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PDBsum entry 1be9

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protein ligands links
Peptide recognition PDB id
1be9
Jmol
Contents
Protein chain
115 a.a. *
Ligands
LYS-GLN-THR-SER-
VAL
Waters ×146
* Residue conservation analysis
PDB id:
1be9
Name: Peptide recognition
Title: The third pdz domain from the synaptic protein psd-95 in com a c-terminal peptide derived from cript.
Structure: Psd-95. Chain: a. Fragment: the third pdz domain of psd-95. Engineered: yes. Cript. Chain: b. Fragment: c-terminal peptide
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Biol. unit: Dodecamer (from PQS)
Resolution:
1.82Å     R-factor:   0.207     R-free:   0.278
Authors: D.A.Doyle,A.Lee,J.Lewis,E.Kim,M.Sheng,R.Mackinnon
Key ref:
D.A.Doyle et al. (1996). Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell, 85, 1067-1076. PubMed id: 8674113 DOI: 10.1016/S0092-8674(00)81307-0
Date:
20-May-98     Release date:   21-Oct-98    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P31016  (DLG4_RAT) -  Disks large homolog 4
Seq:
Struc:
 
Seq:
Struc:
724 a.a.
115 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 15 residue positions (black crosses)

 

 
DOI no: 10.1016/S0092-8674(00)81307-0 Cell 85:1067-1076 (1996)
PubMed id: 8674113  
 
 
Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.
D.A.Doyle, A.Lee, J.Lewis, E.Kim, M.Sheng, R.MacKinnon.
 
  ABSTRACT  
 
Modular PDZ domains, found in many cell junction-associated proteins, mediate the clustering of membrane ion channels by binding to their C-terminus. The X-ray crystallographic structures of the third PDZ domain from the synaptic protein PSD-95 in complex with and in the absence of its peptide ligand have been determined at 1.8 angstroms and 2.3 angstroms resolution, respectively. The structures reveal that a four-residue C-terminal stretch (X-Thr/Ser-X-Val-COO(-)) engages the PDZ domain through antiparallel main chain interactions with a beta sheet of the domain. Recognition of the terminal carboxylate group of the peptide is conferred by a cradle of main chain amides provided by a Gly-Leu-Gly-Phe loop as well as by an arginine side chain. Specific side chain interactions and a prominent hydrophobic pocket explain the selective recognition of the C-terminal consensus sequence.
 
  Selected figure(s)  
 
Figure 4.
Figure 4. Chemical Interactions Involved in Peptide Binding(A) Stereo view of the peptide-binding site demonstrating protein–peptide interactions via hydrogen bonds (dashed white lines) and the location of the Val 0 side chain in the hydrophobic pocket. Oxygen atoms are shown in red and nitrogen atoms in blue. The green sphere shows a well-ordered water molecule linking the carboxylate group to Arg-318. The picture was drawn with MOLSCRIPT and Raster3D.(B) Schematic view of the contacts identified in the crystal structure of the complex. Dashed lines represent hydrogen bonds, and the two closest atom-to-atom distances between the Val 0 side chain and all atoms in the hydrophobic pocket of the PDZ domain are drawn as solid black lines. The Val 0 side chain makes numerous other Van der Waals contacts within the range of 3.9 to 4.3 Å; however, for clarity they are not indicated in this diagram. The fixed orientation of the arginine guanidinium head group via hydrogen bonds with backbone carbonyl groups is also shown.
Figure 6.
Figure 6. Schematic Drawing of a PDZ and an IRS-1 PTB DomainA shared peptide-binding motif is highlighted in red. In both domains bound peptide, shown in yellow, forms an antiparallel β sheet with the β strand flanking the peptide-binding groove. The schematic of the IRS-1 PTB domain is based on [39].
 
  The above figures are reprinted by permission from Cell Press: Cell (1996, 85, 1067-1076) copyright 1996.  
  Figures were selected by an automated process.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
21530246 A.Vogrig, B.Boucherle, H.Deokar, I.Thomas, I.Ripoche, L.Y.Lian, and S.Ducki (2011).
NMR evaluation of interactions between substituted-indole and PDZ1 domain of PSD-95.
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21422294 B.Balana, I.Maslennikov, W.Kwiatkowski, K.M.Stern, L.Bahima, S.Choe, and P.A.Slesinger (2011).
Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27.
  Proc Natl Acad Sci U S A, 108, 5831-5836.
PDB codes: 3qdo 3qe1 3qgl
21525870 D.Gfeller, F.Butty, M.Wierzbicka, E.Verschueren, P.Vanhee, H.Huang, A.Ernst, N.Dar, I.Stagljar, L.Serrano, S.S.Sidhu, G.D.Bader, and P.M.Kim (2011).
The multiple-specificity landscape of modular peptide recognition domains.
  Mol Syst Biol, 7, 484.  
20461427 K.Kaufmann, N.Shen, L.Mizoue, and J.Meiler (2011).
A physical model for PDZ-domain/peptide interactions.
  J Mol Model, 17, 315-324.  
21300698 K.Luck, and G.Travé (2011).
Phage display can select over-hydrophobic sequences that may impair prediction of natural domain-peptide interactions.
  Bioinformatics, 27, 899-902.  
21186349 M.Sainlos, C.Tigaret, C.Poujol, N.B.Olivier, L.Bard, C.Breillat, K.Thiolon, D.Choquet, and B.Imperiali (2011).
Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization.
  Nat Chem Biol, 7, 81-91.
PDB code: 3gsl
  21326233 N.Charizopoulou, A.Lelli, M.Schraders, K.Ray, M.S.Hildebrand, A.Ramesh, C.R.Srisailapathy, J.Oostrik, R.J.Admiraal, H.R.Neely, J.R.Latoche, R.J.Smith, J.K.Northup, H.Kremer, J.R.Holt, and K.Noben-Trauth (2011).
Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human.
  Nat Commun, 2, 201.  
20842623 S.Fournane, S.Charbonnier, A.Chapelle, B.Kieffer, G.Orfanoudakis, G.Travé, M.Masson, and Y.Nominé (2011).
Surface plasmon resonance analysis of the binding of high-risk mucosal HPV E6 oncoproteins to the PDZ1 domain of the tight junction protein MAGI-1.
  J Mol Recognit, 24, 511-523.  
21326199 T.Clausen, M.Kaiser, R.Huber, and M.Ehrmann (2011).
HTRA proteases: regulated proteolysis in protein quality control.
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21227701 T.Kaneko, S.S.Sidhu, and S.S.Li (2011).
Evolving specificity from variability for protein interaction domains.
  Trends Biochem Sci, 36, 183-190.  
20668766 A.Bach, N.Stuhr-Hansen, T.S.Thorsen, N.Bork, I.S.Moreira, K.Frydenvang, S.Padrah, S.B.Christensen, K.L.Madsen, H.Weinstein, U.Gether, and K.Strømgaard (2010).
Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1.
  Org Biomol Chem, 8, 4281-4288.  
20714644 A.Ernst, D.Gfeller, Z.Kan, S.Seshagiri, P.M.Kim, G.D.Bader, and S.S.Sidhu (2010).
Coevolution of PDZ domain-ligand interactions analyzed by high-throughput phage display and deep sequencing.
  Mol Biosyst, 6, 1782-1790.  
20733053 B.E.Lauffer, C.Melero, P.Temkin, C.Lei, W.Hong, T.Kortemme, and M.von Zastrow (2010).
SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane.
  J Cell Biol, 190, 565-574.  
  20052683 B.K.Ho, and D.A.Agard (2010).
Conserved tertiary couplings stabilize elements in the PDZ fold, leading to characteristic patterns of domain conformational flexibility.
  Protein Sci, 19, 398-411.  
20357126 C.Y.Zheng, R.S.Petralia, Y.X.Wang, B.Kachar, and R.J.Wenthold (2010).
SAP102 is a highly mobile MAGUK in spines.
  J Neurosci, 30, 4757-4766.  
20937695 D.Garbett, D.P.LaLonde, and A.Bretscher (2010).
The scaffolding protein EBP50 regulates microvillar assembly in a phosphorylation-dependent manner.
  J Cell Biol, 191, 397-413.  
20237154 D.P.LaLonde, D.Garbett, and A.Bretscher (2010).
A regulated complex of the scaffolding proteins PDZK1 and EBP50 with ezrin contribute to microvillar organization.
  Mol Biol Cell, 21, 1519-1529.  
20823552 F.Pavelcík, and J.Václavík (2010).
Performance of phased rotation, conformation and translation function: accurate protein model building with tripeptidic and tetrapeptidic fragments.
  Acta Crystallogr D Biol Crystallogr, 66, 1012-1023.  
20563762 G.Kock, M.Dicks, R.Heumann, K.S.Erdmann, and R.Stoll (2010).
Sequence-specific 1H, 13C, and 15N assignment of the extended PDZ3 domain of the protein tyrosine phosphatase basophil-like PTP-BL.
  Biomol NMR Assign, 4, 199-202.  
20643966 H.E.Rajapakse, N.Gahlaut, S.Mohandessi, D.Yu, J.R.Turner, and L.W.Miller (2010).
Time-resolved luminescence resonance energy transfer imaging of protein-protein interactions in living cells.
  Proc Natl Acad Sci U S A, 107, 13582-13587.  
20509869 H.J.Lee, and J.J.Zheng (2010).
PDZ domains and their binding partners: structure, specificity, and modification.
  Cell Commun Signal, 8, 8.  
20122916 J.Li, H.Kim, D.G.Aceto, J.Hung, S.Aono, and K.J.Kemphues (2010).
Binding to PKC-3, but not to PAR-3 or to a conventional PDZ domain ligand, is required for PAR-6 function in C. elegans.
  Dev Biol, 340, 88-98.  
20120020 J.M.Elkins, C.Gileadi, L.Shrestha, C.Phillips, J.Wang, J.R.Muniz, and D.A.Doyle (2010).
Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms.
  Protein Sci, 19, 731-741.  
20505086 L.Zheng, J.Zheng, D.S.Whitlon, J.García-Añoveros, and J.R.Bartles (2010).
Targeting of the hair cell proteins cadherin 23, harmonin, myosin XVa, espin, and prestin in an epithelial cell model.
  J Neurosci, 30, 7187-7201.  
20026484 O.Sakarya, C.Conaco, O.Egecioglu, S.A.Solla, T.H.Oakley, and K.S.Kosik (2010).
Evolutionary expansion and specialization of the PDZ domains.
