_EC 3.4.21.5 Thrombin. 386 PDB entries  
EC 3.-.-.- Hydrolases. [20,887 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,819 PDB entries]
EC 3.4.21.- Serine endopeptidases. [2,531 PDB entries]
EC 3.4.21.5 Thrombin. [386 PDB entries]    
1a0h

Reaction: Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and b.
Other name(s): Fibrinogenase.
Comments: More selective than trypsin and plasmin. Belongs to peptidase family S1. Formerly Ec 3.4.4.13.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 386 PDB entries in enzyme class E.C.3.4.21.5

  PDB code Protein
1a0h
The x-ray crystal structure of ppack-meizothrombin desf1: kringle/thrombin and carbohydrate/kringle/thrombin interact location of the linker chain
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: blood. Tissue: blood plasma. Tissue: blood plasma
Chains: A, B, D, E (159 residues) CATH domains: 2.40.20.10 4.10.140.10
1a2c
Structure of thrombin inhibited by aeruginosin298-a from a b alga
Source: Homo sapiens. Human. Organism_taxid: 9606. Microcystis aeruginosa. Organism_taxid: 1126
Chains: L, H (36 residues)
1a3b
Complex of human alpha-thrombin with the bifunctional borona inhibitor borolog1
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (27 residues)
1a3e
Complex of human alpha-thrombin with the bifunctional borona inhibitor borolog2
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (27 residues)
1a46
Thrombin complexed with hirugen and a beta-strand mimetic in
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (26 residues)
1a4w
Crystal structures of thrombin with thiazole-containing inhi probes of the s1' binding site
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood.
Chains: L, H (26 residues)
1a5g
Human thrombin complexed with novel synthetic peptide mimeti inhibitor and hirugen
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (27 residues)
1a61
Thrombin complexed with a beta-mimetic thiazole-containing i
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood.
Chains: L, H (27 residues)
1abi
Structure of the hirulog 3-thrombin complex and nature of th subsites of substrates and inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (33 residues)
1abj
Structure of the hirulog 3-thrombin complex and nature of th subsites of substrates and inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: plasma. Organ: plasma
Chains: L, H (27 residues)
1ad8
Complex of thrombin with and inhibitor containing a novel p1
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (28 residues)
1ae8
Human alpha-thrombin inhibition by eoc-d-phe-pro-azalys-onp
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (36 residues)
1afe
Human alpha-thrombin inhibition by cbz-pro-azalys-onp
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (36 residues)
1aht
Crystal structure of human alpha-thrombin complexed with hir p-amidinophenylpyruvate at 1.6 angstroms resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma.
Chains: L, H (28 residues)
1ai8
Human alpha-thrombin ternary complex with the exosite inhibi hirugen and active site inhibitor phch2oco-d-dpa-pro-boromp
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (27 residues)
1aix
Human alpha-thrombin ternary complex with exosite inhibitor and active site inhibitor phch2oco-d-dpa-pro-boroval
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (27 residues)
1avg
Thrombin inhibitor from triatoma pallidipennis
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: blood. Tissue: blood. Secretion: blood. Other_details: bovine thrombin was purified from from fresh ox blood according to reported protocols. Triatoma pallidipennis.
Chains: L, H (41 residues) CATH domain: 4.10.140.10
1awf
Novel covalent thrombin inhibitor from plant extract
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (27 residues)
1awh
Novel covalent thrombin inhibitor from plant extract
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood plasma. Tissue: blood plasma
Chains: A, B, C, D (36 residues)
1ay6
Thrombin inhibitor from theonalla, cyclotheanamide-based mac tripeptide motif
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421. Other_details: acetyl hirugen
Chains: L, H (29 residues)
1b5g
Human thrombin complexed with novel synthetic peptide mimeti inhibitor and hirugen
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (29 residues)
1b7x
Structure of human alpha-thrombin y225i mutant bound to d- phe-pro-arg-chloromethylketone
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932. Expression_system_cell_line: baby hamster kidney cells (bhk-21).
Chains: A, B (26 residues)
1ba8
Thrombin inhibitor with a rigid tripeptidyl aldehydes
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (30 residues)
1bb0
Thrombin inhibitors with rigid tripeptidyl aldehydes
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (26 residues)
1bbr
The structure of residues 7-16 of the a alpha chain of human fibrinogen bound to bovine thrombin at 2.3 angstroms resolution
Source: Bos taurus. Cattle. Organism_taxid: 9913. Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9913
Chains: L, H, E, J, K, M, N (36 residues) CATH domain: 4.10.140.10
1bcu
Alpha-thrombin complexed with hirugen and proflavin
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (26 residues)
1bhx
X-ray structure of the complex of human alpha thrombin with inhibitor sdz 229-357
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B, F (30 residues)
1bmm
Human alpha-thrombin complexed with [s-(r ,R )]-4-[(Aminoimi amino]-n-[[1-[3-hydroxy-2-[(2-naphthalenylsulfonyl)amino]-1 oxopropyl]-2-pyrrolidinyl] methyl]butanamide (bms-186282)
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Tissue: plasma
Chains: L, H (28 residues)
1bmn
Human alpha-thrombin complexed with [s-(r ,R )]-1-(Aminoimin n-[[1-[n-[(2-naphthalenylsulfonyl)-l-seryl]-pyrrolidinyl]me piperidenecarboxamide (bms-189090)
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Tissue: plasma
Chains: L, H (26 residues)
1bth
Structure of thrombin complexed with bovine pancreatic trypsin inhibitor
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: lung. Expressed in: mesocricetus auratus. Expression_system_taxid: 10036. Expression_system_cell_line: bhk-21. Organ: lung
Chains: L, H, J, K (31 residues)
1c1u
Recruiting zinc to mediate potent, specific inhibition of se proteases
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: L, H (36 residues)
1c1v
Recruiting zinc to mediate potent, specific inhibition of se proteases
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes
Chains: L, H (36 residues)
1c1w
Recruiting zinc to mediate potent, specific inhibition of se proteases
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes
Chains: L, H (36 residues)
1c4u
Selective non electrophilic thrombin inhibitors with cyclohe moieties.
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Synthetic: yes. Other_details: chemically synthesized
Chains: 1, 2 (30 residues)
1c4v
Selective non electrophilic thrombin inhibitors with cyclohe moieties.
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Synthetic: yes
Chains: 1, 2 (36 residues)
1c4y
Selective non-electrophilic thrombin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Synthetic: yes
Chains: 1, 2 (27 residues)
1c5l
Structural basis for selectivity of a small molecule, s1-bin micromolar inhibitor of urokinase type plasminogen activato
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: L, H (36 residues)
1c5n
Structural basis for selectivity of a small molecule, s1-bin micromolar inhibitor of urokinase type plasminogen activato
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes
Chains: L, H (36 residues)
1c5o
Structural basis for selectivity of a small molecule, s1-bin micromolar inhibitor of urokinase type plasminogen activato
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes
Chains: L, H (36 residues)
1ca8
Thrombin inhibitors with rigid tripeptidyl aldehydes
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (26 residues)
1d3d
Crystal structure of human alpha thrombin in complex with benzothiophene inhibitor 4
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (28 residues)
1d3p
Crystal structure of human aplha-thrombin in complex with benzo[b]thiophene inhibitor 3
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (28 residues)
1d3q
Crystal structure of human alpha thrombin in complex with benzo[b]thiophene inhibitor 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (28 residues)
1d3t
Crystal structure of human alpha thrombin in complex with benzo[b]thiophene inhibitor 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (28 residues)
1d4p
Crystal structure of human alpha thrombin in complex with 5- amidinoindole-4-benzylpiperidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (28 residues)
1d6w
Structure of thrombin complexed with selective non-electroph inhibitors having cyclohexyl moieties at p1
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421. Other_details: this sequence was chemically synthesized
Chain: A (278 residues) CATH domains: 2.40.10.10 2.40.10.10
1d9i
Structure of thrombin complexed with selective non-electophi inhibitors having cyclohexyl moieties at p1
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421. Other_details: this sequence was chemically synthesized
Chain: A (279 residues) CATH domains: 2.40.10.10 2.40.10.10
1de7
Interaction of factor xiii activation peptide with alpha-thr crystal structure of the enzyme-substrate complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Synthetic: yes
Chains: L, H, J, K (28 residues)
1dit
Complex of a divalent inhibitor with thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606.
