EC 3.4.21.5 - Thrombin

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 3.4.21.5

Names

Accepted name:
thrombin
Other names:
β-thrombin
γ-thrombin
E thrombin
activated blood-coagulation factor II
blood-coagulation factor IIa
factor IIa
fibrinogenase
thrombase
thrombin-C
thrombofort
topical
tropostasin
Systematic name:
-

Reaction

Comments:

Formed from prothrombin. More selective than trypsin and plasmin. In peptidase family S1 (trypsin family). Formerly EC 3.4.4.13.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003809
CAS Registry Number: 9002-04-4
UniProtKB/Swiss-Prot:

References

  1. Baughman, D.J.
    Thrombin assay.
    Methods Enzymol. 19: 145-157 (1970).
  2. Magnusson, S.
    Bovine prothrombin and thrombin.
    Methods Enzymol. 19: 157-184 (1970).
  3. Miller, K.D.
    Horse prothrombin.
    Methods Enzymol. 19: 140-145 (1970).
  4. Lundblad, R.L., Kingdon, H.S. and Mann, K.G.
    Thrombin.
    Methods Enzymol. 45: 156-176 (1976). [PMID: 1011989]
  5. Mann, K.G.
    Prothrombin.
    Methods Enzymol. 45: 123-156 (1976). [PMID: 1011988]
  6. Davie, E.W., Fujikawa, K., Kurachi, K. and Kisiel, W.
    The role of serine proteases in the blood coagulation cascade.
    Adv. Enzymol. 48: 277-318 (1979). [PMID: 367103]
  7. Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C.
    Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
    Biochemistry 23: 644-650 (1984). [PMID: 6370301]
  8. MacGillivray, R.T.A. and Davie, E.W.
    Characterization of bovine prothrombin mRNA and its translation product.
    Biochemistry 23: 1626-1634 (1984). [PMID: 6326805]

[EC 3.4.21.5 created 1961 as EC 3.4.4.13, transferred 1972 to EC 3.4.21.5]