_EC 1.5.1.3 Dihydrofolate reductase. 333 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,646 PDB entries]
EC 1.5.-.- Acting on the CH-NH group of donors. [619 PDB entries]
EC 1.5.1.- With NAD(+) or NADP(+) as acceptor. [481 PDB entries]
EC 1.5.1.3 Dihydrofolate reductase. [333 PDB entries]    
1ai9

Pathway: Folate Coenzymes
Reaction: 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + Nadph.
 


5,6,7,8-tetrahydrofolate
+
NADP(+)
=
7,8-dihydrofolate
+
NADPH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Tetrahydrofolate dehydrogenase.
Comments: The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. Formerly Ec 1.5.1.4.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 333 PDB entries in enzyme class E.C.1.5.1.3

  PDB code Protein
1ai9
Candida albicans dihydrofolate reductase
Source: Candida albicans. Organism_taxid: 5476. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: de3.
Chains: A, B (192 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1ao8
Dihydrofolate reductase complexed with methotrexate, nmr, 21 structures
Source: Lactobacillus casei. Organism_taxid: 1582. Strain: methotrexate-resistant. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (162 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
1aoe
Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) and 1,3-diamino-7-(1-ethyepropye)-7h-pyrralo-[3,2- f]quinazoline (gw345)
Source: Candida albicans. Organism_taxid: 5476. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (192 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1boz
Structure-based design and synthesis of lipophilic 2,4- diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductase and potential antitumor agents
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1bzf
Nmr solution structure and dynamics of the complex of lactobacillus casei dihydrofolate reductase with the new lipophilic antifolate drug trimetrexate, 22 structures
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (162 residues) CATH domain: 3.40.430.10
1cd2
Ligand induced conformational changes in the crystal structures of pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (206 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
1cz3
Dihydrofolate reductase from thermotoga maritima
Source: Thermotoga maritima. Organism_taxid: 2336. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (164 residues) CATH domain: 3.40.430.10
1d1g
Dihydrofolate reductase from thermotoga maritima
Source: Thermotoga maritima. Organism_taxid: 2336. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: genomic library
Chains: A, B (164 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
1d8r
Structural studies on bio-active compounds. Crystal structure and molecular modeling studies on the pneumocystis carinii dihydrofolate reductase cofactor complex with tab, a highly selective antifolate.
Source: Pneumocystis carinii. Gene: c-DNA p.Carinii dhfr. Expressed in: escherichia coli.
Chain: A (205 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1daj
Comparison of ternary complexes of pneumocystis carinii and wild type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3d]pyrimidine antifolate
Source: Pneumocystis carinii. Organism_taxid: 4754. Gene: c-DNA pneumocystis carinii dhf. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (206 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MOT is 52.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
1ddr
Molecule: dihydrofolate reductase (E.C.1.5.1.3) complexed wi methotrexate and urea
Source: Escherichia coli. Organism_taxid: 37762. Strain: b
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group MTX is 91.18% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
1dds
Molecule: dihydrofolate reductase (E.C.1.5.1.3) complexed with methotrexate
Source: Escherichia coli. Organism_taxid: 562.
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
1df7
Dihydrofolate reductase of mycobacterium tuberculosis comple NADPH and methotrexate
Source: Mycobacterium tuberculosis. Organism_taxid: 1773
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.18% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
1dg5
Dihydrofolate reductase of mycobacterium tuberculosis comple NADPH and trimethoprim
Source: Mycobacterium tuberculosis. Organism_taxid: 1773
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1dg7
Dihydrofolate reductase of mycobacterium tuberculosis comple NADPH and 4-bromo wr99210
Source: Mycobacterium tuberculosis. Organism_taxid: 1773
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1dg8
Dihydrofolate reductase of mycobacterium tuberculosis comple NADPH
Source: Mycobacterium tuberculosis. Organism_taxid: 1773
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1dhf
Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazofolate
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: A, B (182 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
1dhi
Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
1dhj
Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
1dis
Dihydrofolate reductase (E.C.1.5.1.3) complex with brodimoprim-4,6-dicarboxylate
Source: Lactobacillus casei. Organism_taxid: 1582. Strain: methotrexate-resistant. Gene: potential. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (162 residues) CATH domain: 3.40.430.10
1diu
Dihydrofolate reductase (E.C.1.5.1.3) complex with brodimoprim-4,6-dicarboxylate
Source: Lactobacillus casei. Organism_taxid: 1582. Strain: methotrexate-resistant. Gene: potential. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (162 residues) CATH domain: 3.40.430.10
1dlr
Methotrexate-resistant variants of human dihydrofolate reductase with substitution of leucine 22: kinetics, crystallography and potential as selectable markers
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: potential
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1dls
Methotrexate-resistant variants of human dihydrofolate reductase with substitution of leucine 22: kinetics, crystallography and potential as selectable markers
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: potential
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
1dr1
2.2 angstroms crystal structure of chicken liver dihydrofola reductase complexed with NADP+ and biopterin
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: liver
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
1dr2
2.3 angstroms crystal structure of chicken liver dihydrofola reductase complexed with thionadp+ and biopterin
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: liver
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group TAP is 95.92% similar to enzyme reactant NADP(+)
1dr3
2.3 angstroms crystal structure of chicken liver dihydrofola reductase complexed with thionadp+ and biopterin
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: liver
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group TAP is 95.92% similar to enzyme reactant NADP(+)
1dr4
Crystal structures of organomercurial-activated chicken live dihydrofolate reductase complexes
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: liver
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
1dr5
Crystal structures of organomercurial-activated chicken liver dihydrofolate reductase complexes
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: liver
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
1dr6
Crystal structures of organomercurial-activated chicken liver dihydrofolate reductase complexes
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: liver
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
1dr7
Crystal structures of organomercurial-activated chicken liver dihydrofolate reductase complexes
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: liver
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
1dra
Crystal structure of unliganded escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
1drb
Crystal structure of unliganded escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
1dre
Dihydrofolate reductase complexed with methotrexate and nicotinamide adenine dinucleotide phosphate (oxidized form)
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
1drf
Crystal structure of human dihydrofolate reductase complexed with folate
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
1drh
Isomorphous crystal structures of escherichia coli dihydrofolate reductase complexed with folate, 5- deazafolate and 5,10-dideazatetrahydrofolate: mechanistic implications
Source: Escherichia coli. Organism_taxid: 562
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
1dyh
Isomorphous crystal structures of escherichia coli dihydrofolate reductase complexed with folate, 5- deazafolate and 5,10-dideazatetrahydrofolate: mechanistic implications
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group DZF is 93.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
1dyi
Isomorphous crystal structures of escherichia coli dihydrofolate reductase complexed with folate, 5- deazafolate and 5,10-dideazatetrahydrofolate: mechanistic implications
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
1dyj
Isomorphous crystal structures of escherichia coli dihydrofolate reductase complexed with folate, 5- deazafolate and 5,10-dideazatetrahydrofolate: mechanistic implications
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (159 residues) CATH domain: 3.40.430.10
1dyr
The structure of pneumocystis carinii dihydrofolate reductase to 1.9 angstroms resolution
Source: Pneumocystis carinii. Organism_taxid: 4754. Gene: c-DNA p.Carinii dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: rat-derived
Chain: A (205 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1e26
Design, synthesis and x-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent.
