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PDBsum entry 2wns
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Transferase
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Title:
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Human orotate phosphoribosyltransferase (oprtase) domain of uridine 5' -monophosphate synthase (umps) in complex with its substrate orotidine 5'-monophosphate (omp)
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Structure:
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Orotate phosphoribosyltransferase. Chain: a, b. Fragment: oprtase domain, residues 7-203. Synonym: oprtase, uridine 5'-monophosphate synthase. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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1.90Å
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R-factor:
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0.182
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R-free:
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0.228
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Authors:
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M.Moche,A.Roos,C.H.Arrowsmith,H.Berglund,C.Bountra,R.Collins, A.M.Edwards,S.Flodin,A.Flores,S.Graslund,M.Hammarstrom,A.Johansson, I.Johansson,T.Karlberg,T.Kotyenova,A.Kotzch,T.K.Nielsen,T.Nyman, C.Persson,J.Sagemark,H.Schueler,P.Schutz,M.I.Siponen,L.Svensson, A.G.Thorsell,L.Tresaugues,S.Vandenberg,J.Weigelt,M.Welin, M.Wisniewska,P.Nordlund
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Key ref:
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M.Moche
et al.
Human orotate phosphoribosyltransferase (oprtase) domain of uridine 5'-Monophosphate synthase (umps) in complex with its substrate orotidine 5'- Monophosphate (omp).
To be published,
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Date:
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19-Jul-09
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Release date:
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11-Aug-09
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PROCHECK
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Headers
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References
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P11172
(UMPS_HUMAN) -
Uridine 5'-monophosphate synthase from Homo sapiens
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Seq:
Struc:
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480 a.a.
197 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class 1:
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E.C.2.4.2.10
- orotate phosphoribosyltransferase.
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Pathway:
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Pyrimidine Biosynthesis
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Reaction:
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orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
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orotidine 5'-phosphate
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+
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diphosphate
Bound ligand (Het Group name = )
corresponds exactly
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=
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orotate
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+
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5-phospho-alpha-D-ribose 1-diphosphate
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Enzyme class 2:
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E.C.4.1.1.23
- orotidine-5'-phosphate decarboxylase.
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Pathway:
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Reaction:
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orotidine 5'-phosphate + H+ = UMP + CO2
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orotidine 5'-phosphate
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+
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H(+)
Bound ligand (Het Group name = )
corresponds exactly
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=
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UMP
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+
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CO2
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
