PDBsum entry 5o2c

Structural genomics

PDB id: 5o2c

Contents

Protein chain

368 a.a.

Ligands

PEG

GOL ×4

Waters ×117

PDB id:

5o2c

Name:

Structural genomics

Title:

Crystal structure of wnk3 kinase and cct1 didomain in a unphosphorylated state

Structure:

Serine/threonine-protein kinase wnk3. Chain: a. Fragment: unp residues 123-500. Synonym: protein kinase lysine-deficient 3,protein kinase with no lysine 3. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: wnk3, kiaa1566, prkwnk3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.40Å R-factor: 0.189 R-free: 0.254

Authors:

S.G.Bartual,D.M.Pinkas,J.C.Bufton,K.Kupinska,D.Wang,R.Chalk, G.Berridge,N.A.Burgess-Brown,F.Von Delft,C.H.Arrowsmith,A.M.Edwards, C.Bountra,A.Bullock,Structural Genomics Consortium (Sgc)

Key ref:

D.M.Pinkas et al. Crystal structure of wnk3 kinase and cct1 didomain in unphosphorylated state. To be published, .

Date:

19-May-17 Release date: 28-Jun-17

Protein chain

Q9BYP7  (WNK3_HUMAN) -  Serine/threonine-protein kinase WNK3 from Homo sapiens

Seq: 1800 a.a.

Struc: 368 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site