Source: Pneumocystis carinii. Organism_taxid: 4754. Gene: c-DNA p.Carinii dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (205 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group GPB is 40.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
1hfp
Comparison of ternary crystal complexes of human dihydrofola reductase with NADPH and a classical antitumor furopyrimdin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: potential. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MOT is 52.38% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
1hfq
Comparison of ternary crystal complexes of human dihydrofola reductase with NADPH and a classical antitumor furopyrimdin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: potential. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MOT is 52.38% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
1hfr
Comparison of ternary crystal complexes of human dihydrofola reductase with NADPH and a classical antitumor furopyrimdin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: potential. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MOT is 52.38% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
1ia1
Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) and 5-(phenylsulfanyl)-2,4-quinazolinediamine (gw997)
Source: Candida albicans. Organism_taxid: 5476. Gene: dfr1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (192 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1ia2
Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) and 5-[(4-methylphenyl)sulfanyl]-2,4- quinazolinediamine (gw578)
Source: Candida albicans. Organism_taxid: 5476. Gene: dfr1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (192 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1ia3
Candida albicans dihydrofolate reductase complex in which the dihydronicotinamide moiety of dihydro-nicotinamide- adenine-dinucleotide phosphate (NADPH) is displaced by 5- [(4-tert-butylphenyl)sulfanyl]-2,4-quinazolinediamine (gw995)
Source: Candida albicans. Organism_taxid: 5476. Gene: dfr1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (192 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP is 72.00% similar to enzyme reactant NADP(+)
1ia4
Candida albicans dihydrofolate reductase complex in which the dihydronicotinamide moiety of dihydro-nicotinamide- adenine-dinucleotide phosphate (NADPH) is displaced by 5- {[4-(4-morpholinyl)phenyl]sulfanyl}-2,4-quinazolinediamin (gw2021)
Source: Candida albicans. Organism_taxid: 5476. Gene: dfr1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (192 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP is 72.00% similar to enzyme reactant NADP(+)
1j3i
Wild-type plasmodium falciparum dihydrofolate reductase- thymidylate synthase (pfdhfr-ts) complexed with wr99210, NADPH, and dump
Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (223 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1j3j
Double mutant (c59r+s108n) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with pyrimethamine, NADPH, and dump
Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (221 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1j3k
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with wr99210, NADPH, and dump
Source: Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (221 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1jol
The crystal structure of the binary complex between folinic acid (leucovorin) and e. Coli dihydrofolate reductase
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group FFO is 94.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
1jom
The crystal structure of the binary complex between folinic acid (leucovorin) and e. Coli dihydrofolate reductase
Source: Escherichia coli. Organism_taxid: 562
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group FFO is 94.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
1juv
Crystal structure analysis of dihydrofolate reductase from bacteriophage t4
Source: Enterobacteria phage t4. Organism_taxid: 10665. Gene: frd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (193 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1klk
Crystal structure of pneumocystis carinii dihydrofolate redu ternary complex with pt653 and NADPH
Source: Pneumocystis carinii. Organism_taxid: 4754. Organ: lung. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (203 residues) CATH domain: 3.40.430.10
1kms
Human dihydrofolate reductase complexed with NADPH and 6- ([5-quinolylamino]methyl)-2,4-diamino-5-methylpyrido[2,3- d]pyrimidine (sri-9439), a lipophilic antifolate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (185 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group LIH is 62.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
1kmv
Human dihydrofolate reductase complexed with NADPH and (z)- 6-(2-[2,5-dimethoxyphenyl]ethen-1-yl)-2,4-diamino-5- methylpyrido[2,3-d]pyrimidine (sri-9662), a lipophilic antifolate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1lud
Solution structure of dihydrofolate reductase complexed with trimethoprim and NADPH, 24 structures
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (162 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1ly3
Analysis of quinazoline and pyridopyrimidine n9-c10 reversed bridge antifolates in complex with NADP+ and pneumocystis carinii dihydrofolate reductase
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (206 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
1ly4
Analysis of quinazoline and pyrido[2,3d]pyrimidine n9-c10 reversed bridge antifolates in complex with NADP+ and pneumocystis carinii dihydrofolate reductase
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (205 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
1m78
Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) and 5-chloryl-2,4,6-quinazolinetriamine (gw1225)
Source: Candida albicans. Organism_taxid: 5476. Gene: dfr1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (192 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1m79
Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) and 5-(4-methoxyphenoxy)-2,4-quinazolinediamine (gw1466)
Source: Candida albicans. Organism_taxid: 5476. Gene: dfr1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (192 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1m7a
Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) and 7-[2-methoxy-1-(methoxymethyl)ethyl]-7h- pyrrolo[3,2-f] quinazoline-1,3-diamine (gw557)
Source: Candida albicans. Organism_taxid: 5476. Gene: dfr1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (192 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1mvs
Analysis of two polymorphic forms of a pyrido[2,3- d]pyrimidine n9-c10 reverse-bridge antifolate binary complex with human dihydrofolate reductase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
1mvt
Analysis of two polymorphic forms of a pyrido[2,3- d]pyrimidine n9-c10 reverse-bridge antifolate binary complex with human dihydrofolate reductase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
1ohj
Human dihydrofolate reductase, monoclinic (p21) crystal form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: potential. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group COP is 64.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
1ohk
Human dihydrofolate reductase, orthorhombic (p21 21 21) crystal form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: potential. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group COP is 64.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
1pd8
Analysis of three crystal structure determinations of a 5- methyl-6-n-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group CO4 is 46.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
1pd9
Analysis of three crystal structure determinations of a 5- methyl-6-n-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group CO4 is 46.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
1pdb
Analysis of three crystal structure determinations of a 5- methyl-6-n-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (186 residues) CATH domain: 3.40.430.10
1ra1
Dihydrofolate reductase complexed with nicotinamide adenine dinucleotide phosphate (reduced form)
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP is 64.00% similar to enzyme reactant NADP(+)
1ra2
Dihydrofolate reductase complexed with folate and nicotinamide adenine dinucleotide phosphate (oxidized form)
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
1ra3
Dihydrofolate reductase complexed with methotrexate and nicotinamide adenine dinucleotide phosphate (oxidized form)
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP is 70.00% similar to enzyme reactant NADP(+)
1ra8
Dihydrofolate reductase complexed with folate and 2- monophosphoadenosine 5'-diphosphoribose
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group ATR is 64.00% similar to enzyme reactant NADP(+)
1ra9
Dihydrofolate reductase complexed with nicotinamide adenine dinucleotide phosphate (oxidized form)
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP is 64.00% similar to enzyme reactant NADP(+)
1rb2
Dihydrofolate reductase complexed with folate and nicotinamide adenine dinucleotide phosphate (oxidized form)
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
1rb3
Dihydrofolate reductase complexed with methotrexate and nicotinamide adenine dinucleotide phosphate (oxidized form)
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP is 81.00% similar to enzyme reactant NADP(+)
1rc4
Dihydrofolate reductase complexed with 5,10- dideazatetrahydrofolate and nicotinamide adenine dinucleotide phosphate (oxidized form)
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP is 93.00% similar to enzyme reactant NADP(+)
1rd7
Dihydrofolate reductase complexed with folate
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
1re7
Dihydrofolate reductase complexed with folate
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
1rf7
Structure of dihydrofolate reductase complexed with dihydrofolate
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group DHF corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
1rg7
Dihydrofolate reductase complexed with methotrexate
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
1rh3
Dihydrofolate reductase complexed with methotrexate and nicotinamide adenine dinucleotide phosphate (reduced form)
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
1rx1
Dihydrofolate reductase (E.C.1.5.1.3) complexed with nicotinamide adenine dinucleotide phosphate (reduced form)
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
1rx2
Dihydrofolate reductase (E.C.1.5.1.3) complexed with with folate and nicotinamide adenine dinucleotide phosphate (oxidized form)
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
1rx3
Dihydrofolate reductase (E.C.1.5.1.3) complexed with methotrexate and nicotinamide adenine dinucleotide phosphate (reduced form)
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
1rx4
Dihydrofolate reductase (E.C.1.5.1.3) complexed with 5,10- dideazatetrahydrofolate and 2'-monophosphoadenosine 5'- diphosphoribose
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP is 81.00% similar to enzyme reactant NADP(+)
1rx5
Dihydrofolate reductase (E.C.1.5.1.3) complexed with 5,10- dideazatetrahydrofolate
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
1rx6
Dihydrofolate reductase (E.C.1.5.1.3) complexed with 5,10- dideazatetrahydrofolate and nicotinamide adenine dinucleotide phosphate (reduced form)
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP is 81.00% similar to enzyme reactant NADP(+)
1rx7
Structure of dihydrofolate reductase complexed with folate
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
1rx8
Dihydrofolate reductase complexed with folate and 2'- monophosphoadenosine 5'-diphosphoribose
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP is 64.00% similar to enzyme reactant NADP(+)
1rx9
Dihydrofolate reductase (E.C.1.5.1.3) complexed with nicotinamide adenine dinucleotide phosphate (oxidized form)
Source: Escherichia coli. Organism_taxid: 562. Strain: rt500. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP is 66.00% similar to enzyme reactant NADP(+)
1s3u
Structure determination of tetrahydroquinazoline antifolates in complex with human and pneumocystis carinii dihydrofolate reductase: correlations of enzyme selectivity and stereochemistry
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (186 residues) CATH domain: 3.40.430.10
1s3v
Structure determination of tetrahydroquinazoline antifolates in complex with human and pneumocystis carinii dihydrofolate reductase: correlations of enzyme selectivity and stereochemistry
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (186 residues) CATH domain: 3.40.430.10
1s3w
Structure determination of tetrahydroquinazoline antifoaltes in complex with human and pneumocystis carinii dihydrofolate reductase: correlations of enzyme selectivity and stereochemistry
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
1s3y
Structure determination of tetrahydroquinazoline antifolates in complex with human and pneumocystis carinii dihydrofolate reductase: correlations of enzyme selectivity and stereochemistry
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (206 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
1tdr
Expression, characterization, and crystallographic analysis of telluromethionyl dihydrofolate reductase
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
1u70
Understanding the role of leu22 variants in methotrexate resistance: comparison of wild-type and leu22arg variant mouse and human dihydrofolate reductase
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
1u71
Understanding the role of leu22 variants in methotrexate resistance: comparison of wild-type and leu22arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (186 residues) CATH domain: 3.40.430.10
1u72
Understanding the role of leu22 variants in methotrexate resistance: comparison of wild-type and leu22arg variant mouse and human dihydrfolate reductase ternary crystal complexes with methotrexate and NADPH
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
1vdr
Dihydrofolate reductase
Source: Haloferax volcanii. Organism_taxid: 2246. Other_details: formerly halobacterium volcanii
Chains: A, B (157 residues) CATH domain: 3.40.430.10
1vie
Structure of dihydrofolate reductase
Source: Escherichia coli. Organism_taxid: 562. Strain: tmp-resistant, containing r67 dhfr overproducing plasmid plz1. Gene: synthetic gene. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (60 residues) CATH domain: 2.30.30.60
1vif
Structure of dihydrofolate reductase
Source: Escherichia coli. Organism_taxid: 562. Strain: tmp-resistant, containing r67 dhfr overproducing plasmid plz1. Gene: synthetic gene. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (60 residues) CATH domain: 2.30.30.60
Bound ligand:   Het Group FOL is 40.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
1vj3
Structural studies on bio-active compounds. Crystal structure and molecular modeling studies on the pneumocystis carinii dihydrofolate reductase cofactor complex with tab, a highly selective antifolate.