Chains: L, H (29 residues)
1dm4
Ser195ala mutant of human thrombin complexed with fibrinopep 16)
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes
Chains: A, B (33 residues)
1doj
Crystal structure of human alpha-thrombin Rwj-51438 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Cellular_location: plasma. Synthetic: yes. Other_details: hirugen, comes from hirudin
Chain: A (293 residues) CATH domains: 2.40.10.10 2.40.10.10
1dwb
Crystallographic analysis at 3.0-angstroms resolution of the to human thrombin of four active site-directed inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: plasma. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (29 residues)
1dwc
Crystallographic analysis at 3.0-angstroms resolution of the to human thrombin of four active site-directed inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (29 residues)
1dwd
Crystallographic analysis at 3.0-angstroms resolution of the to human thrombin of four active site-directed inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (29 residues)
1dwe
Crystallographic analysis at 3.0-angstroms resolution of the to human thrombin of four active site-directed inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (28 residues)
1dx5
Crystal structure of the thrombin-thrombomodulin complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Secretion: blood plasma. Other_details: purified from frozen plasma. Synthetic: yes. Tissue: endothelium. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
Chains: A, B, C, D, M, N, O, P (36 residues)
1e0f
Crystal structure of the human alpha-thrombin-haemadin complex: an exosite ii-binding inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Other_details: human thrombin was purified from human serum according to reported protocols. Haemadipsa sylvestris. Organism_taxid: 13555. Expressed in: escherichia coli.
Chains: A, B, C, D, E, F (36 residues)
1eb1
Complex structure of human thrombin with n-methyl-arginine i
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Synthetic: yes
Chains: H, L (257 residues) CATH domains: 2.40.10.10 2.40.10.10
1eoj
Design of p1' and p3' residues of trivalent thrombin inhibit their crystal structures
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Other_details: this sequence was chemically synthesized
Chain: A (278 residues) CATH domains: 2.40.10.10 2.40.10.10
1eol
Design of p1' and p3' residues of trivalent thrombin inhibit their crystal structures
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Other_details: this sequence was chemically synthesized
Chain: A (278 residues) CATH domains: 2.40.10.10 2.40.10.10
1etr
Refined 2.3 angstroms x-ray crystal structure of bovine thro complexes formed with the benzamidine and arginine-based th inhibitors napap, 4-tapap and mqpa: a starting point for im antithrombotics
Source: Bos taurus. Cow. Organism_taxid: 9913. Organism_taxid: 9913
Chains: L, H (36 residues) CATH domain: 4.10.140.10
1ets
Refined 2.3 angstroms x-ray crystal structure of bovine thro complexes formed with the benzamidine and arginine-based th inhibitors napap, 4-tapap and mqpa: a starting point for im antithrombotics
Source: Bos taurus. Cow. Organism_taxid: 9913. Organism_taxid: 9913
Chains: L, H (36 residues) CATH domain: 4.10.140.10
1ett
Refined 2.3 angstroms x-ray crystal structure of bovine thro complexes formed with the benzamidine and arginine-based th inhibitors napap, 4-tapap and mqpa: a starting point for im antithrombotics
Source: Bos taurus. Cow. Organism_taxid: 9913. Organism_taxid: 9913
Chains: L, H (36 residues) CATH domain: 4.10.140.10
1fpc
Active site mimetic inhibition of thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (26 residues)
1fph
The interaction of thrombin with fibrinogen: a structural ba its specificity
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Synthetic: yes
Chains: L, H (36 residues)
1g30
Thrombin inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: blood serum. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (27 residues)
1g32
Thrombin inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: blood serum. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (27 residues)
1g37
Crystal structure of human alpha-thrombin complexed with bch exosite-directed peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Other_details: thrombin purchased from haematologic technol synthetic: yes
Chain: A (277 residues) CATH domains: 2.40.10.10 2.40.10.10
1ghv
A novel serine protease inhibition motif involving a multi-c short hydrogen bonding network at the active site
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: L, H (36 residues)
1ghw
A novel serine protease inhibition motif involving a multi-c short hydrogen bonding network at the active site
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: L, H (36 residues)
1ghx
A novel serine protease inhibition motif involving a multi-c short hydrogen bonding network at the active site
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: L, H (36 residues)
1ghy
A novel serine protease inhibition motif involving a multi-c short hydrogen bonding network at the active site
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: L, H (36 residues)
1gj4
Selectivity at s1, h2o displacement, upa, tpa, ser190/ala190 structure-based drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: L, H (28 residues)
1gj5
Selectivity at s1, h2o displacement, upa, tpa, ser190/ala190 structure-based drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: L, H (36 residues)
1h8d
X-ray structure of the human alpha-thrombin complex with a t phosphonate inhibitor.
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Organism_taxid: 9606
Chains: H, L (260 residues) CATH domains: 2.40.10.10 2.40.10.10
1h8i
X-ray crystal structure of human alpha-thrombin with a tripe phosphonate inhibitor.
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Organism_taxid: 9606
Chains: H, L (253 residues) CATH domains: 2.40.10.10 2.40.10.10
1hag
The isomorphous structures of prethrombin2, hirugen-and ppac thrombin: changes accompanying activation and exosite bindi thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chain: E (295 residues) CATH domains: 2.40.10.10 2.40.10.10
1hah
The isomorphous structures of prethrombin2, hirugen-and ppac thrombin: changes accompanying activation and exosite bindi thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (36 residues)
1hai
The isomorphous structures of prethrombin2, hirugen-and ppac thrombin: changes accompanying activation and exosite bindi thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: plasma. Organ: plasma
Chains: L, H (36 residues)
1hao
Complex of human alpha-thrombin with a 15mer oligonucleotide ggttggtgtggttgg (based on nmr model of DNA)
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: L, H (27 residues)
1hap
Complex of human alpha-thrombin with a 15mer oligonucleotide ggttggtgtggttgg (based on x-ray model of DNA)
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: L, H (27 residues)
1hbt
Human alpha-thrombin complexed with a peptidyl pyridinium me ketone containing bivalent inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dkfzp470k2111, f2. Gene: f2. Synthetic: yes
Chains: L, H (27 residues)
1hdt
Structure of a retro-binding peptide inhibitor complexed wit alpha-thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (33 residues)
1hgt
Structure of the hirugen and hirulog 1 complexes of alpha- thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (36 residues)
1hlt
The structure of a nonadecapeptide of the fifth egf domain o thrombomodulin complexed with thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606.