  Mol Biol Evol, 27, 1058-1069.  
20949088 Q.S.Du, C.H.Wang, S.M.Liao, and R.B.Huang (2010).
Correlation analysis for protein evolutionary family based on amino acid position mutations and application in PDZ domain.
  PLoS One, 5, e13207.  
20047332 R.C.Tyler, F.C.Peterson, and B.F.Volkman (2010).
Distal interactions within the par3-VE-cadherin complex.
  Biochemistry, 49, 951-957.
PDB code: 2koh
20591147 S.Kalyoncu, O.Keskin, and A.Gursoy (2010).
Interaction prediction and classification of PDZ domains.
  BMC Bioinformatics, 11, 357.  
20089771 X.Sun, T.Fu, N.Chen, J.Guo, J.Ma, M.Zou, C.Lu, and L.Zhang (2010).
The stromal chloroplast Deg7 protease participates in the repair of photosystem II after photoinhibition in Arabidopsis.
  Plant Physiol, 152, 1263-1273.  
19228696 B.Sulka, H.Lortat-Jacob, R.Terreux, F.Letourneur, and P.Rousselle (2009).
Tyrosine dephosphorylation of the syndecan-1 PDZ binding domain regulates syntenin-1 recruitment.
  J Biol Chem, 284, 10659-10671.  
19828436 C.M.Petit, J.Zhang, P.J.Sapienza, E.J.Fuentes, and A.L.Lee (2009).
Hidden dynamic allostery in a PDZ domain.
  Proc Natl Acad Sci U S A, 106, 18249-18254.  
19173579 D.P.LaLonde, and A.Bretscher (2009).
The scaffold protein PDZK1 undergoes a head-to-tail intramolecular association that negatively regulates its interaction with EBP50.
  Biochemistry, 48, 2261-2271.  
19581411 D.Sengupta, S.Truschel, C.Bachert, and A.D.Linstedt (2009).
Organelle tethering by a homotypic PDZ interaction underlies formation of the Golgi membrane network.
  J Cell Biol, 186, 41-55.  
  19342771 H.Chen, S.Tong, X.Li, J.Wu, Z.Zhu, L.Niu, and M.Teng (2009).
Structure of the second PDZ domain from human zonula occludens 2.
  Acta Crystallogr Sect F Struct Biol Cryst Commun, 65, 327-330.
PDB code: 3e17
19446522 H.Cheng, J.Li, R.Fazlieva, Z.Dai, Z.Bu, and H.Roder (2009).
Autoinhibitory interactions between the PDZ2 and C-terminal domains in the scaffolding protein NHERF1.
  Structure, 17, 660-669.
PDB code: 2jxo
19261811 H.F.Han, and M.C.Beckerle (2009).
The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans.
  Mol Biol Cell, 20, 2361-2370.  
19533032 H.S.Eo, S.Kim, H.Koo, and W.Kim (2009).
A machine learning based method for the prediction of G protein-coupled receptor-binding PDZ domain proteins.
  Mol Cells, 27, 629-634.  
19730672 J.Baussand, and A.Carbone (2009).
A combinatorial approach to detect coevolved amino acid networks in protein families of variable divergence.
  PLoS Comput Biol, 5, e1000488.  
19199833 K.Ellencrona, A.Syed, and M.Johansson (2009).
Flavivirus NS5 associates with host-cell proteins zonula occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2 (RIMS2) via an internal PDZ binding mechanism.
  Biol Chem, 390, 319-323.  
19685007 M.A.Durney, G.Birrane, C.Anklin, A.Soni, and J.A.Ladias (2009).
Solution structure of the human Tax-interacting protein-1.
  J Biomol NMR, 45, 329-334.
PDB code: 2kg2
  20054121 M.Fiorentini, A.K.Nielsen, O.Kristensen, J.S.Kastrup, and M.Gajhede (2009).
Structure of the first PDZ domain of human PSD-93.
  Acta Crystallogr Sect F Struct Biol Cryst Commun, 65, 1254-1257.
PDB code: 2wl7
19388649 M.Sainlos, W.S.Iskenderian, and B.Imperiali (2009).
A general screening strategy for peptide-based fluorogenic ligands: probes for dynamic studies of PDZ domain-mediated interactions.
  J Am Chem Soc, 131, 6680-6682.  
19703402 N.Halabi, O.Rivoire, S.Leibler, and R.Ranganathan (2009).
Protein sectors: evolutionary units of three-dimensional structure.
  Cell, 138, 774-786.  
19421056 O.Kocher, and M.Krieger (2009).
Role of the adaptor protein PDZK1 in controlling the HDL receptor SR-BI.
  Curr Opin Lipidol, 20, 236-241.  
19047374 P.von Nandelstadh, M.Ismail, C.Gardin, H.Suila, I.Zara, A.Belgrano, G.Valle, O.Carpen, and G.Faulkner (2009).
A class III PDZ binding motif in the myotilin and FATZ families binds enigma family proteins: a common link for Z-disc myopathies.
  Mol Cell Biol, 29, 822-834.  
19569188 T.Beuming, R.Farid, and W.Sherman (2009).
High-energy water sites determine peptide binding affinity and specificity of PDZ domains.
  Protein Sci, 18, 1609-1619.  
19153575 W.Feng, and M.Zhang (2009).
Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density.
  Nat Rev Neurosci, 10, 87-99.  
19571134 X.M.Zha, V.Costa, A.M.Harding, L.Reznikov, C.J.Benson, and M.J.Welsh (2009).
ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95.
  J Neurosci, 29, 8438-8446.  
18618698 Y.Kong, and M.Karplus (2009).
Signaling pathways of PDZ2 domain: a molecular dynamics interaction correlation analysis.
  Proteins, 74, 145-154.  
19032804 A.Inanobe, N.Kamiya, S.Murakami, Y.Fukunishi, H.Nakamura, and Y.Kurachi (2008).
In Silico Prediction of the Chemical Block of Human Ether-a-Go-Go-Related Gene (hERG) K(+) Current.
  J Physiol Sci, 58, 459-470.  
17673165 B.E.Brooks, and S.K.Buchanan (2008).
Signaling mechanisms for activation of extracytoplasmic function (ECF) sigma factors.
  Biochim Biophys Acta, 1778, 1930-1945.  
18339805 C.N.Chi, L.Elfström, Y.Shi, T.Snäll, A.Engström, and P.Jemth (2008).
Reassessing a sparse energetic network within a single protein domain.
  Proc Natl Acad Sci U S A, 105, 4679-4684.  
18649183 D.Bouvier, F.Kieken, A.Kellezi, and P.L.Sorgen (2008).
Structural changes in the carboxyl terminus of the gap junction protein connexin 40 caused by the interaction with c-Src and zonula occludens-1.
  Cell Commun Adhes, 15, 107-118.  
18191595 D.Matza, A.Badou, K.S.Kobayashi, K.Goldsmith-Pestana, Y.Masuda, A.Komuro, D.McMahon-Pratt, V.T.Marchesi, and R.A.Flavell (2008).
A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation.
  Immunity, 28, 64-74.  
  18923186 H.Vacher, D.P.Mohapatra, and J.S.Trimmer (2008).
Localization and targeting of voltage-dependent ion channels in mammalian central neurons.
  Physiol Rev, 88, 1407-1447.  
18945679 K.Inaba, M.Suzuki, K.Maegawa, S.Akiyama, K.Ito, and Y.Akiyama (2008).
A Pair of Circularly Permutated PDZ Domains Control RseP, the S2P Family Intramembrane Protease of Escherichia coli.
  J Biol Chem, 283, 35042-35052.  
18042258 K.Werme, M.Wigerius, and M.Johansson (2008).
Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling.
  Cell Microbiol, 10, 696-712.  
18036153 L.Peng, D.C.Popescu, N.Wang, and B.H.Shieh (2008).
Anchoring TRP to the INAD macromolecular complex requires the last 14 residues in its carboxyl terminus.
  J Neurochem, 104, 1526-1535.  
18537874 M.A.Estévez, J.A.Henderson, D.Ahn, X.R.Zhu, G.Poschmann, H.Lübbert, R.Marx, and J.M.Baraban (2008).
The neuronal RhoA GEF, Tech, interacts with the synaptic multi-PDZ-domain-containing protein, MUPP1.
  J Neurochem, 106, 1287-1297.  
18835717 M.O.Steinmetz, and A.Akhmanova (2008).
Capturing protein tails by CAP-Gly domains.
  Trends Biochem Sci, 33, 535-545.  
19033470 N.Calosci, C.N.Chi, B.Richter, C.Camilloni, A.Engström, L.Eklund, C.Travaglini-Allocatelli, S.Gianni, M.Vendruscolo, and P.Jemth (2008).
Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins.
  Proc Natl Acad Sci U S A, 105, 19241-19246.  
18828675 R.Tonikian, Y.Zhang, S.L.Sazinsky, B.Currell, J.H.Yeh, B.Reva, H.A.Held, B.A.Appleton, M.Evangelista, Y.Wu, X.Xin, A.C.Chan, S.Seshagiri, L.A.Lasky, C.Sander, C.Boone, G.D.Bader, and S.S.Sidhu (2008).
A specificity map for the PDZ domain family.
  PLoS Biol, 6, e239.  
18484636 T.Ozawa, and K.Okazaki (2008).
CH/pi hydrogen bonds determine the selectivity of the Src homology 2 domain to tyrosine phosphotyrosyl peptides: an ab initio fragment molecular orbital study.
  J Comput Chem, 29, 2656-2666.  
18842882 W.Zhou, L.Zhang, X.Guoxiang, J.Mojsilovic-Petrovic, K.Takamaya, R.Sattler, R.Huganir, and R.Kalb (2008).
GluR1 controls dendrite growth through its binding partner, SAP97.
  J Neurosci, 28, 10220-10233.  
18799665 X.Chen, C.A.Winters, and T.S.Reese (2008).
Life inside a thin section: tomography.
  J Neurosci, 28, 9321-9327.  
17895993 A.Kurakin, A.Swistowski, S.C.Wu, and D.E.Bredesen (2007).
The PDZ domain as a complex adaptive system.
  PLoS ONE, 2, e953.  
17928286 A.S.Fanning, M.F.Lye, J.M.Anderson, and A.Lavie (2007).
Domain swapping within PDZ2 is responsible for dimerization of ZO proteins.
  J Biol Chem, 282, 37710-37716.