Source: Pneumocystis carinii. Organism_taxid: 4754. Gene: c-DNA p.Carinii dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (205 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1yho
Solution structure of human dihydrofolate reductase complexed with trimethoprim and NADPH, 25 structures
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1zdr
Dhfr from bacillus stearothermophilus
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (161 residues) CATH domain: 3.40.430.10
2ano
Crystal structure of e.Coli dihydrofolate reductase in compl NADPH and the inhibitor ms-sh08-17
Source: Escherichia coli. Organism_taxid: 562. Gene: fola, tmra. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2anq
Crystal structure of e.Coli dhfr in complex with NADPH and t inhibitor compound 10a.
Source: Escherichia coli. Organism_taxid: 562. Gene: fola, tmra. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2bl9
X-ray crystal structure of plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative
Source: Plasmodium vivax. Organism_taxid: 5855. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (216 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2bla
Sp21 double mutant p. Vivax dihydrofolate reductase in complex with pyrimethamine
Source: Plasmodium vivax. Organism_taxid: 5855. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (217 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2blb
X-ray crystal structure of plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative
Source: Plasmodium vivax. Organism_taxid: 5855. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (218 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2blc
Sp21 double mutant p. Vivax dihydrofolate reductase in complex with des-chloropyrimethamine
Source: Plasmodium vivax. Organism_taxid: 5855. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (215 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2c2s
Human dihydrofolate reductase complexed with NADPH and 2,4- diamino-5-(1-o-carboranylmethyl)-6-methylpyrimidine, a novel boron containing, nonclassical antifolate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2c2t
Human dihydrofolate reductase complexed with NADPH and 2,4- diamino-5-((7,8-dicarbaundecaboran-7-yl)methyl)-6- methylpyrimidine, a novel boron containing, nonclassical antifolate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2cd2
Ligand induced conformational changes in the crystal structures of pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+
Source: Pneumocystis carinii. Organism_taxid: 4754. Variant: bacteria. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (206 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
2cig
Dihydrofolate reductase from mycobacterium tuberculosis inhibited by the acyclic 4r isomer of inh-NADP a derivative of the prodrug isoniazid.
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group 1DG is 85.00% similar to enzyme reactant NADP(+)
2d0k
Methionine-free mutant of escherichia coli dihydrofolate reductase
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
2dhf
Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazofolate
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: A, B (182 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group DZF is 93.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
2drc
Investigation of the functional role of tryptophan-22 in escherichia coli dihydrofolate reductase by site-directed mutagenesis
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
2fzh
New insights into dihydrofolate reductase interactions: anal pneumocystis carinii and mouse dhfr complexes with NADPH an highly potent trimethoprim derivatives
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (206 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2fzi
New insights into dhfr interactions: analysis of pneumocysti and mouse dhfr complexes with NADPH and two highly potent trimethoprim derivatives
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (206 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2fzj
New insights into dhfr interactions: analysis of pneumocysti and mouse dhfr complexes with NADPH and two highly potent trimethoprim derivatives
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2gqv
High-resolution structure of a plasmid-encoded dihydrofolate reductase: pentagonal network of water molecules in the d2-symmetric active site
Source: Escherichia coli. Organism_taxid: 562. Strain: tmp-resistant, containing r67 dhfr overproducing plasmid plz1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (59 residues) CATH domain: 2.30.30.60
2h2q
Crystal structure of trypanosoma cruzi dihydrofolate reducta thymidylate synthase
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: y. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (514 residues) CATH domains: 3.40.430.10 3.30.572.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
2hm9
Solution structure of dihydrofolate reductase complexed with trimethoprim, 33 structures
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: fola, dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (162 residues) CATH domain: 3.40.430.10
2hqp
Solution structure of l.Casei dihydrofolate reductase complexed with NADPH, 32 structures
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: fola, dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (162 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2inq
Neutron crystal structure of escherichia coli dihydrofolate bound to the anti-cancer drug, methotrexate
Source: Escherichia coli k12. Organism_taxid: 83333. Strain: k-12. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group MT1 is 86.11% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
2ith
Nmr structure of haloferax volcanii dhfr
Source: Haloferax volcanii. Organism_taxid: 2246. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (162 residues) CATH domain: 3.40.430.10
2jyb
Binary hvdhfr1:folate complex
Source: Haloferax volcanii. Organism_taxid: 2246. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (162 residues) CATH domain: 3.40.430.10
2kgk
Solution structure of bacillus anthracis dihydrofolate reductase
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 1392. Gene: dfra, bas2083, ba_2237, gbaa2237. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (162 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
2l28
Solution structure of lactobacillus casei dihydrofolate redu form, 25 conformers
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: fola, dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (162 residues) CATH domain: 3.40.430.10
2lf1
Solution structure of l. Casei dihydrofolate reductase compl NADPH, 30 structures
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: fola, dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (162 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2p4t
Structure of the q67h mutant of r67 dihydrofolate reductase- NADP+ complex reveals a novel cofactor binding mode
Source: Escherichia coli. Organism_taxid: 562. Strain: tmp-resistant, containing r67 dhfr overproducing plasmid plz1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (58 residues) CATH domain: 2.30.30.60
Bound ligand:   Het Group NAP is 54.00% similar to enzyme reactant NADP(+)
2qk8
Crystal structure of the anthrax drug target, bacillus anthr dihydrofolate reductase
Source: Bacillus anthracis str.. Organism_taxid: 260799. Strain: sterne. Gene: dfra. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. With t7 promoter and n-terminal hexahistidine and sumo tags
Chain: A (162 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group MTX is 91.18% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
2rh2
High resolution dhfr r-67
Source: Escherichia coli. Expressed in: escherichia coli. Other_details: tmp-resistant, containing r67 dhfr overproducing plasmid plz1
Chain: A (58 residues) CATH domain: 2.30.30.60
2rk1
Dhfr r67 complexed with NADP and dihydrofolate
Source: Escherichia coli. Strain: tmp-resistant, containing r67 dhfr overproducing plasmid plz1
Chain: A (58 residues) CATH domain: 2.30.30.60
Bound ligands:   Het Group DHF is 40.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
2rk2
Dhfr r-67 complexed with NADP
Source: Escherichia coli. Strain: tmp-resistant, containing r67 dhfr overproducing pl plz1
Chain: A (58 residues) CATH domain: 2.30.30.60
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
2w3a
Human dihydrofolate reductase complexed with NADPH and trimethoprim
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2w3b
Human dihydrofolate reductase complexed with NADPH and a lipophilic antifolate selective for mycobacterium avium dhfr, 6-((2,5-diethoxyphenyl)aminomethyl)-2,4-diamino-5- methylpyrido(2,3-d)pyrimidine (sri-8686)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (185 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
2w3m
Human dihydrofolate reductase complexed with NADPH and folate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
2w3v
Mycobacterium avium dihydrofolate reductase complexed with NADPH and trimethoprim
Source: Mycobacterium avium. Organism_taxid: 1764. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: strain obtained from the aids research and r reagent program, division of aids, niaid, nih, catalog num 1786.