Chains: L, H, J, K (27 residues)
1hrt
The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8 angstroms resolution
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: unidentified. Expression_system_taxid: 32644. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Expression_system_taxid: 32644
Chains: L, H (36 residues) CATH domain: 4.10.140.10
1hut
The structure of alpha-thrombin inhibited by a 15-mer single DNA aptamer
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Secretion: plasma. Secretion: plasma
Chains: L, H (36 residues)
1hxe
Serine protease
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood.
Chains: L, H (26 residues)
1hxf
Human thrombin complex with hirudin variant
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (26 residues)
1id5
Crystal structure of bovine thrombin complex with protease i ecotin
Source: Bos taurus. Cattle. Organism_taxid: 9913. Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: L, H (30 residues) CATH domain: 4.10.140.10
1ihs
Crystal structure of the complex of human alpha-thrombin and hydrolyzable bifunctional inhibitors, hirutonin-2 and hirut
Source: Homo sapiens. Human. Organism_taxid: 9606.
Chains: L, H (30 residues)
1iht
Crystal structure of the complex of human alpha-thrombin and hydrolyzable bifunctional inhibitors, hirutonin-2 and hirut
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes
Chains: L, H (30 residues)
1jmo
Crystal structure of the heparin cofactor ii-s195a thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: bhk culture. Expression_system_organ: kidney. Other_details: plasma purified human heparin cofactor ii
Chains: L, H (47 residues) CATH domain: 4.10.140.10
1jou
Crystal structure of native s195a thrombin with an unoccupie site
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: bhk culture. Expression_system_organ: kidney. Expression_system_organ: kidney
Chains: A, B, C, D, E, F (45 residues) CATH domain: 4.10.140.10
1jwt
Crystal structure of thrombin in complex with a novel bicyclic lactam inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (299 residues) CATH domains: 2.40.10.10 2.40.10.10
1k21
Human thrombin-inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (27 residues)
1k22
Human thrombin-inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (29 residues)
1kts
Thrombin inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (27 residues)
1ktt
Thrombin inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (27 residues)
1lhc
Human alpha-thrombin complexed with ac-(d)phe-pro-boroarg-oh
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (26 residues)
1lhd
Human alpha-thrombin complexed with ac-(d)phe-pro-borolys-oh
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (26 residues)
1lhe
Human alpha-thrombin complexed with ac-(d)phe-pro-boro-n- butyl-amidino-glycine-oh
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (26 residues)
1lhf
Human alpha-thrombin complexed with ac-(d)phe-pro-boro- homolys-oh
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (26 residues)
1lhg
Human alpha-thrombin complexed with ac-(d)phe-pro- boroornithine-oh
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (26 residues)
1mh0
Crystal structure of the anticoagulant slow form of thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_organ: kidney. Expression_system_tissue: kidney cells.
Chains: A, B (277 residues) CATH domains: 2.40.10.10 2.40.10.10
1mkw
The co-crystal structure of unliganded bovine alpha- thrombin and prethrombin-2: movement of the yppw segment and active site residues upon ligand binding
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: L, H, K (29 residues) CATH domain: 4.10.140.10
1mkx
The co-crystal structure of unliganded bovine alpha- thrombin and prethrombin-2: movement of the yppw segment and active site residues upon ligand binding
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: L, H, K (29 residues) CATH domain: 4.10.140.10
1mu6
Crystal structure of thrombin in complex with l-378,622
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421. Other_details: this peptide was chemically synthesized. It naturally found in hirudo medicinalis (medicinal leech).
Chains: A, B (26 residues)
1mu8
Thrombin-hirugen_l-378,650
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Synthetic: yes. Other_details: this peptide was chemically synthesized. It naturally found in hirudo medicinalis (medicinal leech).
Chains: A, B (26 residues)
1mue
Thrombin-hirugen-l405,426
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421. Other_details: this peptide was chemically synthesized. It naturally found in hirudo medicinalis (medicinal leech).
Chains: A, B (26 residues)
1nl1
Bovine prothrombin fragment 1 in complex with calcium ion
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (147 residues) CATH domain: 2.40.20.10
1nl2
Bovine prothrombin fragment 1 in complex with calcium and lysophosphotidylserine
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (146 residues) CATH domain: 2.40.20.10
1nm6
Thrombin in complex with selective macrocyclic inhibitor at
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: plasma from blood. Synthetic: yes
Chain: A (276 residues) CATH domains: 2.40.10.10 2.40.10.10
1no9
Design of weakly basic thrombin inhibitors incorporating nov binding functions: molecular and x-ray crystallographic stu
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: plasma. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: L, H (36 residues)
1nrn
Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: L, H (29 residues)
1nro
Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: L, H (29 residues)
1nrp
Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: L, H (29 residues)
1nrq
Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes
Source: Homo sapiens. Human. Organism_taxid: 9606.
Chains: L, H (23 residues)
1nrr
Crystallographic structures of thrombin complexed with throm receptor peptides: existence of expected and novel binding
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: L, H (26 residues)
1nrs
Crystallographic structures of thrombin complexed with throm receptor peptides: existence of expected and novel binding
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (27 residues)
1nt1
Thrombin in complex with selective macrocyclic inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: plasma from blood. Synthetic: yes
Chain: A (276 residues) CATH domains: 2.40.10.10 2.40.10.10
1nu7
Staphylocoagulase-thrombin complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Staphylococcus aureus. Organism_taxid: 1280. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, E, F (28 residues)
1nu9
Staphylocoagulase-prethrombin-2 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Staphylococcus aureus. Organism_taxid: 1280. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, D (290 residues) CATH domains: 2.40.10.10 2.40.10.10
1ny2
Human alpha thrombin inhibited by rppgf and hirugen
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: alpha thrombin catalytic domain. Synthetic: yes. Other_details: chemically synthesized. Other_details: chemically synthesized
Chains: 1, 2 (36 residues)
1nzq
D-phe-pro-arg-type thrombin inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Gene: f2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: L, H (28 residues)
1o0d
Human thrombin complexed with a d-phe-pro-arg-type inhibitor terminal hirudin derived exo-site inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Gene: f2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: L, H (34 residues)
1o2g
Elaborate manifold of short hydrogen bond arrays mediating b active site-directed serine protease inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: L, H (36 residues)
1o5g
Dissecting and designing inhibitor selectivity determinants site using an artificial ala190 protease (ala190 upa)
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: L, H (33 residues)
1ook
Crystal structure of the complex of platelet receptor gpib-a human alpha-thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purified from plasma. Synthetic: yes. Other_details: chemically synthesized. Gene: gp1ba. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (36 residues)
1oyt
Complex of recombinant human thrombin with a designed fluori inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: ovary. Synthetic: yes. Other_details: the sequence was chemically synthesized. The
Chains: L, H (27 residues)
1p8v
Crystal structure of the complex of platelet receptor gpib-a alpha-thrombin at 2.6a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gp1ba. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_organ: ovary cells. Other_details: isolated from human plasma. Other_details: isolated from human plasma
Chains: B, C (29 residues)
1ppb
The refined 1.9 angstroms crystal structure of human alpha-t interaction with d-phe-pro-arg chloromethylketone and signi the tyr-pro-pro-trp insertion segment
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: plasma. Organ: plasma
Chains: L, H (36 residues)
1qbv
Crystal structure of thrombin complexed with an guanidine-mi inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: homo sapiens. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (26 residues)
1qhr
Novel covalent active site thrombin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421. Other_details: this peptide was chemically synthesized. The for this peptide occurs naturally in medicinal leech (hirud
Chains: A, B (36 residues)
1qj1
Novel covalent active site thrombin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (36 residues)
1qj6
Novel covalent active site thrombin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (36 residues)
1qj7
Novel covalent active site thrombin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (36 residues)
1qur
Human alpha-thrombin in complex with bivalent, benzamidine-b synthetic inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Other_details: the inhibitor was chemically synthesized as combination of organic and solid phase peptide synthesis. T site binding portion is derived from the synthetical inhibi napap,the sequence of the exosite binding portion was deriv the naturally occuring inhibitor hirudin, isolated from the
Chains: L, H (27 residues)
1qvh
Crystal structure of the complex between thrombin and the central "e" region of fibrin
Source: Homo sapiens. Human. Synthetic: yes. Other_details: the inhibitor was chemically synthesized.. Other_details: proteolytic fragment. Other_details: proteolytic fragment
Chains: A, B, D, E (32 residues)
1rd3
2.5a structure of anticoagulant thrombin variant e217k
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetinae gen. Sp.. Expression_system_taxid: 36483.
