acetylpiperazine-1-Carbonyl) phenyl]quinazolin-6-Yl}-2-Methoxypyridine-3- Carbonitrile PDB code: 5is5(A).
		8. Ligand: 6PF × 1 N-[6-(5-Methanesulfonamido-6-Methoxypyridin-3-Yl)-1,3- Dihydro-2-Benzofuran-4-Yl]-2-(Morpholin-4- Yl)acetamide PDB code: 5l72(A).
		9. Ligand: 74F × 1 3-(Benzotriazol-1-Yl)-5-[1-Methyl-5-[(1~{s})-1- Morpholin-4-Ylethyl]-1,2,4-Triazol-3-Yl]pyrazin-2- Amine PDB code: 5t27(A).
		10. Ligand: 74H × 1 1-[3-Azanyl-6-[1-Methyl-5-(1-Phenylcyclopropyl)-1,2,4- Triazol-3-Yl]pyrazin-2-Yl]pyrazole-3- Carboxamide PDB code: 5t2l(A).
		11. Ligand: 74J × 1 1-[3-Azanyl-6-[1-Methyl-5-(1-Phenylcyclopropyl)-1,2,4- Triazol-3-Yl]pyrazin-2-Yl]pyrazole-4- Carboxamide PDB code: 5t2i(A).
		12. Ligand: 74K × 1 4-[3-Azanyl-6-[1-Methyl-5-(1-Phenylcyclopropyl)-1,2,4- Triazol-3-Yl]pyrazin-2-Yl]pyrazole-1- Carboxamide PDB code: 5t2g(A).
		13. Ligand: 74L × 1 4-[3-Azanyl-6-[1-Methyl-5-(1-Phenylcyclopropyl)-1,2,4- Triazol-3-Yl]pyrazin-2-Yl]-~{N},~{N}- Dimethyl- Pyrazole-1-Sulfonamide PDB code: 5t2d(A).
		14. Ligand: 74N × 1 4-[3-Azanyl-6-[1-Methyl-5-(1-Phenylcyclopropyl)-1,2,4- Triazol-3-Yl]pyrazin-2-Yl]benzamide PDB code: 5t2m(A).
		15. Ligand: 74O × 1 5-[1-Methyl-5-(1-Phenylcyclopropyl)-1,2,4-Triazol-3- Yl]-3-(1~{h}-Pyrazol-4-Yl)pyrazin-2-Amine PDB code: 5t2b(A).
		16. Ligand: 74Q × 1 3-(Benzotriazol-1-Yl)-5-[1-Methyl-5-(1- Phenylcyclopropyl)-1,2,4-Triazol-3-Yl]pyrazin-2-Amine PDB code: 5t28(A).
		17. Ligand: 76C × 1 2,4-Bis(azanyl)-6-[[(1~{s})-1-[5-Chloranyl-3-(5- Fluoranyl-4-Methyl-Pyridin-3-Yl)-4-Oxidanylidene- Quinazolin-2-Yl]ethyl]amino]pyrimidine-5-Carbonitrile PDB code: 5t7f(A).
		18. Ligand: 77C × 1 2,4-Diamino-6-{[(S)-[5-Chloro-8-Fluoro-4-Oxo-3- (Pyridin-3-Yl)-3,4-Dihydroquinazolin-2- Yl](cyclopropyl)methyl]amino}pyrimidine-5-Carbonitrile PDB code: 5t8i(A).
		19. Ligand: 8TK × 1 4-Azanyl-6-[[(1~{s})-1-(3-Methyl-5-Oxidanylidene-6- Phenyl-[1,3]thiazolo[3,2-A]pyridin-7- Yl) ethyl]amino]pyrimidine-5-Carbonitrile PDB code: 5ncy(A).
		20. Ligand: 8TN × 1 4-Azanyl-6-[[(1~{s})-1-[6-[3-[(Dimethylamino) methyl]phenyl]-3-Methyl-5-Oxidanylidene- [1, 3]thiazolo[3,2-A]pyridin-7-Yl]ethyl]amino]pyrimidine- 5-Carbonitrile PDB code: 5ncz(A).
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Cluster 2 contains 1 ligand type

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Ligand		Description
		1. Ligand: EDO × 1 1,2-Ethanediol PDB code: 5ncz(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: EDO × 1 1,2-Ethanediol PDB code: 5ncz(A).