Chain: A (165 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2w3w
Mycobacterium avium dihydrofolate reductase complexed with NADPH and a lipophilic antifolate selective for m. Avium dhfr, 6-((2,5-diethoxyphenyl)aminomethyl)-2,4-diamino-5- methylpyrido(2,3-d)pyrimidine (sri-8686)
Source: Mycobacterium avium. Organism_taxid: 1764. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: strain obtained from the aids research and r reagent program, division of aids, niaid, nih, catalog num 1786.
Chain: A (165 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group VG9 is 47.50% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
2w9g
Wild-type staphylococcus aureus dhfr in complex with NADPH and trimethoprim
Source: Staphylococcus aureus. Organism_taxid: 1280. Strain: mu-50. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2w9h
Wild-type staphylococcus aureus dhfr in complex with trimethoprim
Source: Staphylococcus aureus. Organism_taxid: 1280. Strain: mu-50. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.40.430.10
2w9s
Staphylococcus aureus s1:dhfr in complex with trimethoprim
Source: Staphylococcus aureus. Organism_taxid: 1280. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2w9t
Staphylococcus aureus s1:dhfr
Source: Staphylococcus aureus. Organism_taxid: 1280. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (159 residues) CATH domain: 3.40.430.10
2zza
Moritella profunda dihydrofolate reductase complex with NADP+ and folate
Source: Moritella profunda. Organism_taxid: 111291. Strain: 2674t. Gene: dyra. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (161 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
3cd2
Ligand induced conformational changes in the crystal structures of pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (206 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
3cl9
Structure of bifunctional tcdhfr-ts in complex with mtx
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: y. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (505 residues) CATH domains: 3.40.430.10 3.30.572.10
Bound ligands:   Het Group MTX is 91.18% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
3clb
Structure of bifunctional tcdhfr-ts in complex with tmq
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: y. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (510 residues) CATH domains: 3.40.430.10 3.30.572.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3d80
Structural analysis of a holo enzyme complex of mouse dihydr reductase with NADPH and a ternary complex wtih the potent selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]aze methylpteridine
Source: Mus musculus. Mouse. Organism_taxid: 10090. Strain: jm105. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group Q22 is 45.24% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
3d84
Structural analysis of a holo enzyme complex of mouse dihydr reductase with NADPH and a ternary complex with the potent selective inhibitor 2.4-diamino-6-(-2'-hydroxydibenz[b,f]az yl)methylpteridine
Source: Mus musculus. Mouse. Organism_taxid: 10090. Strain: jm105. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3dat
Crystal structure of the ternary mtx NADPH complex of bacill anthracis dihydrofolate reductase
Source: Bacillus anthracis str.. Organism_taxid: 260799. Strain: sterne. Gene: dfra, bas2083, ba_2237, gbaa2237. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (161 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.18% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
3dau
Crystal structure of the ternary mtx NADPH complex of escher dihydrofolate reductase
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: fola, tmra, b0048, jw0047. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.18% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
3dfr
Crystal structures of escherichia coli and lactobacillus casei dihydrofolate reductase refined at 1.7 angstroms resolution. I. General features and binding of methotrexate
Source: Lactobacillus casei. Organism_taxid: 1582
Chain: A (162 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
3dg8
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with rjf670, NADPH, and dump
Source: Plasmodium falciparum. Organism_taxid: 5833. Strain: v1/s. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (221 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3dga
Wild-type plasmodium falciparum dihydrofolate reductase- thymidylate synthase (pfdhfr-ts) complexed with rjf01302, NADPH, and dump
Source: Plasmodium falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (219 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3drc
Investigation of the functional role of tryptophan-22 in escherichia coli dihydrofolate reductase by site-directed mutagenesis
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
3e0b
Bacillus anthracis dihydrofolate reductase complexed with na 4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyr (ucp120b)
Source: Bacillus anthracis. Organism_taxid: 1392. Gene: dfra, bas2083, ba_2237, gbaa2237. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (166 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3eig
Crystal structure of a methotrexate-resistant mutant of huma dihydrofolate reductase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group MTX is 91.18% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
3f0b
Staphylococcus aureus dihydrofolate reductase complexed with 2,4-diamino-5-[3-(3-methoxy-5-phenylphenyl)but-1-ynyl]-6- methylpyrimidine
Source: Staphylococcus aureus rf122. Organism_taxid: 273036. Gene: dfrb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3f0q
Staphylococcus aureus dihydrofolate reductase complexed with 2,4-diamino-5-[3-(3-methoxy-5-(2,6-dimethylphenyl)phenyl)bu 6-methylpyrimidine
Source: Staphylococcus aureus rf122. Organism_taxid: 273036. Gene: dfrb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3f0s
Staphylococcus aureus dihydrofolate reductase complexed with 2,4-diamino-5-[3-(3-methoxy-5-(3,5-dimethylphenyl)phenyl)bu 6-methylpyrimidine
Source: Staphylococcus aureus rf122. Organism_taxid: 273036. Gene: dfrb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3f0u
Staphylococcus aureus f98y mutant dihydrofolate reductase co with NADPH and 2,4-diamino-5-[3-(3-methoxy-5-phenylphenyl)b ynyl]-6-methylpyrimidine
Source: Staphylococcus aureus rf122. Organism_taxid: 273036. Gene: dfrb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3f0v
Staphylococcus aureus f98y mutant dihydrofolate reductase co with NADPH and 2,4-diamino-5-[3-(3-methoxy-5-(2,6-dimethylp phenyl)but-1-ynyl]-6-methylpyrimidine
Source: Staphylococcus aureus rf122. Organism_taxid: 273036. Gene: dfrb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3f0x
Staphylococcus aureus f98y mutant dihydrofolate reductase co with NADPH and 2,4-diamino-5-[3-(3-methoxy-5-(3,5-dimethylp phenyl)but-1-ynyl]-6-methylpyrimidine
Source: Staphylococcus aureus rf122. Organism_taxid: 273036. Gene: dfrb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3f8y
Correlations of human dihydrofolate reductase with structura human active site mutant enzyme complexes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3f8z
Human dihydrofolate reductase structural data with active si enzyme complexes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3f91
Structural data for human active site mutant enzyme complexe
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3fl8
Crystal structure of b. Anthracis dihydrofolate reductase (dhfr) with rab1, a tmp-dihydrophthalazine derivative
Source: Bacillus anthracis. Anthrax. Organism_taxid: 1392. Strain: sterne. Gene: bas2083, ba_2237, dfra, dhfr, gbaa2237. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (166 residues) CATH domain: 3.40.430.10
3fl9
Crystal structure of b. Anthracis dihydrofolate reductase (d trimethoprim
Source: Bacillus anthracis. Organism_taxid: 1392. Strain: sterne. Gene: bas2083, ba_2237, dfra, dhfr, gbaa2237. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (164 residues) CATH domain: 3.40.430.10
3fq0
Staphylococcus aureus dihydrofolate reductase complexed with 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylp (ucp120b)
Source: Staphylococcus aureus rf122. Organism_taxid: 273036. Strain: rf122 / et3-1. Gene: dfrb, sab1281c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3fqc
Staphylococcus aureus dihydrofolate reductase complexed with 2,4-diamino-5-[3-(3,4,5-trimethoxyphenyl)pent-1-ynyl]-6- methylpyrimidine (ucp115a)
Source: Staphylococcus aureus rf122. Organism_taxid: 273036. Strain: rf122 / et3-1. Gene: dfrb, sab1281c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3fqf
Staphylococcus aureus f98y mutant dihydrofolate reductase co with NADPH and 2,4-diamino-5-[3-(3,4,5-trimethoxyphenyl)pen 6-methylpyrimidine (ucp115a)
Source: Staphylococcus aureus rf122. Organism_taxid: 273036. Strain: rf122 / et3-1. Gene: dfrb, sab1281c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3fqo
Staphylococcus aureus f98y mutant dihydrofolate reductase co with NADPH and 2,4-diamino-5-[3-(2,5-dimethoxyphenyl)prop-1 ethylpyrimidine (ucp120b)