PDB code: 2rcz
17404222 D.J.Samuelson, S.E.Hesselson, B.A.Aperavich, Y.Zan, J.D.Haag, A.Trentham-Dietz, J.M.Hampton, B.Mau, K.S.Chen, C.Baynes, K.T.Khaw, R.Luben, B.Perkins, M.Shah, P.D.Pharoah, A.M.Dunning, D.F.Easton, B.A.Ponder, and M.N.Gould (2007).
Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk.
  Proc Natl Acad Sci U S A, 104, 6299-6304.  
17854350 D.R.Marks, and D.A.Fadool (2007).
Post-synaptic density perturbs insulin-induced Kv1.3 channel modulation via a clustering mechanism involving the SH3 domain.
  J Neurochem, 103, 1608-1627.  
17474715 D.Saro, T.Li, C.Rupasinghe, A.Paredes, N.Caspers, and M.R.Spaller (2007).
A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95.
  Biochemistry, 46, 6340-6352.  
17242191 F.C.Morales, Y.Takahashi, S.Momin, H.Adams, X.Chen, and M.M.Georgescu (2007).
NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands.
  Mol Cell Biol, 27, 2527-2537.  
17277057 J.Iwanczyk, D.Damjanovic, J.Kooistra, V.Leong, A.Jomaa, R.Ghirlando, and J.Ortega (2007).
Role of the PDZ domains in Escherichia coli DegP protein.
  J Bacteriol, 189, 3176-3186.  
17613530 J.Li, P.I.Poulikakos, Z.Dai, J.R.Testa, D.J.Callaway, and Z.Bu (2007).
Protein kinase C phosphorylation disrupts Na+/H+ exchanger regulatory factor 1 autoinhibition and promotes cystic fibrosis transmembrane conductance regulator macromolecular assembly.
  J Biol Chem, 282, 27086-27099.  
17384233 J.M.Elkins, E.Papagrigoriou, G.Berridge, X.Yang, C.Phillips, C.Gileadi, P.Savitsky, and D.A.Doyle (2007).
Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
  Protein Sci, 16, 683-694.
PDB codes: 2byg 2fcf 2fne 2gzv 2he2 2he4 2i1n 2iwn 2iwo 2iwp 2iwq
17553932 M.Joch, A.R.Ase, C.X.Chen, P.A.MacDonald, M.Kontogiannea, A.T.Corera, A.Brice, P.Séguéla, and E.A.Fon (2007).
Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels.
  Mol Biol Cell, 18, 3105-3118.  
17828261 M.L.Lunn, R.Nassirpour, C.Arrabit, J.Tan, I.McLeod, C.M.Arias, P.E.Sawchenko, J.R.Yates, and P.A.Slesinger (2007).
A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction.
  Nat Neurosci, 10, 1249-1259.  
17563362 M.Mishima, R.Maesaki, M.Kasa, T.Watanabe, M.Fukata, K.Kaibuchi, and T.Hakoshima (2007).
Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition.
  Proc Natl Acad Sci U S A, 104, 10346-10351.
PDB codes: 2e3h 2e3i 2e4h
17279591 M.Paduch, M.Biernat, P.Stefanowicz, Z.S.Derewenda, Z.Szewczuk, and J.Otlewski (2007).
Bivalent peptides as models for multimeric targets of PDZ domains.
  Chembiochem, 8, 443-452.  
17932789 O.Gileadi, S.Knapp, W.H.Lee, B.D.Marsden, S.Müller, F.H.Niesen, K.L.Kavanagh, L.J.Ball, F.von Delft, D.A.Doyle, U.C.Oppermann, and M.Sundström (2007).
The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins.
  J Struct Funct Genomics, 8, 107-119.  
17551586 O.Sakarya, K.A.Armstrong, M.Adamska, M.Adamski, I.F.Wang, B.Tidor, B.M.Degnan, T.H.Oakley, and K.S.Kosik (2007).
A post-synaptic scaffold at the origin of the animal kingdom.
  PLoS ONE, 2, e506.  
17973281 P.Boisguerin, B.Ay, G.Radziwill, R.D.Fritz, K.Moelling, and R.Volkmer (2007).
Characterization of a putative phosphorylation switch: adaptation of SPOT synthesis to analyze PDZ domain regulation mechanisms.
  Chembiochem, 8, 2302-2307.  
17085449 P.Kuballa, K.Matentzoglu, and M.Scheffner (2007).
The role of the ubiquitin ligase E6-AP in human papillomavirus E6-mediated degradation of PDZ domain-containing proteins.
  J Biol Chem, 282, 65-71.  
17923089 P.Mishra, M.Socolich, M.A.Wall, J.Graves, Z.Wang, and R.Ranganathan (2007).
Dynamic scaffolding in a G protein-coupled signaling system.
  Cell, 131, 80-92.
PDB codes: 2qkt 2qku 2qkv
17473018 Q.Chen, X.Niu, Y.Xu, J.Wu, and Y.Shi (2007).
Solution structure and backbone dynamics of the AF-6 PDZ domain/Bcr peptide complex.
  Protein Sci, 16, 1053-1062.
PDB code: 2ain
17631635 S.P.Lad, G.Yang, D.A.Scott, G.Wang, P.Nair, J.Mathison, V.S.Reddy, and E.Li (2007).
Chlamydial CT441 is a PDZ domain-containing tail-specific protease that interferes with the NF-kappaB pathway of immune response.
  J Bacteriol, 189, 6619-6625.  
17610064 W.L.Wang, S.F.Yeh, E.Y.Huang, Y.L.Lu, C.F.Wang, C.Y.Huang, and W.J.Lin (2007).
Mitochondrial anchoring of PKCalpha by PICK1 confers resistance to etoposide-induced apoptosis.
  Apoptosis, 12, 1857-1871.  
18078379 X.Chen, J.C.Longgood, C.Michnoff, S.Wei, D.E.Frantz, and L.Bezprozvanny (2007).
High-throughput screen for small molecule inhibitors of Mint1-PDZ domains.
  Assay Drug Dev Technol, 5, 769-783.  
17267502 Y.Zhang, J.Dasgupta, R.Z.Ma, L.Banks, M.Thomas, and X.S.Chen (2007).
Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein.
  J Virol, 81, 3618-3626.
PDB codes: 2i04 2i0i 2i0l
  16796391 A.Piserchio, M.Spaller, and D.F.Mierke (2006).
Targeting the PDZ domains of molecular scaffolds of transmembrane ion channels.
  AAPS J, 8, E396-E401.  
16737969 B.A.Appleton, Y.Zhang, P.Wu, J.P.Yin, W.Hunziker, N.J.Skelton, S.S.Sidhu, and C.Wiesmann (2006).
Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
  J Biol Chem, 281, 22312-22320.
PDB codes: 2h2b 2h2c 2h3l 2h3m
16855024 C.Alewine, O.Olsen, J.B.Wade, and P.A.Welling (2006).
TIP-1 has PDZ scaffold antagonist activity.
  Mol Biol Cell, 17, 4200-4211.  
17018532 C.N.Chi, A.Engström, S.Gianni, M.Larsson, and P.Jemth (2006).
Two conserved residues govern the salt and pH dependencies of the binding reaction of a PDZ domain.
  J Biol Chem, 281, 36811-36818.  
17096593 D.Korkin, F.P.Davis, F.Alber, T.Luong, M.Y.Shen, V.Lucic, M.B.Kennedy, and A.Sali (2006).
Structural modeling of protein interactions by analogy: application to PSD-95.
  PLoS Comput Biol, 2, e153.  
16436508 E.McNeil, C.T.Capaldo, and I.G.Macara (2006).
Zonula occludens-1 function in the assembly of tight junctions in Madin-Darby canine kidney epithelial cells.
  Mol Biol Cell, 17, 1922-1932.  
16741958 H.Kusunoki, and T.Kohno (2006).
Solution structure of human erythroid p55 PDZ domain.
  Proteins, 64, 804-807.
PDB code: 2ev8
16828554 H.Remaut, and G.Waksman (2006).
Protein-protein interaction through beta-strand addition.
  Trends Biochem Sci, 31, 436-444.  
17069616 I.von Ossowski, E.Oksanen, L.von Ossowski, C.Cai, M.Sundberg, A.Goldman, and K.Keinänen (2006).
Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptide.
  FEBS J, 273, 5219-5229.
PDB codes: 2awu 2aww 2awx 2g2l
16835239 K.Matsuda, S.Matsuda, C.M.Gladding, and M.Yuzaki (2006).
Characterization of the delta2 glutamate receptor-binding protein delphilin: Splicing variants with differential palmitoylation and an additional PDZ domain.
  J Biol Chem, 281, 25577-25587.  
16933296 K.Sharp, and J.J.Skinner (2006).
Pump-probe molecular dynamics as a tool for studying protein motion and long range coupling.
  Proteins, 65, 347-361.  
16671149 M.Joshi, C.Vargas, P.Boisguerin, A.Diehl, G.Krause, P.Schmieder, K.Moelling, V.Hagen, M.Schade, and H.Oschkinat (2006).
Discovery of low-molecular-weight ligands for the AF6 PDZ domain.
  Angew Chem Int Ed Engl, 45, 3790-3795.
PDB codes: 1xz9 2exg
16283201 M.L.Chapman, M.L.Blanke, H.S.Krovetz, and A.M.Vandongen (2006).
Allosteric effects of external K(+) ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K(+) channel.
  Pflugers Arch, 451, 776-792.  
16553463 M.Nawrot, T.Liu, G.G.Garwin, J.W.Crabb, and J.C.Saari (2006).
Scaffold proteins and the regeneration of visual pigments.
  Photochem Photobiol, 82, 1482-1488.  
17002371 N.Basdevant, H.Weinstein, and M.Ceruso (2006).
Thermodynamic basis for promiscuity and selectivity in protein-protein interactions: PDZ domains, a case study.
  J Am Chem Soc, 128, 12766-12777.  
16908530 N.Latysheva, G.Muratov, S.Rajesh, M.Padgett, N.A.Hotchin, M.Overduin, and F.Berditchevski (2006).
Syntenin-1 is a new component of tetraspanin-enriched microdomains: mechanisms and consequences of the interaction of syntenin-1 with CD63.
  Mol Cell Biol, 26, 7707-7718.  
16929102 R.Pai, J.Sacchettini, and T.Ioerger (2006).
Identifying non-crystallographic symmetry in protein electron-density maps: a feature-based approach.