Chains: A, B, C, D (33 residues)
1riw
Thrombin in complex with natural product inhibitor oscillari
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: plasma. Synthetic: yes. Other_details: the chemical synthesis
Chains: A, B, C (27 residues)
1sb1
Novel non-covalent thrombin inhibitors incorporating p1 4,5, tetrahydrobenzothiazole arginine side chain mimetics
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Synthetic: yes
Chains: L, H (29 residues)
1sfq
Fast form of thrombin mutant r(77a)a bound to ppack
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
Chains: A, B, D, E (29 residues)
1sg8
Crystal structure of the procoagulant fast form of thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
Chains: A, B, D, E (27 residues)
1sgi
Crystal structure of the anticoagulant slow form of thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
Chains: A, B, D, E (32 residues)
1shh
Slow form of thrombin bound with ppack
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
Chains: A, B, D, E (29 residues)
1sl3
Crystal structue of thrombin in complex with a potent p1 het aryl based inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: pancreas. Synthetic: yes
Chain: A (276 residues) CATH domains: 2.40.10.10 2.40.10.10
1sr5
Antithrombin-anhydrothrombin-heparin ternary complex structu
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Tissue: plasma
Chains: B, C (32 residues)
1t4u
Crystal structure analysis of a novel oxyguanidine bound to
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (26 residues)
1t4v
Crystal structure analysis of a novel oxyguanidine bound to
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (26 residues)
1ta2
Crystal structure of thrombin in complex with compound 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: pancreas. Synthetic: yes
Chain: A (276 residues) CATH domains: 2.40.10.10 2.40.10.10
1ta6
Crystal structure of thrombin in complex with compound 14b
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: pancreas. Synthetic: yes
Chain: A (276 residues) CATH domains: 2.40.10.10 2.40.10.10
1tb6
2.5a crystal structure of the antithrombin-thrombin-heparin complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: serpinc1, at3. Expression_system_taxid: 10029
Chains: L, H (43 residues) CATH domain: 4.10.140.10
1tbq
Crystal structure of insect derived double domain kazal inhibitor rhodniin in complex with thrombin
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: plasma. Rhodnius prolixus. Organism_taxid: 13249. Gene: prpti. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: L, H, J, K (49 residues) CATH domain: 4.10.140.10
1tbr
Crystal structure of insect derived double domain kazal inhi rhodniin in complex with thrombin
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: plasma. Rhodnius prolixus. Organism_taxid: 13249. Gene: prpti. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: L, H, J, K (49 residues) CATH domain: 4.10.140.10
1tbz
Human thrombin with active site n-methyl-d phenylalanyl-n-[5 (aminoiminomethyl)amino]-1-{{benzothiazolyl)carbonyl] butyl prolinamide trifluroacetate and exosite-hirugen
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (25 residues)
1thp
Structure of human alpha-thrombin y225p mutant bound to d-ph chloromethylketone
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932. Expression_system_cell_line: baby hamster kidney cells (bhk
Chains: A, B (27 residues)
1thr
Structures of thrombin complexes with a designed and a natural exosite inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood. Hirudinaria manillensis. Organism_taxid: 6419
Chains: L, H (27 residues)
1ths
Structures of thrombin complexes with a designed and a natur inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood. Synthetic: yes
Chains: L, H (33 residues)
1tmb
Molecular basis for the inhibition of human alpha-thrombin b macrocyclic peptide cyclotheonamide a
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Theonella sp.. Sponges. Organism_taxid: 73791
Chains: L, H (29 residues)
1tmt
Changes in interactions in complexes of hirudin derivatives alpha-thrombin due to different crystal forms
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli.
Chains: L, H (27 residues)
1tmu
Changes in interactions in complexes of hirudin derivatives alpha-thrombin due to different crystal forms
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (28 residues)
1toc
Structure of serine proteinase
Source: Bos taurus. Cattle. Organism_taxid: 9913. Tissue: plasma. Expressed in: escherichia coli. Expression_system_taxid: 562. Ornithodoros moubata. Organism_taxid: 6938.
Chains: A, B, C, D, E, F, G, H (28 residues) CATH domain: 4.10.140.10
1tom
Alpha-thrombin complexed with hirugen
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (26 residues)
1tq0
Crystal structure of the potent anticoagulant thrombin mutan w215a/e217a in free form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: kidney.
Chains: A, B, C, D (31 residues)
1tq7
Crystal structure of the anticoagulant thrombin mutant w215a bound to ppack
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: kidney.
Chains: A, B (44 residues) CATH domain: 4.10.140.10
1twx
Crystal structure of the thrombin mutant d221a/d222k
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: kidney. Synthetic: yes
Chains: A, B (28 residues)
1ucy
Thrombin complexed with fibrinopeptide a alpha (residues 7- 19). Three complexes, one with epsilon-thrombin and two with alpha-thrombin
Source: Bos taurus. Cattle. Organism_taxid: 9913. Tissue: blood. Tissue: blood
Chains: L, H, E, J, K, M, N (36 residues) CATH domain: 4.10.140.10
1uma
Alpha-thrombin (hirugen) complexed with na-(n,n-dimethylcarb alpha-azalysine
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Tissue: plasma
Chains: L, H (36 residues)
1uvs
Bovine thrombin--bm51.1011 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood. Tissue: blood
Chains: L, H (27 residues)
1uvt
Bovine thrombin--bm14.1248 complex
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: blood. Tissue: blood. Tissue: blood
Chains: L, H (25 residues) CATH domain: 4.10.140.10
1uvu
Bovine thrombin--bm12.1700 complex
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: blood. Tissue: blood. Tissue: blood
Chains: L, H (24 residues) CATH domain: 4.10.140.10
1vit
Thrombin:hirudin 51-65 complex
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: blood. Tissue: blood. Tissue: blood
Chains: L, H, M, F, G (36 residues) CATH domain: 4.10.140.10
1vr1
Specifity for plasminogen activator inhibitor-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetinae gen. Sp.. Expression_system_taxid: 36483. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421.
Chains: L, H (27 residues)
1vzq
Complex of thrombin with designed inhibitor 7165
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: ovary. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421.