Source: Staphylococcus aureus rf122. Organism_taxid: 273036. Strain: rf122 / et3-1. Gene: dfrb, sab1281c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3fqv
Staphylococcus aureus f98y mutant dihydrofolate reductase co with NADPH and 2,4-diamino-5-[3-(3-methoxy-4-phenylphenyl)b ynyl]-6-methylpyrimidine
Source: Staphylococcus aureus rf122. Organism_taxid: 273036. Strain: rf122 / et3-1. Gene: dfrb, sab1281c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3fqz
Staphylococcus aureus dihydrofolate reductase complexed with 2,4-diamino-5-[3-(3-methoxy-4-phenylphenyl)but-1-ynyl]-6- methylpyrimidine
Source: Staphylococcus aureus rf122. Organism_taxid: 273036. Strain: rf122 / et3-1. Gene: dfrb, sab1281c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3fra
Staphylococcus aureus f98y dhfr complexed with iclaprim
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3frb
S. Aureus f98y dhfr complexed with tmp
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3frd
S. Aureus dhfr complexed with NADPH and folate
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group DHF corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
3fre
S. Aureus dhfr complexed with NADPH and tmp
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3frf
S. Aureus dhfr complexed with NADPH and iclaprim
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: X (158 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3fs6
Correlations of inhibitor kinetics for pneumocystis jiroveci human dihydrofolate reductase with structural data for huma site mutant enzyme complexes
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pds5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3fy8
Crystal structure of staph. Aureus dhfr complexed with NADPH 101
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3fy9
Staph. Aureus dhfr f98y complexed with ar-102
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3fyv
Staph. Aureus dhfr complexed with NADPH and ar-102
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: X (158 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3fyw
Staph. Aureus dhfr complexed with NADPH and ar-101
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: X (158 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3ghc
Design, synthesis, and x-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-thieno[2,3- d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agenst
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3ghv
Human dihydrofolate reductase q35k/n64f double mutant inhibi complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3ghw
Human dihydrofolate reductase inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group GHW is 40.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
3gi2
Human dihydrofolate reductase q35k mutant inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group GHW is 40.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
3gyf
Human dhfr with z-isomer in orthorhombic lattice
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3hbb
Structures of dihydrofolate reductase-thymidylate synthase o trypanosoma cruzi in the folate-free state and in complex w antifolate drugs, trimetrexate and methotrexate
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: y. Gene: dhfr-ts. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (510 residues) CATH domains: 3.40.430.10 3.30.572.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3i8a
Staphylococcus aureus h30n, f98y dihydrofolate reductase com with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1 ethylpyrimidine (ucp120b)
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: dfrb, fola. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3ia4
Moritella profunda dihydrofolate reductase (dhfr) in complex with NADPH and methotrexate (mtx)
Source: Moritella profunda. Organism_taxid: 111291. Gene: dyra. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (161 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
3ia5
Moritella profunda dihydrofolate reductase (dhfr)
Source: Moritella profunda. Organism_taxid: 111291. Gene: dyra. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (159 residues) CATH domain: 3.40.430.10
3inv
Trypanosoma cruzi dihydrofolate reductase-thymidylate syntha complexed with NADPH, dump and c-448 antifolate
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: y. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (514 residues) CATH domains: 3.40.430.10 3.30.572.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3irm
Trypanosoma cruzi dihydrofolate reductase-thymidylate syntha complexed with cycloguanil
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: y. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (520 residues) CATH domains: 3.40.430.10 3.30.572.10
3irn
Trypanosoma cruzi dihydrofolate reductase-thymidylate syntha complexed with NADPH and cycloguanil
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: y. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (516 residues) CATH domains: 3.40.430.10 3.30.572.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3iro
Trypanosoma cruzi dihydrofolate reductase-thymidylate syntha complexed with NADPH and q-8 antifolate
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: y. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (518 residues) CATH domains: 3.40.430.10 3.30.572.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3ix9
Crystal structure of streptococcus pneumoniae dihydrofolate reductase - sp9 mutant
Source: Streptococcus pneumoniae. Organism_taxid: 1313. Gene: dfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (166 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
3jvx
Crystal structure of bacillus anthracis dihydrofolate reduct complexed with NADPH and 2,4-diamino-5-(3-(3,4,5-trimethoxy prop-1-ynyl)-6-ethylpyrimidine (ucp120a)
Source: Bacillus anthracis. Organism_taxid: 1392. Gene: bas2083, ba_2237, dfra, gbaa2237, gbaa_2237. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (166 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3jw3
Crystal structure of bacillus anthracis (f96i) dihydrofolate complexed with NADPH and trimethoprim
Source: Bacillus anthracis. Organism_taxid: 1392. Gene: bas2083, bas2084, ba_2237, dfra, gbaa2237, gbaa_2237. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (165 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3jw5
Crystal structure of bacillus anthracis (y102f) dihydrofolat reductase complexed with NADPH and trimethoprim
Source: Bacillus anthracis. Organism_taxid: 1392. Gene: bas2083, ba_2237, dfra, gbaa2237, gbaa_2237. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (165 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3jwc
Crystal structure of bacillus anthracis (y102f) dihydrofolat reductase complexed with NADPH and 2,4-diamino-5-(3-(3,4,5- trimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (ucp120a)
Source: Bacillus anthracis. Organism_taxid: 1392. Gene: bas2083, ba_2237, dfra, gbaa2237, gbaa_2237. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (165 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3jwf
Crystal structure of bacillus anthracis (y102f) dihydrofolat reductase complexed with NADPH and (r)-2,4-diamino-5-(3-hyd 4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (ucp11
Source: Bacillus anthracis. Organism_taxid: 1392. Gene: bas2083, ba_2237, dfra, gbaa2237, gbaa_2237. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (165 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3jwk
Crystal structure of bacillus anthracis (y102f) dihydrofolat reductase complexed with NADPH and (s)-2,4-diamino-5-(3-met 4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (ucp11
Source: Bacillus anthracis. Organism_taxid: 1392. Gene: bas2083, ba_2237, dfra, gbaa2237, gbaa_2237. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (165 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3jwm
Crystal structure of bacillus anthracis dihydrofolate reduct complexed with NADPH and (s)-2,4-diamino-5-(3-methoxy-3-(3, trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (ucp114a)
Source: Bacillus anthracis. Organism_taxid: 1392. Gene: bas2083, ba_2237, dfra, gbaa2237, gbaa_2237. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (165 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3k45
Alternate binding modes observed for the e- and z-isomers of diaminofuro[2,3d]pyrimidines as ternary complexes with NADP mouse dihydrofolate reductase
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3k47
Alternate binding modes observed for the e- and z-isomers of diaminofuro[2,3-d]pyrimidines as ternary complexes with NAD mouse dihydrofolate reductase
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3k74
Disruption of protein dynamics by an allosteric effector ant
Source: Escherichia coli k-12. Organism_taxid: 83333. Strain: rt500. Gene: b0048, dhfr, fola, jw0047, tmra. Expressed in: escherichia coli. Expression_system_taxid: 562. Lama glama. Organism_taxid: 9844. Gene: lama.
