PDBsum entry 6p9c

Hydrolase/antibiotic

PDB id: 6p9c

Contents

Protein chains

242 a.a.

Ligands

4J6 ×2

O6P ×2

Metals

_CD ×2

_CL ×4

_CA ×3

Waters ×181

PDB id:

6p9c

Name:

Hydrolase/antibiotic

Title:

Oxa-48 carbapanemase, doripenem complex

Structure:

Beta-lactamase. Chain: a, b. Engineered: yes

Source:

Klebsiella pneumoniae. Organism_taxid: 573. Gene: bla oxa-48, blaoxa-48, kpe71t_00045. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.90Å R-factor: 0.197 R-free: 0.241

Authors:

C.A.Smith,S.B.Vakulenko

Key ref:

C.A.Smith et al. Structural insights into the mechanism of carbapenema activity of the oxa-48 beta-Lactamase.. Antimicrob agents chemother, . PubMed id: 31358584

Date:

10-Jun-19 Release date: 07-Aug-19

Protein chains

Q6XEC0  (BLO48_KLEPN) -  Beta-lactamase OXA-48 from Klebsiella pneumoniae

Seq: 265 a.a.

Struc: 242 a.a.

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)