PDBsum entry 6t54

Hydrolase

PDB id: 6t54

Contents

Protein chains

28 a.a.

250 a.a.

Ligands

ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYS-LEU

DMS ×2

GOL

NAG

MJK

Metals

_NA ×2

Waters ×226

PDB id:

6t54

Name:

Hydrolase

Title:

Thrombin in complex with a d-phe-pro-2-bromothiophene derivative

Structure:

Prothrombin. Chain: l. Synonym: coagulation factor ii. Prothrombin. Chain: h. Synonym: coagulation factor ii. Hirudin variant-2. Chain: i. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421

Resolution:

1.57Å R-factor: 0.139 R-free: 0.170

Authors:

K.Ngo,N.Abazi,A.Heine,G.Klebe

Key ref:

K.Ngo et al. Thrombin in complex with a d-Phe-Pro-2-Bromothiophene derivative. To be published, .

Date:

15-Oct-19 Release date: 18-Nov-20

Protein chain

P00734  (THRB_HUMAN) -  Prothrombin from Homo sapiens

Seq: 622 a.a.

Struc: 28 a.a.

Protein chain

P00734  (THRB_HUMAN) -  Prothrombin from Homo sapiens

Seq: 622 a.a.

Struc: 250 a.a.

Enzyme reactions

• Enzyme class: Chains L, H: E.C.3.4.21.5 - thrombin.
• Reaction: Preferential cleavage: Arg-|-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.