Chains: H, L (250 residues) CATH domains: 2.40.10.10 2.40.10.10
1w7g
Alpha-thrombin complex with sulfated hirudin (residues 54-65 arginine template inhibitor cs107
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: plasma. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Cell: plasma
Chains: H, L (253 residues) CATH domains: 2.40.10.10 2.40.10.10
1way
Active site thrombin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (29 residues)
1wbg
Active site thrombin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (32 residues)
1xm1
Nonbasic thrombin inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Other_details: chemically synthesized
Chain: A (284 residues) CATH domains: 2.40.10.10 2.40.10.10
1xmn
Crystal structure of thrombin bound to heparin
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B, C, D, E, F, G, H (31 residues)
1ycp
The crystal structure of fibrinogen-aa peptide 1-23 (f8y) bo bovine thrombin explains why the mutation of phe-8 to tyros strongly inhibits normal cleavage at arginine-16
Source: Bos taurus. Cattle. Organism_taxid: 9913. Tissue: blood. Tissue: blood
Chains: L, H, J, K, M (29 residues) CATH domain: 4.10.140.10
1ype
Thrombin inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421. Other_details: the peptide was chemically synthesized.
Chains: L, H (27 residues)
1ypg
Thrombin inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421. Other_details: the peptide was chemically synthesized.
Chains: L, H (27 residues)
1ypj
Thrombin inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: L, H (27 residues)
1ypk
Thrombin inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421. Other_details: this sequence occurs naturally
Chains: L, H (27 residues)
1ypl
X-ray crystal structure of thrombin inhibited by synthetic cyanopeptide analogue ra-1008
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421. Other_details: chemically synthesized
Chains: L, H (27 residues)
1ypm
X-ray crystal structure of thrombin inhibited by synthetic cyanopeptide analogue ra-1014
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421. Other_details: chemically synthesized
Chains: L, H (27 residues)
1z71
Thrombin and p2 pyridine n-oxide inhibitor complex structure
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Other_details: occurs naturally in medicinal leech hirudo medicinalis
Chain: A (276 residues) CATH domains: 2.40.10.10 2.40.10.10
1z8i
Crystal structure of the thrombin mutant g193a bound to ppac
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: mesocricetus auratus. Expression_system_taxid: 10036. Expression_system_organ: kidney cells.
Chains: A, B (39 residues)
1z8j
Crystal structure of the thrombin mutant g193p bound to ppac
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_organ: kidney. Expression_system_taxid: 10029
Chains: A, B (40 residues) CATH domain: 4.10.140.10
1zgi
Thrombin in complex with an oxazolopyridine inhibitor 21
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421. Other_details: this sequence corresponds to thE C-terminus hirudin.
Chain: A (276 residues) CATH domains: 2.40.10.10 2.40.10.10
1zgv
Thrombin in complex with an oxazolopyridine inhibitor 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421. Other_details: this sequence corresponds to thE C-terminus hirudin.
Chain: A (276 residues) CATH domains: 2.40.10.10 2.40.10.10
1zrb
Thrombin in complex with an azafluorenyl inhibitor 23b
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: pancreas. Synthetic: yes
Chain: A (276 residues) CATH domains: 2.40.10.10 2.40.10.10
2a0q
Structure of thrombin in 400 mm potassium chloride
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: kidney cells.
Chains: A, B, C, D (30 residues)
2a1d
Staphylocoagulase bound to bovine thrombin
Source: Bos taurus. Cattle. Organism_taxid: 9913. Staphylococcus aureus. Organism_taxid: 1280. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, E, F (41 residues) CATH domain: 4.10.140.10
2a2x
Orally active thrombin inhibitors in complex with thrombin i
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Other_details: synthetic peptide
Chains: L, H (34 residues)
2a45
Crystal structure of the complex between thrombin and the ce region of fibrin
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic fragment. Other_details: proteolytic fragment
Chains: A, B, D, E (32 residues)
2afq
1.9 angstrom crytal structure of wild-type human thrombin in sodium free state
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (29 residues)
2ank
Orally active thrombin inhibitors in complex with thrombin a exosite decapeptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Other_details: synthetic peptide
Chains: H, L (250 residues) CATH domains: 2.40.10.10 2.40.10.10
2anm
Ternary complex of an orally active thrombin inhibitor with human thrombin and a c-terminal hirudin derived exo-sit inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: H, L (250 residues) CATH domains: 2.40.10.10 2.40.10.10
2b5t
2.1 angstrom structure of a nonproductive complex between antithrombin, synthetic heparin mimetic sr123781 and two s1 thrombin molecules
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: mesocricetus auratus. Expression_system_taxid: 10036. Expression_system_cell_line: bhk cell line. Gene: serpinc1, at3. Expression_system_cell_line: bhk cell line
Chains: A, B, C, D (47 residues) CATH domain: 4.10.140.10
2bdy
Thrombin in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Other_details: this sequence occurs naturally in hirudo med (medicinal leech).
Chain: A (276 residues) CATH domains: 2.40.10.10 2.40.10.10
2bvr
Human thrombin complexed with fragment-based small molecules occupying the s1 pocket
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Expression_system_taxid: 562
Chains: H, L (251 residues) CATH domains: 2.40.10.10 2.40.10.10
2bvs
Human thrombin complexed with fragment-based small molecules occupying the s1 pocket
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Expression_system_taxid: 562
Chains: H, L (252 residues) CATH domains: 2.40.10.10 2.40.10.10
2bvx
Design and discovery of novel, potent thrombin inhibitors wi solubilizing cationic p1-p2-linker
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Expression_system_taxid: 562
Chains: H, L (253 residues) CATH domains: 2.40.10.10 2.40.10.10
2bxt
Design and discovery of novel, potent thrombin inhibitors wi solubilizing cationic p1-p2-linker
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Human. Expression_system_taxid: 562
Chains: H, L (253 residues) CATH domains: 2.40.10.10 2.40.10.10
2bxu
Design and discovery of novel, potent thrombin inhibitors wi solubilizing cationic p1-p2-linker
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Human. Expression_system_taxid: 562
Chains: H, L (253 residues) CATH domains: 2.40.10.10 2.40.10.10
2c8w
Thrombin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (29 residues)
2c8x
Thrombin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (29 residues)
2c8y
Thrombin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (29 residues)
2c8z
Thrombin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (29 residues)
2c90
Thrombin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (29 residues)
2c93
Thrombin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Hirudo medicinalis. Human nal leech. Organism_taxid: 6421
Chains: A, B (29 residues)
2cf8
Complex of recombinant human thrombin with a inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: ovary. Synthetic: yes. Hirudo medicinalis. Medicinal leech.
Chains: H, L (250 residues) CATH domains: 2.40.10.10 2.40.10.10
2cf9
Complex of recombinant human thrombin with a inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: ovary. Synthetic: yes. Hirudo medicinalis. Medicinal leech.
Chains: H, L (250 residues) CATH domains: 2.40.10.10 2.40.10.10
2cn0
Complex of recombinant human thrombin with a designed inhibi
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: ovary. Synthetic: yes. Hirudo medicinalis. Human nal leech.