  Acta Crystallogr D Biol Crystallogr, 62, 1012-1021.  
16849232 S.Fletcher, and A.D.Hamilton (2006).
Targeting protein-protein interactions by rational design: mimicry of protein surfaces.
  J R Soc Interface, 3, 215-233.  
16456542 Y.Takahashi, F.C.Morales, E.L.Kreimann, and M.M.Georgescu (2006).
PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling.
  EMBO J, 25, 910-920.  
18615145 Y.X.Tao, and R.A.Johns (2006).
PDZ domains at excitatory synapses: potential molecular targets for persistent pain treatment.
  Curr Neuropharmacol, 4, 217-223.  
16737968 Y.Zhang, S.Yeh, B.A.Appleton, H.A.Held, P.J.Kausalya, D.C.Phua, W.L.Wong, L.A.Lasky, C.Wiesmann, W.Hunziker, and S.S.Sidhu (2006).
Convergent and divergent ligand specificity among PDZ domains of the LAP and zonula occludens (ZO) families.
  J Biol Chem, 281, 22299-22311.  
16132821 A.E.Duquesne, M.Ruijter, J.Brouwer, J.W.Drijfhout, S.B.Nabuurs, C.A.Spronk, G.W.Vuister, M.Ubbink, and G.W.Canters (2005).
Solution structure of the second PDZ domain of the neuronal adaptor X11alpha and its interaction with the C-terminal peptide of the human copper chaperone for superoxide dismutase.
  J Biomol NMR, 32, 209-218.
PDB code: 1y7n
15767854 A.Yesilaltay, O.Kocher, A.Rigotti, and M.Krieger (2005).
Regulation of SR-BI-mediated high-density lipoprotein metabolism by the tissue-specific adaptor protein PDZK1.
  Curr Opin Lipidol, 16, 147-152.  
16123035 B.Coblitz, S.Shikano, M.Wu, S.B.Gabelli, L.M.Cockrell, M.Spieker, Y.Hanyu, H.Fu, L.M.Amzel, and M.Li (2005).
C-terminal recognition by 14-3-3 proteins for surface expression of membrane receptors.
  J Biol Chem, 280, 36263-36272.  
15787971 C.Sun, and D.F.Mierke (2005).
Characterization of interactions of Na+/H+ exchanger regulatory factor-1 with the parathyroid hormone receptor and phospholipase C.
  J Pept Res, 65, 411-417.  
15647374 D.R.Glodowski, T.Wright, K.Martinowich, H.C.Chang, D.Beach, and C.Rongo (2005).
Distinct LIN-10 domains are required for its neuronal function, its epithelial function, and its synaptic localization.
  Mol Biol Cell, 16, 1417-1426.  
16283141 E.Kalay, A.P.de Brouwer, R.Caylan, S.B.Nabuurs, B.Wollnik, A.Karaguzel, J.G.Heister, H.Erdol, F.P.Cremers, C.W.Cremers, H.G.Brunner, and H.Kremer (2005).
A novel D458V mutation in the SANS PDZ binding motif causes atypical Usher syndrome.
  J Mol Med, 83, 1025-1032.  
15684424 H.Zhou, Y.Xu, Y.Yang, A.Huang, J.Wu, and Y.Shi (2005).
Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr.
  J Biol Chem, 280, 13841-13847.
PDB code: 1t2m
15774468 K.L.Madsen, T.Beuming, M.Y.Niv, C.W.Chang, K.K.Dev, H.Weinstein, and U.Gether (2005).
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1.
  J Biol Chem, 280, 20539-20548.  
15952887 L.Funke, S.Dakoji, and D.S.Bredt (2005).
Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions.
  Annu Rev Biochem, 74, 219-245.  
15929985 L.Wang, A.Piserchio, and D.F.Mierke (2005).
Structural characterization of the intermolecular interactions of synapse-associated protein-97 with the NR2B subunit of N-methyl-D-aspartate receptors.
  J Biol Chem, 280, 26992-26996.
PDB code: 1zok
15678420 M.Groll, M.Bochtler, H.Brandstetter, T.Clausen, and R.Huber (2005).
Molecular machines for protein degradation.
  Chembiochem, 6, 222-256.  
15951562 M.Valiente, A.Andrés-Pons, B.Gomar, J.Torres, A.Gil, C.Tapparel, S.E.Antonarakis, and R.Pulido (2005).
Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases.
  J Biol Chem, 280, 28936-28943.  
15821164 P.De Los Rios, F.Cecconi, A.Pretre, G.Dietler, O.Michielin, F.Piazza, and B.Juanico (2005).
Functional dynamics of PDZ binding domains: a normal-mode analysis.
  Biophys J, 89, 14-21.  
16125112 P.R.Cao, H.J.Kim, and S.H.Lecker (2005).
Ubiquitin-protein ligases in muscle wasting.
  Int J Biochem Cell Biol, 37, 2088-2097.  
16049001 S.Gianni, A.Engström, M.Larsson, N.Calosci, F.Malatesta, L.Eklund, C.C.Ngang, C.Travaglini-Allocatelli, and P.Jemth (2005).
The kinetics of PDZ domain-ligand interactions and implications for the binding mechanism.
  J Biol Chem, 280, 34805-34812.  
15698575 T.Cierpicki, J.H.Bushweller, and Z.S.Derewenda (2005).
Probing the supramodular architecture of a multidomain protein: the structure of syntenin in solution.
  Structure, 13, 319-327.  
16194281 T.J.Magliery, and L.Regan (2005).
Sequence variation in ligand binding sites in proteins.
  BMC Bioinformatics, 6, 240.  
15994182 W.R.Thelin, C.A.Hodson, and S.L.Milgram (2005).
Beyond the brush border: NHERF4 blazes new NHERF turf.
  J Physiol, 567, 13-19.  
15023994 A.A.Fodor, and R.W.Aldrich (2004).
On evolutionary conservation of thermodynamic coupling in proteins.
  J Biol Chem, 279, 19046-19050.  
15123241 A.Piserchio, G.D.Salinas, T.Li, J.Marshall, M.R.Spaller, and D.F.Mierke (2004).
Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide.
  Chem Biol, 11, 469-473.
PDB code: 1rgr
15359277 B.Ritter, A.Y.Denisov, J.Philie, C.Deprez, E.C.Tung, K.Gehring, and P.S.McPherson (2004).
Two WXXF-based motifs in NECAPs define the specificity of accessory protein binding to AP-1 and AP-2.
  EMBO J, 23, 3701-3710.  
15047711 C.Castillejo-López, W.M.Arias, and S.Baumgartner (2004).
The fat-like gene of Drosophila is the true orthologue of vertebrate fat cadherins and is involved in the formation of tubular organs.
  J Biol Chem, 279, 24034-24043.  
14960011 C.Fehr, R.L.Shirley, P.Metten, A.E.Kosobud, J.K.Belknap, J.C.Crabbe, and K.J.Buck (2004).
Potential pleiotropic effects of Mpdz on vulnerability to seizures.
  Genes Brain Behav, 3, 8.  
15469991 C.S.Lazar, C.M.Cresson, D.A.Lauffenburger, and G.N.Gill (2004).
The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface.
  Mol Biol Cell, 15, 5470-5480.  
15137941 C.Wilken, K.Kitzing, R.Kurzbauer, M.Ehrmann, and T.Clausen (2004).
Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease.
  Cell, 117, 483-494.
PDB codes: 1sot 1soz 1vcw
15378037 E.Kim, and M.Sheng (2004).
PDZ domain proteins of synapses.
  Nat Rev Neurosci, 5, 771-781.  
15023337 F.C.Peterson, R.R.Penkert, B.F.Volkman, and K.E.Prehoda (2004).
Cdc42 regulates the Par-6 PDZ domain through an allosteric CRIB-PDZ transition.
  Mol Cell, 13, 665-676.
PDB codes: 1ry4 1rzx
15312654 G.Krapivinsky, I.Medina, L.Krapivinsky, S.Gapon, and D.E.Clapham (2004).
SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation.
  Neuron, 43, 563-574.  
15266631 J.L.Sanford, T.A.Mays, and J.A.Rafael-Fortney (2004).
CASK and Dlg form a PDZ protein complex at the mammalian neuromuscular junction.
  Muscle Nerve, 30, 164-171.  
14679199 J.Y.Kim, W.Han, W.Namkung, J.H.Lee, K.H.Kim, H.Shin, E.Kim, and M.G.Lee (2004).
Inhibitory regulation of cystic fibrosis transmembrane conductance regulator anion-transporting activities by Shank2.
  J Biol Chem, 279, 10389-10396.  
15611336 J.Zeitler, C.P.Hsu, H.Dionne, and D.Bilder (2004).
Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble.
  J Cell Biol, 167, 1137-1146.  
15663004 L.C.van den Berk, M.A.van Ham, M.M.te Lindert, T.Walma, J.Aelen, G.W.Vuister, and W.J.Hendriks (2004).
The interaction of PTP-BL PDZ domains with RIL: an enigmatic role for the RIL LIM domain.
  Mol Biol Rep, 31, 203-215.  
15456900 P.J.Kausalya, D.C.Phua, and W.Hunziker (2004).
Association of ARVCF with zonula occludens (ZO)-1 and ZO-2: binding to PDZ-domain proteins and cell-cell adhesion regulate plasma membrane and nuclear localization of ARVCF.
  Mol Biol Cell, 15, 5503-5515.  
15475968 R.R.Penkert, H.M.DiVittorio, and K.E.Prehoda (2004).
Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex.
  Nat Struct Mol Biol, 11, 1122-1127.
PDB code: 1x8s
15377393 W.Cai, J.Pei, and N.V.Grishin (2004).
Reconstruction of ancestral protein sequences and its applications.
  BMC Evol Biol, 4, 33.  
12593989 A.W.McGee, and D.S.Bredt (2003).
Assembly and plasticity of the glutamatergic postsynaptic specialization.
  Curr Opin Neurobiol, 13, 111-118.  
12842047 B.S.Kang, D.R.Cooper, Y.Devedjiev, U.Derewenda, and Z.S.Derewenda (2003).
Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm.
  Structure, 11, 845-853.
PDB codes: 1nte 1obx 1oby 1obz
12649600 C.C.Yun (2003).
Concerted roles of SGK1 and the Na+/H+ exchanger regulatory factor 2 (NHERF2) in regulation of NHE3.
  Cell Physiol Biochem, 13, 29-40.  
