PDBsum entry 6z4z

Transferase

PDB id: 6z4z

Contents

Protein chains

337 a.a.

Ligands

PO4 ×4

GOL

PQ5 ×3

Waters ×418

PDB id:

6z4z

Name:

Transferase

Title:

Crystal structure of clk1 in complex with macrocycle ods2004070

Structure:

Dual specificity protein kinase clk1. Chain: a, b, c. Synonym: cdc-like kinase 1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: clk1, clk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: -r3-prare2.

Resolution:

2.07Å R-factor: 0.177 R-free: 0.213

Authors:

A.Chaikuad,P.Benderitter,J.Hoflack,A.Denis,S.Knapp,Structural Genomics Consortium (Sgc)

Key ref:

A.Chaikuad et al. Crystal structure of clk1 in complex with macrocycle ods2004070. To be published, .

Date:

26-May-20 Release date: 03-Jun-20

Protein chains

P49759  (CLK1_HUMAN) -  Dual specificity protein kinase CLK1 from Homo sapiens

Seq: 484 a.a.

Struc: 337 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.12.1 - dual-specificity kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺
  3. L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site