Chains: H, L (250 residues) CATH domains: 2.40.10.10 2.40.10.10
2feq
Orally active thrombin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Other_details: deduced from c-terminus of hirudin
Chains: L, H (28 residues)
2fes
Orally active thrombin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Other_details: deduced from c-terminus of hirudin
Chains: L, H (31 residues)
2gde
Thrombin in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes
Chains: L, H (27 residues)
2gp9
Crystal structure of the slow form of thrombin in a self- inhibited conformation
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
Chains: A, B (32 residues)
2h9t
Crystal structure of human alpha-thrombin in complex with suramin
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: human plasma. Synthetic: yes
Chains: L, H (28 residues)
2hgt
Structure of the hirugen and hirulog 1 complexes of alpha-th
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Synthetic: yes
Chains: L, H (33 residues)
2hnt
Crystallographic structure of human gamma-thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: L, C, E, F (28 residues)
2hpp
Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human ppack-thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Bos taurus. Bovine. Organism_taxid: 9913
Chains: L, H, P (30 residues)
2hpq
Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human ppack-thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: L, H, P (30 residues)
2hwl
Crystal structure of thrombin in complex with fibrinogen gam peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_organ: kidney. Synthetic: yes. Other_details: the protein was chemically synthesized. The
Chains: A, B, C, D (27 residues)
2jh0
Human thrombin hirugen inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: C, D (28 residues)
2jh5
Human thrombin hirugen inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: C, D (28 residues)
2jh6
Human thrombin hirugen inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: C, D (28 residues)
2ocv
Structural basis of na+ activation mimicry in murine thrombi
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: f2, cf2. Expression_system_cell_line: hamster kidney cell. Expression_system_cell_line: hamster kidney cell
Chains: A, B (39 residues)
2od3
Human thrombin chimera with human residues 184a, 186, 186a, and 222 replaced by murine thrombin equivalents.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: kidney cell system. Expression_system_cell: kidney cell system
Chains: A, B (28 residues)
2ody
Thrombin-bound boophilin displays a functional and accessibl reactive-site loop
Source: Bos taurus. Cattle. Organism_taxid: 9913. Rhipicephalus microplus. Southern cattle tick. Organism_taxid: 6941. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (44 residues) CATH domain: 4.10.140.10
2pf1
Structure of bovine prothrombin fragment 1 refined at 2.25 angstroms resolution
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (121 residues) CATH domain: 2.40.20.10
2pf2
The ca+2 ion and membrane binding structure of the gla domai prothrombin fragment 1
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (146 residues) CATH domain: 2.40.20.10
2pgb
Inhibitor-free human thrombin mutant c191a-c220a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: bhk-21. Expression_system_organ: kidney.
Chains: A, B (35 residues)
2pgq
Human thrombin mutant c191a-c220a in complex with the inhibi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: bhk-21. Expression_system_organ: kidney.
Chains: A, B (43 residues) CATH domain: 4.10.140.10
2pks
Thrombin in complex with inhibitor
Source: Homo sapiens. Human. Synthetic: yes. Other_details: chemically synthesized.
Chains: A, B, C (27 residues)
2pux
Crystal structure of murine thrombin in complex with the ext fragment of murine par3
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: f2, cf2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: kidney cells. Synthetic: yes. Other_details: midwest biotech inc.
Chains: A, B (43 residues) CATH domain: 4.10.140.10
2pv9
Crystal structure of murine thrombin in complex with the ext fragment of murine par4
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: f2, cf2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: kidney cells. Synthetic: yes. Other_details: midwest biotech inc.
Chains: A, B (43 residues) CATH domain: 4.10.140.10
2pw8
Crystal structure of sulfo-hirudin complexed to thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: L, H (27 residues)
2r2m
2-(2-chloro-6-fluorophenyl)acetamides as potent thrombin inh
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (26 residues)
2spt
Differences in the metal ion structure between sr-and ca-pro fragment 1
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (145 residues) CATH domain: 2.40.20.10
2thf
Structure of human alpha-thrombin y225f mutant bound to d-ph chloromethylketone
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932. Expression_system_cell_line: baby hamster kidney cells (bhk
Chains: A, B (26 residues)
2uuf
Thrombin-hirugen binary complex at 1.26a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: this polypeptide chain was chemically synthe
Chains: A, B (28 residues)
2uuj
Thrombin-hirugen-gw473178 ternary complex at 1.32a resolutio
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: this polypeptide chain was chemically synthe
Chains: A, B (28 residues)
2uuk
Thrombin-hirugen-gw420128 ternary complex at 1.39a resolutio
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: this polypeptide chain was chemically synthe
Chains: A, B (28 residues)
2v3h
Thrombin with 3-cycle no f
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: ovary. Synthetic: yes. Hirudo medicinalis. Medicinal leech.
Chains: H, L (250 residues) CATH domains: 2.40.10.10 2.40.10.10
2v3o
Thrombin with 3-cycle with f
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: ovary. Synthetic: yes. Hirudo medicinalis. Medicinal leech.
Chains: H, L (250 residues) CATH domains: 2.40.10.10 2.40.10.10
2zc9
Thrombin in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: the peptide was chemically synthesized.
Chains: L, H (28 residues)
2zda
Exploring thrombin s1 pocket
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (29 residues)
2zdv
Exploring thrombin s1 pocket
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
2zf0
Exploring thrombin s1 pocket
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
2zff
Exploring thrombin s1-pocket
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
2zfp
Thrombin inibition
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
2zfq
Exploring thrombin s3 pocket
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (27 residues)
2zfr
Exploring thrombin s3 pocket
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
2zg0
Exploring thrombin s3 pocket
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (27 residues)
2zgb
Thrombin inhibition
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (27 residues)
2zgx
Thrombin inhibition
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (27 residues)
2zhe
Exploring thrombin s3 pocket
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (27 residues)
2zhf
Exploring thrombin s3 pocket
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (27 residues)
2zhq
Thrombin inhibition
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
2zhw
Exploring thrombin s3 pocket
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (27 residues)
2zi2
Thrombin inhibition
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (27 residues)
2ziq
Thrombin inhibition
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
2znk
Thrombin inhibition
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
2zo3
Bisphenylic thrombin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (27 residues)
3b23
Crystal structure of thrombin-variegin complex: insights of mechanism of inhibition and design of tunable thrombin inhi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: mus musculus. Expression_system_taxid: 10090. Expression_system_cell_line: sp2/0 ag14 mouse myeloma cells crl-1581). Synthetic: yes.
Chains: A, B (29 residues)
3b9f
1.6 a structure of the pci-thrombin-heparin complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: L, H (44 residues) CATH domain: 4.10.140.10
3bef
Crystal structure of thrombin bound to the extracellular fra par1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: f2r, cf2r, par1, tr. Expression_system_taxid: 10029
Chains: A, B, D, E (44 residues) CATH domain: 4.10.140.10
3bei
Crystal structure of the slow form of thrombin in a self_inh conformation
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
Chains: A, B (41 residues) CATH domain: 4.10.140.10
3bf6
Thrombin:suramin complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: human plasma. Synthetic: yes. Other_details: synthetic peptide
Chains: L, H (28 residues)
3biu
Human thrombin-in complex with ub-thr10
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Synthetic: yes. Other_details: synthetic peptide
Chains: L, H (28 residues)
3biv
Human thrombin-in complex with ub-thr11
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: L, H (29 residues)
3bv9
Structure of thrombin bound to the inhibitor fm19
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Synthetic: yes
Chains: A, B (29 residues)
3c1k
Crystal structure of thrombin in complex with inhibitor 15
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421. Other_details: the peptide sequence can be found in hirudo medicinalis
Chain: A (276 residues) CATH domains: 2.40.10.10 2.40.10.10
3c27
Cyanofluorophenylacetamides as orally efficacious thrombin i
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: A, B (26 residues)
3d49
Thrombin inhibition
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo medicinalis.
Chains: L, H (28 residues)
3da9
Crystal structure of thrombin in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes
Chains: A, B (27 residues)
3dd2
Crystal structure of an RNA aptamer bound to human thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes
Chains: L, H (30 residues)
3dhk
Bisphenylic thrombin inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (27 residues)
3dt0
Understanding thrombin inhibition
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (26 residues)
3dux
Understanding thrombin inhibition
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (27 residues)
3e6p
Crystal structure of human meizothrombin desf1
Source: Homo sapiens. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: baby hamster kidney cells.