12499364 C.Huang, Q.Zhou, P.Liang, M.S.Hollander, F.Sheikh, X.Li, M.Greaser, G.D.Shelton, S.Evans, and J.Chen (2003).
Characterization and in vivo functional analysis of splice variants of cypher.
  J Biol Chem, 278, 7360-7365.  
14618155 D.Bichet, F.A.Haass, and L.Y.Jan (2003).
Merging functional studies with structures of inward-rectifier K(+) channels.
  Nat Rev Neurosci, 4, 957-967.  
12444095 G.Birrane, J.Chung, and J.A.Ladias (2003).
Novel mode of ligand recognition by the Erbin PDZ domain.
  J Biol Chem, 278, 1399-1402.
PDB codes: 1mfg 1mfl
12679025 J.C.Young, and F.U.Hartl (2003).
A stress sensor for the bacterial periplasm.
  Cell, 113, 1-2.  
14633997 K.Kanehara, K.Ito, and Y.Akiyama (2003).
YaeL proteolysis of RseA is controlled by the PDZ domain of YaeL and a Gln-rich region of RseA.
  EMBO J, 22, 6389-6398.  
14653806 K.S.Erdmann (2003).
The protein tyrosine phosphatase PTP-Basophil/Basophil-like. Interacting proteins and molecular functions.
  Eur J Biochem, 270, 4789-4798.  
12682077 L.L.Parker, J.R.Backstrom, E.Sanders-Bush, and B.H.Shieh (2003).
Agonist-induced phosphorylation of the serotonin 5-HT2C receptor regulates its interaction with multiple PDZ protein 1.
  J Biol Chem, 278, 21576-21583.  
14514674 L.Wang, H.Zeng, P.Wang, S.Soker, and D.Mukhopadhyay (2003).
Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration.
  J Biol Chem, 278, 48848-48860.  
12853458 M.Fang, Y.X.Tao, F.He, M.Zhang, C.F.Levine, P.Mao, F.Tao, C.L.Chou, S.Sadegh-Nasseri, and R.A.Johns (2003).
Synaptic PDZ domain-mediated protein interactions are disrupted by inhalational anesthetics.
  J Biol Chem, 278, 36669-36675.  
12596229 M.Thomson (2003).
Does cholesterol use the mitochondrial contact site as a conduit to the steroidogenic pathway?
  Bioessays, 25, 252-258.  
12839623 M.van Ham, H.Croes, J.Schepens, J.Fransen, B.Wieringa, and W.Hendriks (2003).
Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL.
  Genes Cells, 8, 631-644.  
12923170 N.Bannert, K.Vollhardt, B.Asomuddinov, M.Haag, H.König, S.Norley, and R.Kurth (2003).
PDZ Domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits.
  J Biol Chem, 278, 42190-42199.  
12446668 N.J.Skelton, M.F.Koehler, K.Zobel, W.L.Wong, S.Yeh, M.T.Pisabarro, J.P.Yin, L.A.Lasky, and S.S.Sidhu (2003).
Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain.
  J Biol Chem, 278, 7645-7654.
PDB code: 1n7t
12679035 N.P.Walsh, B.M.Alba, B.Bose, C.A.Gross, and R.T.Sauer (2003).
OMP peptide signals initiate the envelope-stress response by activating DegS protease via relief of inhibition mediated by its PDZ domain.
  Cell, 113, 61-71.  
12556478 O.Kocher, R.Pal, M.Roberts, C.Cirovic, and A.Gilchrist (2003).
Targeted disruption of the PDZK1 gene by homologous recombination.
  Mol Cell Biol, 23, 1175-1180.  
12870871 R.Papp, I.Ekiel, and A.M.English (2003).
ESI-MS and FTIR studies of the interaction between the second PDZ domain of hPTP1E and target peptides.
  Biochem Cell Biol, 81, 71-80.  
12690258 S.H.Lecker, and A.L.Goldberg (2003).
Ubiquitin-protein ligases in muscle wasting: multiple parallel pathways?
  Curr Opin Clin Nutr Metab Care, 6, 271-275.  
12547433 S.S.Sidhu, G.D.Bader, and C.Boone (2003).
Functional genomics of intracellular peptide recognition domains with combinatorial biology methods.
  Curr Opin Chem Biol, 7, 97.  
12719221 T.Sulea, and E.O.Purisima (2003).
Profiling charge complementarity and selectivity for binding at the protein surface.
  Biophys J, 84, 2883-2896.  
14555997 W.Feng, Y.Shi, M.Li, and M.Zhang (2003).
Tandem PDZ repeats in glutamate receptor-interacting proteins have a novel mode of PDZ domain-mediated target binding.
  Nat Struct Biol, 10, 972-978.
PDB codes: 1p1d 1p1e
12954649 Y.J.Im, J.H.Lee, S.H.Park, S.J.Park, S.H.Rho, G.B.Kang, E.Kim, and S.H.Eom (2003).
Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization.
  J Biol Chem, 278, 48099-48104.
PDB codes: 1q3o 1q3p
12209850 A.C.McInvale, J.Staudinger, R.E.Harlan, and M.M.Garcia (2002).
Immunolocalization of PICK1 in the ascending auditory pathways of the adult rat.
  J Comp Neurol, 450, 382-394.  
11744724 A.Piserchio, M.Pellegrini, S.Mehta, S.M.Blackman, E.P.Garcia, J.Marshall, and D.F.Mierke (2002).
The PDZ1 domain of SAP90. Characterization of structure and binding.
  J Biol Chem, 277, 6967-6973.
PDB code: 1kef
11741967 A.Y.Hung, and M.Sheng (2002).
PDZ domains: structural modules for protein complex assembly.
  J Biol Chem, 277, 5699-5702.  
12070168 C.Cai, S.K.Coleman, K.Niemi, and K.Keinänen (2002).
Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif.
  J Biol Chem, 277, 31484-31490.  
12119305 D.L.Silver (2002).
A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver.
  J Biol Chem, 277, 34042-34047.  
12359873 E.Schnell, M.Sizemore, S.Karimzadegan, L.Chen, D.S.Bredt, and R.A.Nicoll (2002).
Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number.
  Proc Natl Acad Sci U S A, 99, 13902-13907.  
11983858 F.Bladt, A.Tafuri, S.Gelkop, L.Langille, and T.Pawson (2002).
Epidermolysis bullosa and embryonic lethality in mice lacking the multi-PDZ domain protein GRIP1.
  Proc Natl Acad Sci U S A, 99, 6816-6821.  
11723117 F.Imamura, S.Maeda, T.Doi, and Y.Fujiyoshi (2002).
Ligand binding of the second PDZ domain regulates clustering of PSD-95 with the Kv1.4 potassium channel.
  J Biol Chem, 277, 3640-3646.  
12214225 G.Yellen (2002).
The voltage-gated potassium channels and their relatives.
  Nature, 419, 35-42.  
12437101 H.Brandstetter, J.S.Kim, M.Groll, P.Göttig, and R.Huber (2002).
Structural basis for the processive protein degradation by tricorn protease.
  Biol Chem, 383, 1157-1165.  
11937501 I.A.Lim, D.D.Hall, and J.W.Hell (2002).
Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102.
  J Biol Chem, 277, 21697-21711.  
12196628 J.Aurandt, H.G.Vikis, J.S.Gutkind, N.Ahn, and K.L.Guan (2002).
The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG.
  Proc Natl Acad Sci U S A, 99, 12085-12090.  
11805122 J.Choi, J.Ko, E.Park, J.R.Lee, J.Yoon, S.Lim, and E.Kim (2002).
Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95.
  J Biol Chem, 277, 12359-12363.  
11859027 J.J.Chung, S.Shikano, Y.Hanyu, and M.Li (2002).
Functional diversity of protein C-termini: more than zipcoding?
  Trends Cell Biol, 12, 146-150.  
12080331 J.Reina, E.Lacroix, S.D.Hobson, G.Fernandez-Ballester, V.Rybin, M.S.Schwab, L.Serrano, and C.Gonzalez (2002).
Computer-aided design of a PDZ domain to recognize new target sequences.
  Nat Struct Biol, 9, 621-627.  
12075354 M.J.Mahon, M.Donowitz, C.C.Yun, and G.V.Segre (2002).
Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling.
  Nature, 417, 858-861.  
11950846 R.O.Scott, W.R.Thelin, and S.L.Milgram (2002).
A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor.
  J Biol Chem, 277, 22934-22941.  
11821434 R.P.Laura, A.S.Witt, H.A.Held, R.Gerstner, K.Deshayes, M.F.Koehler, K.S.Kosik, S.S.Sidhu, and L.A.Lasky (2002).
The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF.
  J Biol Chem, 277, 12906-12914.  
12037318 S.H.Park, Y.J.Im, S.H.Rho, J.H.Lee, S.Yang, E.Kim, and S.H.Eom (2002).
Crystallization and preliminary X-ray crystallographic studies of the sixth PDZ domain of glutamate-receptor interacting protein 1 (GRIP1) from Rattus norvegicus.
  Acta Crystallogr D Biol Crystallogr, 58, 1063-1065.  
11882663 S.Karthikeyan, T.Leung, and J.A.Ladias (2002).
Structural determinants of the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptors.
  J Biol Chem, 277, 18973-18978.
PDB codes: 1gq4 1gq5
11919638 T.Krojer, M.Garrido-Franco, R.Huber, M.Ehrmann, and T.Clausen (2002).
Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine.
  Nature, 416, 455-459.
PDB code: 1ky9
12183458 V.Perrot, J.Vazquez-Prado, and J.S.Gutkind (2002).
Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF.
  J Biol Chem, 277, 43115-43120.  
12196542 W.Feng, J.S.Fan, M.Jiang, Y.W.Shi, and M.Zhang (2002).
PDZ7 of glutamate receptor interacting protein binds to its target via a novel hydrophobic surface area.
  J Biol Chem, 277, 41140-41146.
PDB code: 1m5z
12391161 Y.Pak, N.Pham, and D.Rotin (2002).
Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation.
  Mol Cell Biol, 22, 7942-7952.  
  11141479 A.O.Stemmer-Rachamimov, T.Wiederhold, G.P.Nielsen, M.James, D.Pinney-Michalowski, J.E.Roy, W.A.Cohen, V.Ramesh, and D.N.Louis (2001).
NHE-RF, a merlin-interacting protein, is primarily expressed in luminal epithelia, proliferative endometrium, and estrogen receptor-positive breast carcinomas.
  Am J Pathol, 158, 57-62.  
