EC 4.1.1.23 - Orotidine-5'-phosphate decarboxylase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 4.1.1.23

Names

Accepted name:
orotidine-5'-phosphate decarboxylase
Other names:
ODCase
OMP decarboxylase
OMP-DC
orotate decarboxylase
orotate monophosphate decarboxylase
orotic decarboxylase
orotidine 5'-phosphate decarboxylase
orotidine monophosphate decarboxylase
orotidine phosphate decarboxylase
orotidine-5'-monophosphate decarboxylase
orotidylic acid decarboxylase
orotidylic decarboxylase
orotodylate decarboxylase
uridine 5'-monophosphate synthase
OMPdcase
UMP synthase
orotidine-5'-phosphate carboxy-lyase
Systematic name:
orotidine-5'-phosphate carboxy-lyase (UMP-forming)

Reaction

Comments:

The enzyme from higher eukaryotes is identical with EC 2.4.2.10 orotate phosphoribosyltransferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00141
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004590
CAS Registry Number: 9024-62-8
UniProtKB/Swiss-Prot: (580) [show] [UniProt]

References

  1. Jones, M.E., Kavipurapu, P.R. and Traut, T.W.
    Orotate phosphoribosyltransferase: orotidylate decarboxylase (Ehrlich ascites cell).
    Methods Enzymol. 51: 155-167 (1978). [PMID: 692383]
  2. Lieberman, I., Kornberg, A. and Simms, E.S.
    Enzymatic synthesis of pyrimidine nucleotides. Orotidine-5'-phosphate and uridine-5'-phosphate.
    J. Biol. Chem. 215: 403-415 (1955). [PMID: 14392174]
  3. McClard, R.W., Black, M.J., Livingstone, L.R. and Jones, M.E.
    Isolation and initial characterization of the single polypeptide that synthesizes uridine 5'-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5'-monophosphate synthase.
    Biochemistry 19: 4699-4706 (1980). [PMID: 6893554]

[EC 4.1.1.23 created 1961, modified 1986]