Chains: L, H (150 residues) CATH domains: 2.40.20.10 4.10.140.10
3edx
Crystal structure of the w215a/e217a mutant of murine thromb
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: f2, cf2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
Chains: A, B, C, D, E, F (42 residues) CATH domain: 4.10.140.10
3ee0
Crystal structure of the w215a/e217a mutant of human thrombin (space group p2(1)2(1)2(1))
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
Chains: A, B (30 residues)
3egk
Knoble inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (27 residues)
3eq0
Thrombin inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (27 residues)
3f68
Thrombin inhibition
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (27 residues)
3gic
Structure of thrombin mutant delta(146-149e) in the free for
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
Chains: A, B (28 residues)
3gis
Crystal structure of na-free thrombin in complex with thrombomodulin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: thbd, thrm.
Chains: A, B, C, D, E, F (46 residues) CATH domain: 4.10.140.10
3hat
Active site mimetic inhibition of thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood. Synthetic: yes
Chains: L, H (36 residues)
3hk3
Crystal structure of murine thrombin mutant w215a/e217a (one molecule in the asymmetric unit)
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: f2, cf2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_organ: baby hamster kidney. Expression_system_cell: bhk cells.
Chains: A, B (30 residues)
3hk6
Crystal structure of murine thrombin mutant w215a/e217a (two molecules in the asymmetric unit)
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: f2, cf2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_organ: baby hamster kidney. Expression_system_cell: bhk cells.
Chains: A, B, C, D (43 residues) CATH domain: 4.10.140.10
3hki
Crystal structure of murine thrombin mutant w215a/e217a in c with the extracellular fragment of human par1
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: f2, cf2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_organ: baby hamster kidney. Expression_system_cell: bhk cells. Homo sapiens.
Chains: A, B, D, E (40 residues) CATH domain: 4.10.140.10
3hkj
Crystal structure of human thrombin mutant w215a/e217a in co the extracellular fragment of human par1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_organ: baby hamster kidney. Expression_system_cell: bhk cells. Gene: f2r, cf2r, par1, tr.
Chains: A, B, D, E (31 residues)
3htc
The structure of a complex of recombinant hirudin and human alpha-thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudinaria manillensis. Organism_taxid: 6419
Chains: L, H (34 residues)
3jz1
Crystal structure of human thrombin mutant n143p in e:na+ fo
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
Chains: A, B (30 residues)
3jz2
Crystal structure of human thrombin mutant n143p in e Form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
Chains: A, B (29 residues)
3k65
Crystal structure of prethombin-2/fragment-2 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: plasma derived. Gene: f2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (80 residues) CATH domain: 2.40.20.10
3ldx
Discovery and clinical evaluation of rwj-671818, a thrombin with an oxyguanidine p1 motif
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (26 residues)
3lu9
Crystal structure of human thrombin mutant s195a in complex extracellular fragment of human par1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2, human. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: f2. Gene: f2r, cf2r, par1, tr. Expression_system_taxid: 10029
Chains: A, B, D, E (44 residues) CATH domain: 4.10.140.10
3nxp
Crystal structure of human prethrombin-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
Chain: A (388 residues) CATH domains: 2.40.20.10 2.40.10.10 2.40.10.10
3p17
Thrombin inhibition by pyridin derivatives
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: the peptide is synthetic fragment.
Chains: L, H (27 residues)
3p6z
Structural basis of thrombin mediated factor v activation: e role of the hirudin-like sequence glu666-glu672 for process heavy chain-b domain junction
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purified from blood plasma. Gene: f5. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, G, H (30 residues)
3p70
Structural basis of thrombin-mediated factor v activation: e role of the hirudin-like sequence glu666-glu672 for process heavy chain-b domain junction
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purified from blood plasma. Gene: f5. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (29 residues)
3pma
2.2 angstrom crystal structure of the complex between bovine and sucrose octasulfate
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Organism_taxid: 9913
Chains: A, B, C, D (29 residues)
3pmb
2.9 angstrom crystal structure of bovine thrombin in tetrago spacegroup
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Organism_taxid: 9913
Chains: A, B, C, D (29 residues)
3pmh
Mechanism of sulfotyrosine-mediated glycoprotein ib interact two distinct alpha-thrombin sites
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: from human plasma. Gene: gp1ba, platelet glycoprotein ib alpha. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227
Chains: A, B (36 residues)
3po1
Thrombin in complex with benzothiazole guanidine
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B, C (27 residues)
3qdz
Crystal structure of the human thrombin mutant d102n in comp the extracellular fragment of human par4.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: mesocricetus auratus. Expression_system_taxid: 10036. Expression_system_cell_line: bhk. Gene: f2rl3, par4. Expression_system_cell_line: bhk
Chains: A, B, C, D (29 residues)
3qgn
The allosteric e -E equilibrium is a key property of the try
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: golden hamster. Expression_system_taxid: 10036. Expression_system_cell_line: bhk cells. Expression_system_cell_line: bhk cells
Chains: A, B (29 residues)
3qlp
X-ray structure of the complex between human alpha thrombin modified thrombin binding aptamer (mtba)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: H, L (259 residues) CATH domains: 2.40.10.10 2.40.10.10
3qto
Thrombin inhibition by pyridin derivatives
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3qtv
Thrombin inhibition by pyridin derivatives
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3qwc
Thrombin inhibition by pyridin derivatives
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3qx5
Thrombin inhibition by pyridin derivatives
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3r3g
Structure of human thrombin with residues 145-150 of murine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10090. Expression_system_organ: baby hamster kidney. Expression_system_organ: baby hamster kidney
Chains: A, B (29 residues)
3rlw
Human thrombin in complex with mi328
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3rly
Human thrombin in complex with mi329
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3rm0
Human thrombin in complex with mi354
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3rm2
Human thrombin in complex with mi003
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3rml
Human thrombin in complex with mi331
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3rmm
Human thrombin in complex with mi332
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3rmn
Human thrombin in complex with mi341
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3rmo
Human thrombin in complex with mi004
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3s7h
Structure of thrombin mutant y225p in the e Form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expression_system_organ: kidney.