  11694581 B.L.Firestein, and C.Rongo (2001).
DLG-1 is a MAGUK similar to SAP97 and is required for adherens junction formation.
  Mol Biol Cell, 12, 3465-3475.  
11352727 B.Z.Harris, B.J.Hillier, and W.A.Lim (2001).
Energetic determinants of internal motif recognition by PDZ domains.
  Biochemistry, 40, 5921-5930.  
11544104 C.Rongo (2001).
Disparate cell types use a shared complex of PDZ proteins for polarized protein localization.
  Cytokine Growth Factor Rev, 12, 349-359.  
11430802 D.L.Sherman, C.Fabrizi, C.S.Gillespie, and P.J.Brophy (2001).
Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy.
  Neuron, 30, 677-687.  
11285285 D.Reczek, and A.Bretscher (2001).
Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP.
  J Cell Biol, 153, 191-206.  
11343649 G.E.Torres, W.D.Yao, A.R.Mohn, H.Quan, K.M.Kim, A.I.Levey, J.Staudinger, and M.G.Caron (2001).
Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1.
  Neuron, 30, 121-134.  
11320314 G.Webster, T.Leung, S.Karthikeyan, G.Birrane, and J.A.Ladias (2001).
Crystallographic characterization of the PDZ1 domain of the human Na+/H+ exchanger regulatory factor.
  Acta Crystallogr D Biol Crystallogr, 57, 714-716.  
11292808 H.Zhao, Z.M.Shen, P.C.Kahn, and P.N.Lipke (2001).
Interaction of alpha-agglutinin and a-agglutinin, Saccharomyces cerevisiae sexual cell adhesion molecules.
  J Bacteriol, 183, 2874-2880.  
11520913 J.Birkenfeld, H.Betz, and D.Roth (2001).
Inhibition of neurite extension by overexpression of individual domains of LIM kinase 1.
  J Neurochem, 78, 924-927.  
11470431 K.L.Longenecker, M.E.Lewis, H.Chikumi, J.S.Gutkind, and Z.S.Derewenda (2001).
Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases.
  Structure, 9, 559-569.
PDB code: 1htj
11717410 M.D.Gomes, S.H.Lecker, R.T.Jagoe, A.Navon, A.L.Goldberg, and A.L.Goldberg (2001).
Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy.
  Proc Natl Acad Sci U S A, 98, 14440-14445.  
11571312 M.E.Adams, H.A.Mueller, and S.C.Froehner (2001).
In vivo requirement of the alpha-syntrophin PDZ domain for the sarcolemmal localization of nNOS and aquaporin-4.
  J Cell Biol, 155, 113-122.  
11500369 M.E.Kimple, D.P.Siderovski, and J.Sondek (2001).
Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA.
  EMBO J, 20, 4414-4422.
PDB code: 1ihj
11466320 M.S.Kalo, H.H.Yu, and E.B.Pasquale (2001).
In vivo tyrosine phosphorylation sites of activated ephrin-B1 and ephB2 from neural tissue.
  J Biol Chem, 276, 38940-38948.  
11416187 M.Sheng (2001).
Molecular organization of the postsynaptic specialization.
  Proc Natl Acad Sci U S A, 98, 7058-7061.  
11283303 M.Sheng, and C.Sala (2001).
PDZ domains and the organization of supramolecular complexes.
  Annu Rev Neurosci, 24, 1.  
11498591 N.Geijsen, I.J.Uings, C.Pals, J.Armstrong, M.McKinnon, J.A.Raaijmakers, J.W.Lammers, L.Koenderman, and P.J.Coffer (2001).
Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein.
  Science, 293, 1136-1138.  
11418578 N.T.Hoa, J.A.Brannigan, and S.M.Cutting (2001).
The PDZ domain of the SpoIVB serine peptidase facilitates multiple functions.
  J Bacteriol, 183, 4364-4373.  
11509564 P.Vaccaro, B.Brannetti, L.Montecchi-Palazzi, S.Philipp, M.Helmer Citterich, G.Cesareni, and L.Dente (2001).
Distinct binding specificity of the multiple PDZ domains of INADL, a human protein with homology to INAD from Drosophila melanogaster.
  J Biol Chem, 276, 42122-42130.  
11553623 Q.Zhang, J.S.Fan, and M.Zhang (2001).
Interdomain chaperoning between PSD-95, Dlg, and Zo-1 (PDZ) domains of glutamate receptor-interacting proteins.
  J Biol Chem, 276, 43216-43220.  
11696561 Q.Zhou, P.H.Chu, C.Huang, C.F.Cheng, M.E.Martone, G.Knoll, G.D.Shelton, S.Evans, and J.Chen (2001).
Ablation of Cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathy.
  J Cell Biol, 155, 605-612.  
11463840 S.Galande, L.A.Dickinson, I.S.Mian, M.Sikorska, and T.Kohwi-Shigematsu (2001).
SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis.
  Mol Cell Biol, 21, 5591-5604.  
11231355 T.Inoue, E.Yaoita, H.Kurihara, F.Shimizu, T.Sakai, T.Kobayashi, K.Ohshiro, H.Kawachi, H.Okada, H.Suzuki, I.Kihara, and T.Yamamoto (2001).
FAT is a component of glomerular slit diaphragms.
  Kidney Int, 59, 1003-1012.  
11158634 V.Raghuram, D.O.Mak, and J.K.Foskett (2001).
Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction.
  Proc Natl Acad Sci U S A, 98, 1300-1305.  
10629225 A.M.Tiffany, L.N.Manganas, E.Kim, Y.P.Hsueh, M.Sheng, and J.S.Trimmer (2000).
PSD-95 and SAP97 exhibit distinct mechanisms for regulating K(+) channel surface expression and clustering.
  J Cell Biol, 148, 147-158.  
10856930 C.C.Garner, J.Nash, and R.L.Huganir (2000).
PDZ domains in synapse assembly and signalling.
  Trends Cell Biol, 10, 274-280.  
10786835 C.Scheufler, A.Brinker, G.Bourenkov, S.Pegoraro, L.Moroder, H.Bartunik, F.U.Hartl, and I.Moarefi (2000).
Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine.
  Cell, 101, 199-210.
PDB codes: 1elr 1elw
10625685 D.G.Jugloff, R.Khanna, L.C.Schlichter, and O.T.Jones (2000).
Internalization of the Kv1.4 potassium channel is suppressed by clustering interactions with PSD-95.
  J Biol Chem, 275, 1357-1364.  
10828067 D.J.Nevrivy, V.J.Peterson, D.Avram, J.E.Ishmael, S.G.Hansen, P.Dowell, D.E.Hruby, M.I.Dawson, and M.Leid (2000).
Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors.
  J Biol Chem, 275, 16827-16836.  
11080160 D.J.Owen, P.Ornaghi, J.C.Yang, N.Lowe, P.R.Evans, P.Ballario, D.Neuhaus, P.Filetici, and A.A.Travers (2000).
The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p.
  EMBO J, 19, 6141-6149.
PDB code: 1e6i
  10887205 G.Fuh, M.T.Pisabarro, Y.Li, C.Quan, L.A.Lasky, and S.S.Sidhu (2000).
Analysis of PDZ domain-ligand interactions using carboxyl-terminal phage display.
  J Biol Chem, 275, 21486-21491.  
10704206 G.Kozlov, K.Gehring, and I.Ekiel (2000).
Solution structure of the PDZ2 domain from human phosphatase hPTP1E and its interactions with C-terminal peptides from the Fas receptor.
  Biochemistry, 39, 2572-2580.
PDB code: 3pdz
11060025 H.Wu, C.Reissner, S.Kuhlendahl, B.Coblentz, S.Reuver, S.Kindler, E.D.Gundelfinger, and C.C.Garner (2000).
Intramolecular interactions regulate SAP97 binding to GKAP.
  EMBO J, 19, 5740-5751.  
10644767 K.Hirao, Y.Hata, I.Yao, M.Deguchi, H.Kawabe, A.Mizoguchi, and Y.Takai (2000).
Three isoforms of synaptic scaffolding molecule and their characterization. Multimerization between the isoforms and their interaction with N-methyl-D-aspartate receptors and SAP90/PSD-95-associated protein.
  J Biol Chem, 275, 2966-2972.  
10766855 M.Liu, L.L.Parker, B.E.Wadzinski, and B.H.Shieh (2000).
Reversible phosphorylation of the signal transduction complex in Drosophila photoreceptors.
  J Biol Chem, 275, 12194-12199.  
10666609 N.Khlebtsova, L.W.Hung, K.Henderson, R.Moon, and T.Earnest (2000).
Expression, crystallization and preliminary X-ray studies of the PDZ domain of Dishevelled protein.
  Acta Crystallogr D Biol Crystallogr, 56, 212-214.  
10824095 P.Wang, Q.Zhang, H.Tochio, J.S.Fan, and M.Zhang (2000).
Formation of a native-like beta-hairpin finger structure of a peptide from the extended PDZ domain of neuronal nitric oxide synthase in aqueous solution.
  Eur J Biochem, 267, 3116-3122.  
11087420 S.H.Gee, S.Quenneville, C.R.Lombardo, and J.Chabot (2000).
Single-amino acid substitutions alter the specificity and affinity of PDZ domains for their ligands.
  Biochemistry, 39, 14638-14646.  
10788497 S.M.Marfatia, O.Byron, G.Campbell, S.C.Liu, and A.H.Chishti (2000).
Human homologue of the Drosophila discs large tumor suppressor protein forms an oligomer in solution. Identification of the self-association site.
  J Biol Chem, 275, 13759-13770.  
11046132 S.Maudsley, A.M.Zamah, N.Rahman, J.T.Blitzer, L.M.Luttrell, R.J.Lefkowitz, and R.A.Hall (2000).
Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity.
  Mol Cell Biol, 20, 8352-8363.  
10698942 U.Rothbächer, M.N.Laurent, M.A.Deardorff, P.S.Klein, K.W.Cho, and S.E.Fraser (2000).
Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis.
  EMBO J, 19, 1010-1022.  
10757875 Y.H.Koh, L.S.Gramates, and V.Budnik (2000).
Drosophila larval neuromuscular junction: molecular components and mechanisms underlying synaptic plasticity.
  Microsc Res Tech, 49, 14-25.  
  10828242 Y.Li-Smerin, and K.J.Swartz (2000).
Localization and molecular determinants of the Hanatoxin receptors on the voltage-sensing domains of a K(+) channel.