Chain: A (159 residues) CATH domain: 3.40.430.10
3kfy
Dynamic switching and partial occupancies of a small molecul inhibitor complex of dhfr
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP is 64.00% similar to enzyme reactant NADP(+)
3l3r
Structural, computational and kinetic data for antifolate in against pneumocystis jirovecii, pneumocystis carinii and hu dihydrofolate reductase and their active site mutants
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group OAG is 50.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
3lg4
Staphylococcus aureus v31y, f92i mutant dihydrofolate reduct complexed with NADPH and 5-[(3s)-3-(5-methoxy-2',6'-dimethy 3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: dfra, dfrb, fola. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3m08
Wild type dihydrofolate reductase from staphylococcus aureus inhibitor rab1
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (161 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3m09
F98y tmp-resistant dihydrofolate reductase from staphylococc with inhibitor rab1
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (161 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3n0h
Hdhfr double mutant q35s/n64f trimethoprim binary complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1, pds5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
3ntz
Design, synthesis, biological evaluation and x-ray crystal s of novel classical 6,5,6-tricyclicbenzo[4,5]thieno[2,3-d]py as dual thymidylate synthase and dihydrofolate reductase in
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group 3TZ is 48.89% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
3nu0
Design, synthesis, biological evaluation and x-ray crystal s of novel classical 6,5,6-tricyclicbenzo[4,5]thieno[2,3-d]py as dual thymidylate synthase and dihydrofolate reductase in
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group 3TU is 47.83% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
3nxo
Perferential selection of isomer binding from chiral mixture alternate binding modes observed for the e- and z-isomers o of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as terna complexes with NADPH and human dihydrofolate reductase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3nxr
Perferential selection of isomer binding from chiral mixture alternate binding modes observed for the e- and z-isomers o of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as terna complexes with NADPH and human dihydrofolate reductase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3nxt
Preferential selection of isomer binding from chiral mixture alternate binding modes observed for the e-and z-isomers of of 5-substituted 2,4-diaminofuro[2m,3-d]pyrimidines as tern complexes with NADPH and human dihydrofolate reductase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3nxv
Preferential selection of isomer binding from chiral mixture alternate binding modes observed for the e- and z-isomers o of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as terna complexes with NADPH and human dihydrofolate reductase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3nxx
Preferential selection of isomer binding from chiral mixture alternate binding modes observed for the e- and z-isomers o of 5-substituted 2,4-diaminofuro-2,3-d]pyrimidines as terna complexes with NADPH and human dihydrofolate reductase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3nxy
Preferential selection of isomer binding from chiral mixture alernate binding modes observed fro the e- and z-isomers of of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as terna complexes with NADPH and human dihydrofolate reductase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3nz6
Structural analysis of pneumocystis carinii and human dhfr c with NADPH and a series of five potent 5-(omega-carboxy(alk pyrido[2,3-d]pyrimidine derivatives
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (206 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3nz9
Structural analysis of pneumocystis carinii and human dhfr c with NADPH and a series of five potent 5-(omega-carboxy(alk pyrido[2,3-d]pyrimidine derivatives
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (206 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3nza
Structural analysis of pneumocystis carinii and human dhfr c with NADPH and a series of five potent 5-(omega-carboxy(alk pyrido[2,3-d]pyrimidine derivatives
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (206 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3nzb
Structural analysis of pneumocystis carinii and human dhfr c with NADPH and a series of potent 5-(omega-carboxyl(alkylox pyrido[2,-d]pyrimidine derivatives
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (206 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3nzc
Structural analysis of pneumocystis carinii and human dhfr c with NADPH and a series of five potent 5-(omega-carboxy(alk pyrido[2,3-d]pyridine derivativea
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (206 residues) CATH domain: 3.40.430.10
3nzd
Structural analysis of pneumocystis carinii and human dhfr c with NADPH and a series of five 5-(omega-carboxy(alkyloxy(p d]pyrimidine derivatives
Source: Homo sapiens. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3oaf
Structural and kinetic data for antifolate interactions agai pneumocystis jirovecii, pneumocystis carinii and human dihy reductase and thier active site mutants
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, dhfrp1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group OAG is 50.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
3och
Chemically self-assembled antibody nanorings (csans): design characterization of an anti-cd3 igm biomimetic
Source: Escherichia coli. Organism_taxid: 83333. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (159 residues) CATH domain: 3.40.430.10
3q1h
Crystal structure of dihydrofolate reductase from yersinia p
Source: Yersinia pestis. Organism_taxid: 214092. Strain: co92. Gene: fola, y3688, ypo0486, yp_3693. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (161 residues) CATH domain: 3.40.430.10
3qfx
Trypanosoma brucei dihydrofolate reductase pyrimethamine com
Source: Trypanosoma brucei rhodesiense. Organism_taxid: 31286. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (219 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3ql0
Crystal structure of n23pp/s148a mutant of e. Coli dihydrofo reductase
Source: Escherichia coli. Organism_taxid: 364106. Strain: uti89 / upec. Gene: fola, uti89_c0054. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (160 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
3ql3
Re-refined coordinates for PDB entry 1rx2
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: fola, tmra, b0048, jw0047. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
3qlr
Candida albicans dihydrofolate reductase complexed with NADP methyl-5-[(3r)-3-(3,4,5-trimethoxyphenyl)pent-1-yn-1-yl]pyr 4-diamine (ucp112a)
Source: Candida albicans. Yeast. Organism_taxid: 5476. Gene: caj7.0360, cao19.12607, cao19.5142, dfr1, dhfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (192 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3qls
Candida albicans dihydrofolate reductase complexed with NADP methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1- yl]pyrimidine-2,4-diamine (ucp115a)
Source: Candida albicans. Yeast. Organism_taxid: 5476. Gene: caj7.0360, cao19.12607, cao19.5142, dfr1, dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (192 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3qlw
Candida albicans dihydrofolate reductase complexed with NADP [3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2 (ucp120b)
Source: Candida albicans. Yeast. Organism_taxid: 5476. Gene: caj7.0360, cao19.12607, cao19.5142, dfr1, dhfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (190 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3qyl
Sensitivity of receptor internal motions to ligand binding a and kinetic off-rate
Source: Escherichia coli k-12. Organism_taxid: 83333. Strain: k12
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3qyo
Sensitivity of receptor internal motions to ligand binding a and kinetic off-rate
Source: Escherichia coli k-12. Organism_taxid: 83333. Strain: k12
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3r33
Evidence for dynamic motion in proteins as a mechanism for l dissociation
Source: Escherichia coli k-12. Organism_taxid: 83333. Strain: k12
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3rg9
Trypanosoma brucei dihydrofolate reductase (tbdhfr) in compl wr99210
Source: Trypanosoma brucei rhodesiense. Organism_taxid: 31286. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (218 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3s3v
Human dihydrofolate reductase q35k/n64f double mutant binary with trimethoprim
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, pds5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
3s7a
Human dihydrofolate reductase binary complex with pt684
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group 684 is 42.55% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
3s9u
Bacillus anthracis dihydrofolate reductase bound to propargy tmp analog, ucp120j
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 1392. Gene: bas2083, ba_2237, dfra, gbaa2237, gbaa_2237. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (165 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3sa1
Bacuills anthracis dihydrofolate reductase bound propargyl-l analog, ucp1021
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 1392. Gene: bas2083, ba_2237, dfra, gbaa2237, gbaa_2237. Expressed in: escherichia coli. Expression_system_taxid: 1007065.
