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UniProt functional annotation for Q81MB5 | ||
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| UniProt code: Q81MB5. |
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| Organism: | |
Bacillus anthracis. |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus; Bacillus cereus group. |
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| Function: | |
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. {ECO:0000255|HAMAP-Rule:MF_00178, ECO:0000269|PubMed:20823551}. |
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| Catalytic activity: | |
Reaction=(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D- ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate; Xref=Rhea:RHEA:26152, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15934, ChEBI:CHEBI:43474, ChEBI:CHEBI:58201, ChEBI:CHEBI:58830; EC=2.5.1.78; Evidence={ECO:0000255|HAMAP-Rule:MF_00178, ECO:0000269|PubMed:20823551}; |
| Activity regulation: | |
Activity is competitively inhibited by the bisubstrate-type compounds TS23, JC33 and JC72, with Ki values in the low nanomolar range. {ECO:0000269|PubMed:20823551}. |
| Pathway: | |
Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D- ribitylamino)uracil: step 1/2. {ECO:0000255|HAMAP-Rule:MF_00178}. |
| Subunit: | |
Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers. {ECO:0000255|HAMAP-Rule:MF_00178, ECO:0000269|PubMed:20823551}. |
| Similarity: | |
Belongs to the DMRL synthase family. {ECO:0000255|HAMAP- Rule:MF_00178}. |
Annotations taken from UniProtKB at the EBI.