  J Gen Physiol, 115, 673-684.  
10500119 A.L.Horwich, E.U.Weber-Ban, and D.Finley (1999).
Chaperone rings in protein folding and degradation.
  Proc Natl Acad Sci U S A, 96, 11033-11040.  
10079096 A.S.Fanning, and J.M.Anderson (1999).
PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane.
  J Clin Invest, 103, 767-772.  
10221915 B.J.Hillier, K.S.Christopherson, K.E.Prehoda, D.S.Bredt, and W.A.Lim (1999).
Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex.
  Science, 284, 812-815.
PDB codes: 1qau 1qav
10610414 B.Margolis, J.P.Borg, S.Straight, and D.Meyer (1999).
The function of PTB domain proteins.
  Kidney Int, 56, 1230-1237.  
9933164 C.D.Thanos, K.E.Goodwill, and J.U.Bowie (1999).
Oligomeric structure of the human EphB2 receptor SAM domain.
  Science, 283, 833-836.
PDB code: 1b4f
9892633 C.Sala, and M.Sheng (1999).
The fyn art of N-methyl-D-aspartate receptor phosphorylation.
  Proc Natl Acad Sci U S A, 96, 335-337.  
10402201 D.B.Arnold, and D.E.Clapham (1999).
Molecular determinants for subcellular localization of PSD-95 with an interacting K+ channel.
  Neuron, 23, 149-157.  
10196227 D.C.Edwards, and G.N.Gill (1999).
Structural features of LIM kinase that control effects on the actin cytoskeleton.
  J Biol Chem, 274, 11352-11361.  
10367883 D.E.Clapham (1999).
Unlocking family secrets: K+ channel transmembrane domains.
  Cell, 97, 547-550.  
9920925 D.Lin, G.D.Gish, Z.Songyang, and T.Pawson (1999).
The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif.
  J Biol Chem, 274, 3726-3733.  
10414323 E.B.Ziff (1999).
Recent excitement in the ionotropic glutamate receptor field.
  Ann N Y Acad Sci, 868, 465-473.  
10542258 H.Kuwahara, N.Araki, K.Makino, N.Masuko, S.Honda, K.Kaibuchi, K.Fukunaga, E.Miyamoto, M.Ogawa, and H.Saya (1999).
A novel NE-dlg/SAP102-associated protein, p51-nedasin, related to the amidohydrolase superfamily, interferes with the association between NE-dlg/SAP102 and N-methyl-D-aspartate receptor.
  J Biol Chem, 274, 32204-32214.  
  10500064 I.Kobayashi, K.Imamura, M.Kubota, S.Ishikawa, M.Yamada, H.Tonoki, M.Okano, W.B.Storch, T.Moriuchi, Y.Sakiyama, and K.Kobayashi (1999).
Identification of an autoimmune enteropathy-related 75-kilodalton antigen.
  Gastroenterology, 117, 823-830.  
10207009 I.Yao, Y.Hata, N.Ide, K.Hirao, M.Deguchi, H.Nishioka, A.Mizoguchi, and Y.Takai (1999).
MAGUIN, a novel neuronal membrane-associated guanylate kinase-interacting protein.
  J Biol Chem, 274, 11889-11896.  
10027300 J.Xia, X.Zhang, J.Staudinger, and R.L.Huganir (1999).
Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1.
  Neuron, 22, 179-187.  
10608883 J.de Rooij, N.M.Boenink, M.van Triest, R.H.Cool, A.Wittinghofer, and J.L.Bos (1999).
PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2.
  J Biol Chem, 274, 38125-38130.  
10400701 K.K.Murthy, K.Clark, Y.Fortin, S.H.Shen, and D.Banville (1999).
ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E.
  J Biol Chem, 274, 20679-20687.  
10488080 K.S.Christopherson, B.J.Hillier, W.A.Lim, and D.S.Bredt (1999).
PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain.
  J Biol Chem, 274, 27467-27473.  
10318831 L.H.Wang, R.G.Kalb, and S.M.Strittmatter (1999).
A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF.
  J Biol Chem, 274, 14137-14146.  
10428961 L.Li, H.Yuan, C.D.Weaver, J.Mao, G.H.Farr, D.J.Sussman, J.Jonkers, D.Kimelman, and D.Wu (1999).
Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.
  EMBO J, 18, 4233-4240.  
9867820 L.Li, H.Yuan, W.Xie, J.Mao, A.M.Caruso, A.McMahon, D.J.Sussman, and D.Wu (1999).
Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells.
  J Biol Chem, 274, 129-134.  
  10567574 M.K.Thomas, K.M.Yao, M.S.Tenser, G.G.Wong, and J.F.Habener (1999).
Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcription.
  Mol Cell Biol, 19, 8492-8504.  
10414325 M.Sheng, and D.T.Pak (1999).
Glutamate receptor anchoring proteins and the molecular organization of excitatory synapses.
  Ann N Y Acad Sci, 868, 483-493.  
  9874689 N.A.Burke, K.Takimoto, D.Li, W.Han, S.C.Watkins, and E.S.Levitan (1999).
Distinct structural requirements for clustering and immobilization of K+ channels by PSD-95.
  J Gen Physiol, 113, 71-80.  
9990060 N.Bannert, A.Avots, M.Baier, E.Serfling, and R.Kurth (1999).
GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes.
  Proc Natl Acad Sci U S A, 96, 1541-1546.  
10026200 N.Masuko, K.Makino, H.Kuwahara, K.Fukunaga, T.Sudo, N.Araki, H.Yamamoto, Y.Yamada, E.Miyamoto, and H.Saya (1999).
Interaction of NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90. A possible regulatory role in molecular clustering at synaptic sites.
  J Biol Chem, 274, 5782-5790.  
10417648 N.Sassoon, J.P.Arié, and J.M.Betton (1999).
PDZ domains determine the native oligomeric structure of the DegP (HtrA) protease.
  Mol Microbiol, 33, 583-589.  
10336672 P.Bassand, A.Bernard, A.Rafiki, D.Gayet, and M.Khrestchatisky (1999).
Differential interaction of the tSXV motifs of the NR1 and NR2A NMDA receptor subunits with PSD-95 and SAP97.
  Eur J Neurosci, 11, 2031-2043.  
  10359609 P.M.Guy, D.A.Kenny, and G.N.Gill (1999).
The PDZ domain of the LIM protein enigma binds to beta-tropomyosin.
  Mol Biol Cell, 10, 1973-1984.  
10220348 P.S.Chockalingam, S.H.Gee, and H.W.Jarrett (1999).
Pleckstrin homology domain 1 of mouse alpha 1-syntrophin binds phosphatidylinositol 4,5-bisphosphate.
  Biochemistry, 38, 5596-5602.  
10391924 Q.Zhou, P.Ruiz-Lozano, M.E.Martone, and J.Chen (1999).
Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C.
  J Biol Chem, 274, 19807-19813.  
10446210 R.A.Hall, R.F.Spurney, R.T.Premont, N.Rahman, J.T.Blitzer, J.A.Pitcher, and R.J.Lefkowitz (1999).
G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction.
  J Biol Chem, 274, 24328-24334.  
10517864 S.D.Dimitratos, D.F.Woods, D.G.Stathakis, and P.J.Bryant (1999).
Signaling pathways are focused at specialized regions of the plasma membrane by scaffolding proteins of the MAGUK family.
  Bioessays, 21, 912-921.  
10414337 S.Srivastava, and E.B.Ziff (1999).
ABP: a novel AMPA receptor binding protein.
  Ann N Y Acad Sci, 868, 561-564.  
10514373 S.W.Lockless, and R.Ranganathan (1999).
Evolutionarily conserved pathways of energetic connectivity in protein families.
  Science, 286, 295-299.  
10551805 X.Xu, Y.Shi, X.Wu, P.Gambetti, D.Sui, and M.Z.Cui (1999).
Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1.
  J Biol Chem, 274, 32543-32546.  
10357812 Y.Nemoto, and P.De Camilli (1999).
Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein.
  EMBO J, 18, 2991-3006.  
9867876 Y.P.Hsueh, and M.Sheng (1999).
Requirement of N-terminal cysteines of PSD-95 for PSD-95 multimerization and ternary complex formation, but not for binding to potassium channel Kv1.4.
  J Biol Chem, 274, 532-536.  
9727012 A.Kato, F.Ozawa, Y.Saitoh, Y.Fukazawa, H.Sugiyama, and K.Inokuchi (1998).
Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors.
  J Biol Chem, 273, 23969-23975.  
9660868 A.R.Cohen, D.F.Woods, S.M.Marfatia, Z.Walther, A.H.Chishti, J.M.Anderson, and D.F.Wood (1998).
Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells.
  J Cell Biol, 142, 129-138.  
9891778 A.Wodarz, and R.Nusse (1998).
Mechanisms of Wnt signaling in development.
  Annu Rev Cell Dev Biol, 14, 59-88.  
9651375 B.E.Snow, R.A.Hall, A.M.Krumins, G.M.Brothers, D.Bouchard, C.A.Brothers, S.Chung, J.Mangion, A.G.Gilman, R.J.Lefkowitz, and D.P.Siderovski (1998).
GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.
  J Biol Chem, 273, 17749-17755.  
9891779 B.R.Stevenson, and B.H.Keon (1998).
The tight junction: morphology to molecules.
  Annu Rev Cell Dev Biol, 14, 89.  
9753322 C.Rongo, C.W.Whitfield, A.Rodal, S.K.Kim, and J.M.Kaplan (1998).
LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia.
  Cell, 94, 751-759.  
9646865 D.Barford, A.K.Das, and M.P.Egloff (1998).
The structure and mechanism of protein phosphatases: insights into catalysis and regulation.
  Annu Rev Biophys Biomol Struct, 27, 133-164.  
9724753 D.Deretic, S.Schmerl, P.A.Hargrave, A.Arendt, and J.H.McDowell (1998).
Regulation of sorting and post-Golgi trafficking of rhodopsin by its C-terminal sequence QVS(A)PA.
  Proc Natl Acad Sci U S A, 95, 10620-10625.  
9546224 D.L.Daniels, A.R.Cohen, J.M.Anderson, and A.T.Brünger (1998).
Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition.
  Nat Struct Biol, 5, 317-325.
PDB code: 1kwa
  9487134 E.Cuppen, H.Gerrits, B.Pepers, B.Wieringa, and W.Hendriks (1998).
PDZ motifs in PTP-BL and RIL bind to internal protein segments in the LIM domain protein RIL.
