PDBsum entry 2kbx

Cell adhesion

PDB id: 2kbx

Contents

Protein chains

171 a.a. *

70 a.a. *

Metals

_ZN ×2

* Residue conservation analysis

PDB id:

2kbx

Name:

Cell adhesion

Title:

Solution structure of ilk-pinch complex

Structure:

Integrin-linked protein kinase. Chain: a. Fragment: n-terminal domain. Synonym: ilk-1, ilk-2, 59 kda serine/threonine-protein kinase, p59ilk. Engineered: yes. Lim and senescent cell antigen-like-containing domain protein 1. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ilk, ilk1, ilk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: lims1, pinch, pinch1.

NMR struc:

20 models

Authors:

J.Qin

Key ref:

J.Qin Cytosketal proteins. To be published, .

Date:

10-Dec-08 Release date: 30-Dec-08

Protein chain

Q13418  (ILK_HUMAN) -  Scaffold protein ILK from Homo sapiens

Seq: 452 a.a.

Struc: 171 a.a.

Protein chain

P48059  (LIMS1_HUMAN) -  LIM and senescent cell antigen-like-containing domain protein 1 from Homo sapiens

Seq: 325 a.a.

Struc: 70 a.a.

Enzyme reactions

• Enzyme class: Chain A: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site