Chains: A, B (164 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3sa2
Bacuills anthracis dihydrofolate reductase bound propargyl-l analog, ucp1014
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 1392. Gene: bas2083, ba_2237, dfra, gbaa2237, gbaa_2237. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (165 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3sai
Bacuills anthracis dihydrofolate reductase bound to propargy tmp analog, ucp1015
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 1392. Gene: bas2083, ba_2237, dfra, gbaa2237, gbaa_2237. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (165 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3sfm
Novel crystallization conditions for tandem variant r67 dhfr wild-type crystal structure
Source: Escherichia coli. Organism_taxid: 562. Gene: dfrb. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (58 residues) CATH domain: 2.30.30.60
3sgy
Staphylococcus aureus dihydrofolate reductase complexed with 6-ethyl-5-[(3s)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-y yl]pyrimidine-2,4-diamine (ucp1006)
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: dfra, dfrb, fola. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3sh2
Staphylococcus aureus dihydrofolate reductase complexed with 6-ethyl-5-(3-(4-methoxybiphenyl-3-yl)prop-1-ynyl)pyrimidine diamine (ucp120j)
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: dfra, dfrb, fola. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3sqy
S. Aureus dihydrofolate reductase complexed with novel 7-ary diaminoquinazolines
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3sr5
S. Aureus dihydrofolate reductase complexed with novel 7-ary diaminoquinazolines
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3srq
S. Aureus dihydrofolate reductase complexed with novel 7-ary diaminoquinazolines
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3srr
S. Aureus dihydrofolate reductase complexed with novel 7-ary diaminoquinazolines
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3srs
S. Aureus dihydrofolate reductase complexed with novel 7-ary diaminoquinazolines
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3sru
S. Aureus dihydrofolate reductase complexed with novel 7-ary diaminoquinazolines
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3srw
S. Aureus dihydrofolate reductase complexed with novel 7-ary diaminoquinazolines
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3td8
Structural analysis of pneumocystis carinii dihydrofolate re complex with NADPH and 2,4-diamino-5-methyl-6-[2'-(4-carbox pentynyl)-5'-methoxybenzyl]pyrido[2,3-d]pyrimidine
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (194 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3tq8
Structure of the dihydrofolate reductase (fola) from coxiell in complex with trimethoprim
Source: Coxiella burnetii. Organism_taxid: 777. Strain: rsa 493 nine mile phase i. Gene: cbu_1993, fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (171 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3tq9
Structure of the dihydrofolate reductase (fola) from coxiell in complex with methotrexate
Source: Coxiella burnetii. Organism_taxid: 777. Strain: rsa 493 nine mile phase i. Gene: cbu_1993, fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (151 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.18% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
3tqa
Structure of the dihydrofolate reductase (fola) from coxiell in complex with NADPH
Source: Coxiella burnetii. Organism_taxid: 777. Strain: rsa 493 nine mile phase i. Gene: cbu_1993, fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3tqb
Structure of the dihydrofolate reductase (fola) from coxiell in complex with folate
Source: Coxiella burnetii. Organism_taxid: 777. Strain: rsa 493 nine mile phase i. Gene: cbu_1993, fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (151 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
3vco
Schistosoma mansoni dihydrofolate reductase
Source: Schistosoma mansoni. Blood fluke. Organism_taxid: 6183. Gene: dhfr, smp_175230. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (183 residues) CATH domain: 3.40.430.10
4cd2
Ligand induced conformational changes in the crystal structures of pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (202 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
4ddr
Human dihydrofolate reductase complexed with NADPH and p218
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4dfr
Crystal structures of escherichia coli and lactobacillus cas dihydrofolate reductase refined at 1.7 angstroms resolution general features and binding of methotrexate
Source: Escherichia coli. Organism_taxid: 37762. Strain: b
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group MTX is 91.18% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
4eck
Crystal structure of the toxoplasma gondii ts-dhfr
Source: Toxoplasma gondii. Organism_taxid: 5811. Strain: k-12. Gene: drts. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (498 residues) CATH domains: 3.40.430.10 Unassigned 3.30.572.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
4eig
Ca1698 camel antibody fragment in complex with dhfr
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: fola, tmra, b0048, jw0047. Expressed in: escherichia coli. Expression_system_taxid: 562. Lama glama. Organism_taxid: 9844. Expression_system_taxid: 562
Chain: A (159 residues) CATH domain: 3.40.430.10
4eil
Crystal structure of the loop truncated toxoplasma gondii ts
Source: Toxoplasma gondii. Organism_taxid: 5811. Strain: k-12. Gene: drts. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (510 residues) CATH domains: 3.40.430.10 Unassigned 3.30.572.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
4eiz
Structure of nb113 bound to apodhfr
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: fola, tmra, b0048, jw0047. Expressed in: escherichia coli. Expression_system_taxid: 562. Lama glama. Organism_taxid: 9844. Expression_system_taxid: 562
Chains: A, B (159 residues) CATH domain: 3.40.430.10
4ej1
Binding of nb113 camelid antibody fragment with the binary d complex
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: fola, tmra, b0048, jw0047. Expressed in: escherichia coli. Expression_system_taxid: 562. Lama glama. Organism_taxid: 9844. Expression_system_taxid: 562
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group FOL is 90.62% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
4elb
Structure-activity relationship guides enantiomeric preferen potent inhibitors of b. Anthracis dihydrofolate reductase
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 260799. Strain: sterne. Gene: bas2083, ba_2237, dfra, dhfr, gbaa_2237. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, H, C, B, G, F, D, E (166 residues) CATH domain: 3.40.430.10
4ele
Structure-activity relationship guides enantiomeric preferen potent inhibitors of b. Anthracis dihydrofolate reductase
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 260799. Strain: sterne. Gene: bas2083, ba_2237, dfra, dhfr, gbaa_2237. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (166 residues) CATH domain: 3.40.430.10
4elf
Structure-activity relationship guides enantiomeric preferen potent inhibitors of b. Anthracis dihydrofolate reductase
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 260799. Strain: sterne. Gene: bas2083, ba_2237, dfra, dhfr, gbaa_2237. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (166 residues) CATH domain: 3.40.430.10
4elg
Structure-activity relationship guides enantiomeric preferen potent inhibitors of b. Anthracis dihydrofolate reductase
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 260799. Strain: sterne. Gene: bas2083, ba_2237, dfra, dhfr, gbaa_2237. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (166 residues) CATH domain: 3.40.430.10
4elh
Structure-activity relationship guides enantiomeric preferen potent inhibitors of b. Anthracis dihydrofolate reductase
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 260799. Strain: sterne. Gene: bas2083, ba_2237, dfra, dhfr, gbaa_2237. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, H, C, B, G, F, D, E (166 residues) CATH domain: 3.40.430.10
4fgg
S. Aureus dihydrofolate reductase co-crystallized with propy isobutenyl-dihydrophthalazine inhibitor
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: dhfr, fola. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (163 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
4fgh
S. Aureus dihydrofolate reductase co-crystallized with ethyl isobutenyl-dihydrophthalazine inhibitor
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: dhfr, fola. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (163 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
4fhb
Enhancing dhfr catalysis by binding of an allosteric regulat nanobody (nb179)
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: fola, tmra, b0048, jw0047. Expressed in: escherichia coli. Expression_system_taxid: 562. Lama glama. Organism_taxid: 9844. Expression_system_taxid: 562
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4g8z
Pcdhfr k37s/f69n double mutant tmp NADPH ternary complex
Source: Pneumocystis jirovecii. Organism_taxid: 42068. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: X (204 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4g95
Hdhfr-oag binary complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group OAG is 50.00% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
4gh8
Crystal structure of a 'humanized' e. Coli dihydrofolate red
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: fola, tmra, b0048, jw0047. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: B, A (162 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.18% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
4h95
Candida albicans dihydrofolate reductase complexed with NADP ethyl-5-{3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1- yl}pyrimidine-2,4-diamine (ucp1006)
Source: Candida albicans. Yeast. Organism_taxid: 5476. Gene: dfr1, dhfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (189 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4h96
Candida albicans dihydrofolate reductase complexed with NADP {3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]pr yl}-6-ethylpyrimidine-2,4-diamine (ucp1018)
Source: Candida albicans. Organism_taxid: 5476. Gene: dfr1, dhfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (189 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4h97
Candida albicans dihydrofolate reductase complexed with NADP {3-[3-methoxy-5-(4-methylphenyl)phenyl]but-1-yn-1-yl}-6- methylpyrimidine-2,4-diamine (ucp111d4m)
Source: Candida albicans. Organism_taxid: 5476. Gene: dfr1, dhfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (190 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4hoe
Candida albicans dihydrofolate reductase complexed with NADP [3-(2,5-dimethoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyr 4-diamine (ucp111e)
Source: Candida albicans. Yeast. Organism_taxid: 5476. Gene: dfr1, dhfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (192 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4hof
Candida albicans dihydrofolate reductase complexed with NADP [3-(2-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimid diamine (ucp111h)
Source: Candida albicans. Yeast. Organism_taxid: 5476. Gene: dfr1, dhfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (192 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4i13
Nanobody ca1697 binding to the dhfr.Folate binary complex
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: fola, tmra, b0048, jw0047. Expressed in: escherichia coli. Expression_system_taxid: 562. Lama glama. Organism_taxid: 9844.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
4i1n
R104a-ca1697 nanobody binding to the binary dhfr.Folate comp
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: fola, tmra, b0048, jw0047. Expressed in: escherichia coli. Expression_system_taxid: 562. Lama glama. Organism_taxid: 9844.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
4ixe
Pcdhfr-NADPH-270
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: D (206 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4ixf
Pcdhfr-269 f69n variant
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (206 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4ixg
Pcdhfr-268-k37s-n69f variant
Source: Pneumocystis carinii. Organism_taxid: 4754. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (206 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4kak
Crystal structure of human dihydrofolate reductase complexed NADPH and 6-ethyl-5-[(3s)-3-[3-methoxy-5-(pyridine-4-yl)phe yn-1-yl]pyrimidine-2,4-diamine (ucp1006)
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: rp11-399l5. Gene: dhfr, hudhfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4kbn
Human dihydrofolate reductase complexed with NADPH and 5-{3- pyrimidine)]-phenyl-prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4d
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, hudhfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4kd7
Human dihydrofolate reductase complexed with NADPH and 5-{3- methoxy-5(pyridine-4-yl)phenyl]prop-1-yn-1-yl}-6-ethyl-pyri 4-diamine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, hudhfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4keb
Human dihydrofolate reductase complexed with NADPH and 5-{3- methoxy-5-(isoquin-5-yl)phenyl]but-1-yn-1-yl}6-ethylpyrimid diamine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, hudhfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
4kfj
Human dihydrofolate reductase complexed with NADPH and 5-{3- methoxy-5-(isoquin-5-yl)phenyl]prop-1-yn-1-yl}6-ethylprimid diamine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr, hudhfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NDP corresponds to enzyme reactant NADP(+)
4kjj
Cryogenic wt dhfr
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: fola, uti89_c0054. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4kjk
Room temperature wt dhfr
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: fola, uti89_c0054. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4kjl
Room temperature n23pps148a dhfr
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: fola, uti89_c0054. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (160 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4kl9
Crystal structure of dihydrofolate reductase from mycobacter tuberculosis in the space group c2
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: dfra, fola, mt2833, mtv002.28c, rv2763c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (160 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4klx
Crystal structure of dihydrofolate reductase from mycobacter tuberculosis in an open conformation.
