PDBsum entry 6e4e

Oxidoreductase/inhibitor

PDB id: 6e4e

Contents

Protein chain

159 a.a.

Ligands

NAP

MMV

Waters ×117

PDB id:

6e4e

Name:

Oxidoreductase/inhibitor

Title:

Crystal structure of dihydrofolate reductase from staphylococcus aureus mw2 bound to NADP and p218

Structure:

Dihydrofolate reductase. Chain: a. Synonym: dhfr. Engineered: yes

Source:

Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.90Å R-factor: 0.182 R-free: 0.224

Authors:

Seattle Structural Genomics Center For Infectious Disease (Ssgcid)

Key ref:

T.E.Edwards et al. Crystal structure of dihydrofolate reductase from staphylococcus aureus mw2 bound to NADP and p218. To be published, .

Date:

17-Jul-18 Release date: 25-Jul-18

Protein chain

P0A017  (DYR_STAAU) -  Dihydrofolate reductase from Staphylococcus aureus

Seq: 159 a.a.

Struc: 159 a.a.

Enzyme reactions

• Enzyme class: E.C.1.5.1.3 - dihydrofolate reductase.
• Pathway: Folate Coenzymes
• Reaction: (6S)-5,6,7,8-tetrahydrofolate + NADP⁺ = 7,8-dihydrofolate + NADPH + H⁺

(6S)-5,6,7,8-tetrahydrofolate + NADP(+) (Bound ligand (Het Group name = NAP) corresponds exactly) = 7,8-dihydrofolate + NADPH + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site