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PDBsum entry 1vsw
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Contents |
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* Residue conservation analysis
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Obsolete entry |
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PDB id:
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| Name: |
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Transferase
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Title:
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Crystal structure of lumazine synthase from bacillus anthracis
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Structure:
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6,7-dimethyl-8-ribityllumazine synthase. Chain: a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v, w, x, y, z, 1, 2, 3, 4. Synonym: riboflavin synthase beta chain, lumazine synthase. Engineered: yes
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Source:
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Bacillus anthracis. Organism_taxid: 1392. Gene: ribh. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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3.50Å
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R-factor:
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0.236
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R-free:
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0.286
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Authors:
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E.Morgunova,B.Illarionov,S.Saller,A.Popov,T.Sambaiah,A.Bacher, M.Cushman,M.Fischer,R.Ladenstein
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Key ref:
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E.Morgunova
et al.
(2010).
Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase from Bacillus anthracis.
Acta Crystallogr D Biol Crystallogr,
66,
1001-1011.
PubMed id:
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Date:
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16-Sep-09
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Release date:
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10-Nov-10
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PROCHECK
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Headers
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References
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Q81MB5
(RISB_BACAN) -
6,7-dimethyl-8-ribityllumazine synthase from Bacillus anthracis
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Seq:
Struc:
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153 a.a.
152 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.5.1.78
- 6,7-dimethyl-8-ribityllumazine synthase.
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Reaction:
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(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H+
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(2S)-2-hydroxy-3-oxobutyl phosphate
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+
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5-amino-6-(D-ribitylamino)uracil
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=
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6,7-dimethyl-8-(1-D-ribityl)lumazine
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+
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phosphate
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+
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2
×
H2O
Bound ligand (Het Group name = )
corresponds exactly
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Acta Crystallogr D Biol Crystallogr
66:1001-1011
(2010)
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PubMed id:
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Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase from Bacillus anthracis.
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E.Morgunova,
B.Illarionov,
S.Saller,
A.Popov,
T.Sambaiah,
A.Bacher,
M.Cushman,
M.Fischer,
R.Ladenstein.
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ABSTRACT
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Links
