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PDBsum entry 5a2m

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protein ligands metals Protein-protein interface(s) links
Hydrolase PDB id
5a2m

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
251 a.a.
29 a.a.
Ligands
ASP-PHE-GLU-GLU-
ILE-PRO-GLU-GLU-
TYS-LEU
GOL
WX5
NAG
Metals
_NA ×2
Waters ×234
PDB id:
5a2m
Name: Hydrolase
Title: Thrombin inhibitor
Structure: Thrombin heavy chain. Chain: h. Fragment: thrombin heavy chain, unp residues 364-621. Synonym: prothrombin, coagulation factor ii, activation peptide fragment 1, activation peptide fragment 2, thrombin light chain, thrombin heavy chain. Hirudin variant-2. Chain: i. Fragment: unp residues 61-72.
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purified from human blood plasma. Synthetic: yes. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Other_details: purified from human blood plasma
Resolution:
1.40Å     R-factor:   0.138     R-free:   0.159
Authors: E.Ruehmann,A.Heine,G.Klebe
Key ref: E.Ruehmann et al. Thrombin inhibition. To be published, .
Date:
20-May-15     Release date:   01-Jun-16    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00734  (THRB_HUMAN) -  Prothrombin from Homo sapiens
Seq:
Struc:
 
Seq:
Struc:
622 a.a.
251 a.a.
Protein chain
Pfam   ArchSchema ?
P00734  (THRB_HUMAN) -  Prothrombin from Homo sapiens
Seq:
Struc:
 
Seq:
Struc:
622 a.a.
29 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains H, L: E.C.3.4.21.5  - thrombin.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Preferential cleavage: Arg-|-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.

 

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