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: dfra, fola, h37rv, mt2833, mtv002.28c, rv2763c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (161 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group ATR is 64.58% similar to enzyme reactant NADP(+)
4km0
Crystal structure of dihydrofolate reductase from mycobacter tuberculosis in complex with pyrimethamine
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: dfra, fola, mt2833, mtv002.28c, rv2763c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (161 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group ATR is 64.58% similar to enzyme reactant NADP(+)
4km2
Crystal structure of dihydrofolate reductase from mycobacter tuberculosis in an open conformation in complex with trimet
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: dfra, fola, mt2833, mtv002.28c, rv2763c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group ATR is 64.58% similar to enzyme reactant NADP(+)
4kne
Crystal structure of dihydrofolate reductase from mycobacter tuberculosis in complex with cycloguanil
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: dfra, fola, mt2833, mtv002.28c, rv2763c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (159 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group ATR is 64.58% similar to enzyme reactant NADP(+)
4lae
Structure-based design of new dihydrofolate reductase antiba agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group 1VM is 42.86% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4lag
Structure-based design of new dihydrofolate reductase antiba agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group 1VN is 41.86% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4lah
Structure-based design of new dihydrofolate reductase antiba agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group 1VO is 42.86% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4lek
Structure-based design of new dihydrofolate reductase antiba agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: fola. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: X (157 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group 1DN is 40.91% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4m6j
Crystal structure of human dihydrofolate reductase (dhfr) bo NADPH
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (184 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4m6k
Crystal structure of human dihydrofolate reductase (dhfr) bo NADP+ and folate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4m6l
Crystal structure of human dihydrofolate reductase (dhfr) bo NADP+ and 5,10-dideazatetrahydrofolic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
4m7u
Dihydrofolate reductase from enterococcus faecalis complexed NADP(h)
Source: Enterococcus faecalis. Organism_taxid: 226185. Strain: 700802. Gene: dihydrofolate reductase, ef_1577, fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (170 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
4m7v
Dihydrofolate reductase from enterococcus faecalis complexed NADP(h)and rab-propyl
Source: Enterococcus faecalis. Organism_taxid: 226185. Strain: 700802. Gene: dihydrofolate reductase, ef_1577, fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (168 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
4nx6
Single room temperature model of dhfr
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: fola, tmra. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4nx7
Single cryogenic temperature model of dhfr
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: fola, tmra. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4p3q
Room-temperature wt dhfr, time-averaged ensemble
Source: Escherichia coli. Organism_taxid: 316385. Strain: k12 / dh10b. Gene: fola, ecdh10b_0049. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4p3r
Cryogenic wt dhfr, time-averaged ensemble
Source: Escherichia coli. Organism_taxid: 316385. Strain: k12 / dh10b. Gene: fola, ecdh10b_0049. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4p66
Electrostatics of active site microenvironments of e. Coli d
Source: Escherichia coli. Organism_taxid: 562. Gene: fola, ecs0051, lf82_0721. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.18% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4p68
Electrostatics of active site microenvironments for e. Coli
Source: Escherichia coli. Organism_taxid: 562. Gene: fola, ecs0051, lf82_0721. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group MTX is 91.18% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4pss
Multiconformer model for escherichia coli dihydrofolate redu 100k
Source: Escherichia coli. Organism_taxid: 1403831. Gene: bn896_0046, fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
4pst
Multiconformer model for escherichia coli dihydrofolate redu 277 k
Source: Escherichia coli. Organism_taxid: 1403831. Gene: bn896_0046, fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
4psy
100k crystal structure of escherichia coli dihydrofolate red
Source: Escherichia coli. Organism_taxid: 1403831. Gene: bn896_0046, fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4psz
277k crystal structure of escherichia coli dihydrofolate red
Source: Escherichia coli. Organism_taxid: 1403831. Gene: bn896_0046, fola. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4pth
Ensemble model for escherichia coli dihydrofolate reductase
Source: Escherichia coli. Organism_taxid: 316385. Strain: k12 / dh10b. Gene: fola, ecdh10b_0049. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4ptj
Ensemble model for escherichia coli dihydrofolate reductase
Source: Escherichia coli. Organism_taxid: 316385. Strain: k12 / dh10b. Gene: fola, ecdh10b_0049. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
4qi9
Crystal structure of dihydrofolate reductase from yersinia p complexed with methotrexate
Source: Yersinia pestis. Organism_taxid: 214092. Strain: co92. Gene: fola, y3688, ypo0486, yp_3693. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C (158 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group MTX is 91.18% similar to enzyme reactant 5,6,7,8-tetrahydrofolate
5dfr
Crystal structure of unliganded escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding
Source: Escherichia coli. Organism_taxid: 562.
Chain: A (154 residues) CATH domain: 3.40.430.10
6dfr
Crystal structures of escherichia coli dihydrofolate reductase. The NADP+ holoenzyme and the folate(dot)NADP+ ternary complex. Substrate binding and a model for the transition state
Source: Escherichia coli. Organism_taxid: 562.
Chain: A (154 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NAP is 75.00% similar to enzyme reactant NADP(+)
7dfr
Crystal structures of escherichia coli dihydrofolate reductase. The NADP+ holoenzyme and the folate(dot)NADP+ ternary complex. Substrate binding and a model for the transition state
Source: Escherichia coli. Organism_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.430.10
Bound ligands:   Het Group FOL corresponds to enzyme reactant 5,6,7,8-tetrahydrofolate
  Het Group NAP corresponds to enzyme reactant NADP(+)
8dfr
Refined crystal structures of chicken liver dihydrofolate reductase. 3 angstroms apo-enzyme and 1.7 angstroms NADPH holo-enzyme complex
Source: Gallus gallus. Chicken. Organism_taxid: 9031
Chain: A (186 residues) CATH domain: 3.40.430.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)