Chains: A, B (27 residues)
3s7k
Structure of thrombin mutant y225p in the e form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (31 residues)
3sha
Human thrombin in complex with ubthr97
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3shc
Human thrombin in complex with ubthr101
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3si3
Human thrombin in complex with ubthr103
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3si4
Human thrombin in complex with ubthr104
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3sqe
Crystal structure of prethrombin-2 mutant s195a in the alter form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: E (289 residues) CATH domains: 2.40.10.10 2.40.10.10
3sqh
Crystal structure of prethrombin-2 mutant s195a in the the o
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2, human cdna. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: E (284 residues) CATH domains: 2.40.10.10 2.40.10.10
3sv2
Human thrombin in complex with ubthr105
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3t5f
Human thrombin in complex with mi340
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3tu7
Human alpha-thrombin complexed with n-(methylsulfonyl)-d-phe n-((1-carbamimidoyl-4-piperidinyl)methyl)-l-prolinamide (bm
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Tissue: plasma
Chains: L, H (31 residues)
3u69
Unliganded wild-type human thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: L, H (30 residues)
3u8o
Human thrombin complexed with d-phe-pro-d-arg-d-thr
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Synthetic construct. Organism_taxid: 32630. Other_details: synthetic dl peptide with sequence d-phe-pro thr
Chains: L, H (30 residues)
3u8r
Human thrombin complexed with d-phe-pro-d-arg-ile
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
Chains: L, H (27 residues)
3u8t
Human thrombin complexed with d-phe-pro-d-arg-cys
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes
Chains: L, H (27 residues)
3u98
Human thrombin in complex with mi001
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3u9a
Human thrombin in complex with mi330
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo me
Chains: L, H (28 residues)
3utu
High affinity inhibitor of human thrombin
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (26 residues)
3uwj
Human thrombin in complex with mi353
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic fragment of hirudo medicinalis
Chains: L, H (28 residues)
3vxe
Human alpha-thrombin-bivalirudin complex at pd5.0
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Other_details: fragment produced enzymatically from bivalir
Chains: L, H (27 residues)
3vxf
X/n joint refinement of human alpha-thrombin-bivalirudin com
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Other_details: enzymatically produced from bivalirudin duri crystallization. Crystallization
Chains: L, H (28 residues)
4ax9
Human thrombin complexed with napsagatran, ro0466240
Source: Homo sapiens. Human. Hirudo medicinalis. Medicinal leech. Organ: salivary gland. Human
Chains: H, L (251 residues) CATH domains: 2.40.10.10 2.40.10.10
4ayv
Human thrombin - inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Organ: salivary gland. Organism_taxid: 9606
Chains: A, B (30 residues)
4ayy
Human thrombin - inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Organ: salivary gland. Organism_taxid: 9606
Chains: A, B (30 residues)
4az2
Human thrombin - inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Organ: salivary gland. Organism_taxid: 9606
Chains: A, B (30 residues)
4bah
Thrombin in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: A, B (30 residues)
4bak
Thrombin in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: A, B (28 residues)
4bam
Thrombin in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: A, B (28 residues)
4ban
Thrombin in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Organism_taxid: 6421
Chains: A, B (28 residues)
4bao
Thrombin in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Organism_taxid: 6421
Chains: A, B (28 residues)
4baq
Thrombin in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: A, B (28 residues)
4boh
Madanins (merops i53) are cleaved by thrombin and factor xa
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Haemaphysalis longicornis. Organism_taxid: 44386. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, H, L (249 residues) CATH domains: 2.40.10.10 2.40.10.10
4ch2
Low-salt crystal structure of a thrombin-gpibalpha peptide complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star, plyss. Synthetic: yes.
Chains: A, B, C, D (32 residues)
4ch8
High-salt crystal structure of a thrombin-gpibalpha peptide complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star, plyss. Synthetic: yes.
Chains: A, B, C, D, E, F, G, H (26 residues)
4dih
X-ray structure of the complex between human alpha thrombin thrombin binding aptamer in the presence of sodium ions
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Synthetic DNA. Organism_taxid: 32630
Chains: L, H (27 residues)
4dii
X-ray structure of the complex between human alpha thrombin thrombin binding aptamer in the presence of potassium ions
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Synthetic DNA. Organism_taxid: 32630
Chains: L, H (27 residues)
4dt7
Crystal structure of thrombin bound to the activation domain qedqvdprlidgkmtrrgds of protein c
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2, human. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chains: A, B, C, D (32 residues)
4dy7
Crystal structures of protease nexin-1 in complex with s195a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetinae gen. Sp.. Expression_system_taxid: 36483. Expression_system_organ: kidney. Expression_system_cell: baby hamster kidney (bhk) cells. Gene: serpine2, pi7, pn1.
Chains: A, B, D, E (45 residues) CATH domain: 4.10.140.10
4e05
Anophelin from the malaria vector inhibits thrombin through reverse-binding mechanism
Source: Homo sapiens. Human. Organism_taxid: 9606. Anopheles albimanus. New world malaria mosquito. Organism_taxid: 7167. Gene: anophelin. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: L, H (29 residues)
4e06
Anophelin from the malaria vector inhibits thrombin through reverse-binding mechanism
Source: Homo sapiens. Human. Organism_taxid: 9606. Anopheles albimanus. New world malaria mosquito. Organism_taxid: 7167. Gene: anophelin. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: L, H (28 residues)
4e7r
Thrombin in complex with 3-amidinophenylalanine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: synthetic construct
Chains: L, M, H, G (28 residues)
4h6s
Crystal structure of thrombin mutant e14ea/d14la/e18a/s195a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (31 residues)
4h6t
Crystal structure of prethrombin-2 mutant e14ea/d14la/e18a/s
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (293 residues) CATH domains: 2.40.10.10 2.40.10.10
4hfp
Structure of thrombin mutant s195a bound to the active site argatroban
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, C, D (29 residues)
4hfy
Structure of prethrombin-2 mutant s195a bound to the active inhibitor argatroban
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (284 residues) CATH domains: 2.40.10.10 2.40.10.10
4htc
The refined structure of the hirudin-thrombin complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chains: L, H (33 residues)
4hzh
Structure of recombinant gla-domainless prothrombin mutant s
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: bhk cell
Chains: A, B (392 residues) CATH domains: 2.40.20.10 2.40.10.10 2.40.10.10
4i7y
Crystal structure of human alpha thrombin in complex with a aptamer bound to exosite ii
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Synthetic DNA. Organism_taxid: 32630
Chains: H, L (250 residues) CATH domains: 2.40.10.10 2.40.10.10
4loy
Crystal structure analysis of thrombin in complex with compo 5-chlorothiophene-2-carboxylic acid [(s)-2-[2-methyl-3-(2- oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperaz 3-oxopropyl]amide (sar107375)
Source: Homo sapiens. Human. Organism_taxid: 9606. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Synthetic: yes. Organism_taxid: 9606
Chains: H, L (250 residues) CATH domains: 2.40.10.10 2.40.10.10
4lz1
X-ray structure of the complex between human thrombin and th deletion mutant lacking thymine 12 nucleobase
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Other_details: deletion mutant of the thrombin binding apta
Chains: L, H (28 residues)
4lz4
X-ray structure of the complex between human thrombin and th deletion mutant lacking thymine 3 nucleobase
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Other_details: synthetic DNA
Chains: A, B, C, D (34 residues)
4mlf
Crystal structure for the complex of thrombin mutant d102n a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: kidney fibroblast cells (bhk-21). Hirudo medicinalis. Medicinal leech.
Chains: A, B (32 residues)
4n3l
Crystal structure of thrombin in complex with a novel glucos conjugated potent inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421
Chains: L, H (26 residues)
4nze
Crystal structure of thrombin in complex with a novel tetra- glucopyranoside-conjugated potent inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421. Other_details: hirugen was bought by biochem (shanghai)
Chains: H, L (250 residues) CATH domains: 2.40.10.10 2.40.10.10
4nzq
Crystal structure of ca2+-free prothrombin deletion mutant r 146-167
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_cell: baby hamster kidney (bhk)
Chain: A (508 residues)
4o03
Crystal structure of ca2+ bound prothrombin deletion mutant 146-167
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_cell: baby hamster kidney (bhk)
Chain: A (539 residues)
4thn
The crystal structure of alpha-thrombin-hirunorm iv complex novel specificity site recognition mode.
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: seed. Tissue: plasma.
Chains: L, H (36 residues)
5gds
Hirunorms are true hirudin mimetics. The crystal structure o alpha-thrombin:hirunorm v complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: plasma.
Chains: L, H (36 residues)
7kme
Crystal structure of human alpha-thrombin inhibited with sel
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Synthetic: yes
Chains: L, H (25 residues)
8kme
Crystal structure of human alpha-thrombin inhibited with sel
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Synthetic: yes
Chains: 1, 2 (26 residues)