  Mol Biol Cell, 9, 671-683.  
9430700 E.Kim, S.J.DeMarco, S.M.Marfatia, A.H.Chishti, M.Sheng, and E.E.Strehler (1998).
Plasma membrane Ca2+ ATPase isoform 4b binds to membrane-associated guanylate kinase (MAGUK) proteins via their PDZ (PSD-95/Dlg/ZO-1) domains.
  J Biol Chem, 273, 1591-1595.  
9651370 F.M.Adamski, M.Y.Zhu, F.Bahiraei, and B.H.Shieh (1998).
Interaction of eye protein kinase C and INAD in Drosophila. Localization of binding domains and electrophysiological characterization of a loss of association in transgenic flies.
  J Biol Chem, 273, 17713-17719.  
9837948 G.Lametschwandtner, C.Brocard, M.Fransen, P.Van Veldhoven, J.Berger, and A.Hartig (1998).
The difference in recognition of terminal tripeptides as peroxisomal targeting signal 1 between yeast and human is due to different affinities of their receptor Pex5p to the cognate signal and to residues adjacent to it.
  J Biol Chem, 273, 33635-33643.  
9651675 H.P.Feng, and L.M.Gierasch (1998).
Molecular chaperones: clamps for the Clps?
  Curr Biol, 8, R464-R467.  
9670221 H.V.Wheal, Y.Chen, J.Mitchell, M.Schachner, W.Maerz, H.Wieland, D.Van Rossum, and J.Kirsch (1998).
Molecular mechanisms that underlie structural and functional changes at the postsynaptic membrane during synaptic plasticity.
  Prog Neurobiol, 55, 611-640.  
9593689 J.J.Chen, Y.Hong, E.Rustamzadeh, J.D.Baleja, and E.J.Androphy (1998).
Identification of an alpha helical motif sufficient for association with papillomavirus E6.
  J Biol Chem, 273, 13537-13544.  
9437424 J.Schultz, U.Hoffmüller, G.Krause, J.Ashurst, M.J.Macias, P.Schmieder, J.Schneider-Mergener, and H.Oschkinat (1998).
Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels.
  Nat Struct Biol, 5, 19-24.
PDB code: 2pdz
9568400 K.Broadie (1998).
Forward and reverse genetic approaches to synaptogenesis.
  Curr Opin Neurobiol, 8, 128-138.  
9770488 L.De Vries, X.Lou, G.Zhao, B.Zheng, and M.G.Farquhar (1998).
GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP.
  Proc Natl Acad Sci U S A, 95, 12340-12345.  
9488714 L.Dytrych, D.L.Sherman, C.S.Gillespie, and P.J.Brophy (1998).
Two PDZ domain proteins encoded by the murine periaxin gene are the result of alternative intron retention and are differentially targeted in Schwann cells.
  J Biol Chem, 273, 5794-5800.  
9558457 L.L.Mitic, and J.M.Anderson (1998).
Molecular architecture of tight junctions.
  Annu Rev Physiol, 60, 121-142.  
9651538 M.B.Kennedy (1998).
Signal transduction molecules at the glutamatergic postsynaptic membrane.
  Brain Res Brain Res Rev, 26, 243-257.  
9448462 M.Missler, and T.C.Südhof (1998).
Neurexins: three genes and 1001 products.
  Trends Genet, 14, 20-26.  
9581762 M.Niethammer, J.G.Valtschanoff, T.M.Kapoor, D.W.Allison, R.J.Weinberg, A.M.Craig, and M.Sheng (1998).
CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90.
  Neuron, 20, 693-707.  
9653190 P.E.Burnett, S.Blackshaw, M.M.Lai, I.A.Qureshi, A.F.Burnett, D.M.Sabatini, and S.H.Snyder (1998).
Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton.
  Proc Natl Acad Sci U S A, 95, 8351-8356.  
9699630 P.Mühlhahn, M.Zweckstetter, J.Georgescu, C.Ciosto, C.Renner, M.Lanzendörfer, K.Lang, D.Ambrosius, M.Baier, R.Kurth, and T.A.Holak (1998).
Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site.
  Nat Struct Biol, 5, 682-686.
PDB code: 1i16
9545241 R.van Huizen, K.Miller, D.M.Chen, Y.Li, Z.C.Lai, R.W.Raab, W.S.Stark, R.D.Shortridge, and M.Li (1998).
Two distantly positioned PDZ domains mediate multivalent INAD-phospholipase C interactions essential for G protein-coupled signaling.
  EMBO J, 17, 2285-2297.  
9552154 S.Alberti (1998).
A phosphoinositide-binding sequence is shared by PH domain target molecules--a model for the binding of PH domains to proteins.
  Proteins, 31, 1-9.  
9604925 S.E.Craven, and D.S.Bredt (1998).
PDZ proteins organize synaptic signaling pathways.
  Cell, 93, 495-498.  
9705339 S.H.Gee, S.A.Sekely, C.Lombardo, A.Kurakin, S.C.Froehner, and B.K.Kay (1998).
Cyclic peptides as non-carboxyl-terminal ligands of syntrophin PDZ domains.
  J Biol Chem, 273, 21980-21987.  
9753323 S.M.Kaech, C.W.Whitfield, and S.K.Kim (1998).
The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells.
  Cell, 94, 761-771.  
9459447 S.R.Jaffrey, A.M.Snowman, M.J.Eliasson, N.A.Cohen, and S.H.Snyder (1998).
CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95.
  Neuron, 20, 115-124.  
9830014 S.Sugita, K.Ichtchenko, M.Khvotchev, and T.C.Südhof (1998).
alpha-Latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis.
  J Biol Chem, 273, 32715-32724.  
9582296 T.Toyofuku, M.Yabuki, K.Otsu, T.Kuzuya, M.Hori, and M.Tada (1998).
Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes.
  J Biol Chem, 273, 12725-12731.  
9679151 X.Z.Xu, A.Choudhury, X.Li, and C.Montell (1998).
Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteins.
  J Cell Biol, 142, 545-555.  
9763423 Y.Izumi, T.Hirose, Y.Tamai, S.Hirai, Y.Nagashima, T.Fujimoto, Y.Tabuse, K.J.Kemphues, and S.Ohno (1998).
An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3.
  J Cell Biol, 143, 95.  
9204764 C.P.Ponting, C.Phillips, K.E.Davies, and D.J.Blake (1997).
PDZ domains: targeting signalling molecules to sub-membranous sites.
  Bioessays, 19, 469-479.  
  9041651 C.P.Ponting (1997).
Evidence for PDZ domains in bacteria, yeast, and plants.
  Protein Sci, 6, 464-468.  
9434904 D.Cowburn (1997).
Peptide recognition by PTB and PDZ domains.
  Curr Opin Struct Biol, 7, 835-838.  
9024696 E.Kim, S.Naisbitt, Y.P.Hsueh, A.Rao, A.Rothschild, A.M.Craig, and M.Sheng (1997).
GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules.
  J Cell Biol, 136, 669-678.  
9054412 F.Poulat, P.S.Barbara, M.Desclozeaux, S.Soullier, B.Moniot, N.Bonneaud, B.Boizet, and P.Berta (1997).
The human testis determining factor SRY binds a nuclear factor containing PDZ protein interaction domains.
  J Biol Chem, 272, 7167-7172.  
9094126 H.C.Kornau, and P.H.Seeburg (1997).
Partner selection by PDZ domains.
  Nat Biotechnol, 15, 319.  
9232802 H.C.Kornau, P.H.Seeburg, and M.B.Kennedy (1997).
Interaction of ion channels and receptors with PDZ domain proteins.
  Curr Opin Neurobiol, 7, 368-373.  
9362513 H.Nakanishi, H.Obaishi, A.Satoh, M.Wada, K.Mandai, K.Satoh, H.Nishioka, Y.Matsuura, A.Mizoguchi, and Y.Takai (1997).
Neurabin: a novel neural tissue-specific actin filament-binding protein involved in neurite formation.
  J Cell Biol, 139, 951-961.  
9395497 I.Dobrosotskaya, R.K.Guy, and G.L.James (1997).
MAGI-1, a membrane-associated guanylate kinase with a unique arrangement of protein-protein interaction domains.
  J Biol Chem, 272, 31589-31597.  
9428517 I.Levchenko, C.K.Smith, N.P.Walsh, R.T.Sauer, and T.A.Baker (1997).
PDZ-like domains mediate binding specificity in the Clp/Hsp100 family of chaperones and protease regulatory subunits.
  Cell, 91, 939-947.  
9353304 J.C.Stam, E.E.Sander, F.Michiels, F.N.van Leeuwen, H.E.Kain, R.A.van der Kammen, and J.G.Collard (1997).
Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain.
  J Biol Chem, 272, 28447-28454.  
9391086 J.J.Grootjans, P.Zimmermann, G.Reekmans, A.Smets, G.Degeest, J.Dürr, and G.David (1997).
Syntenin, a PDZ protein that binds syndecan cytoplasmic domains.
  Proc Natl Acad Sci U S A, 94, 13683-13688.  
9241420 J.Kuriyan, and D.Cowburn (1997).
Modular peptide recognition domains in eukaryotic signaling.
  Annu Rev Biophys Biomol Struct, 26, 259-288.  
9108121 J.L.Arriza, S.Eliasof, M.P.Kavanaugh, and S.G.Amara (1997).
Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance.
  Proc Natl Acad Sci U S A, 94, 4155-4160.  
9305890 J.Saras, P.Franzén, P.Aspenström, U.Hellman, L.J.Gonez, and C.H.Heldin (1997).
A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1.
  J Biol Chem, 272, 24333-24338.  
9261095 J.Saras, U.Engström, L.J.Góñez, and C.H.Heldin (1997).
Characterization of the interactions between PDZ domains of the protein-tyrosine phosphatase PTPL1 and the carboxyl-terminal tail of Fas.
  J Biol Chem, 272, 20979-20981.  
9405395 J.Staudinger, J.Lu, and E.N.Olson (1997).
Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha.
  J Biol Chem, 272, 32019-32024.  
9353335 K.Kurashima, F.H.Yu, A.G.Cabado, E.Z.Szabó, S.Grinstein, and J.Orlowski (1997).
Identification of sites required for down-regulation of Na+/H+ exchanger NHE3 activity by cAMP-dependent protein kinase. phosphorylation-dependent and -independent mechanisms.
  J Biol Chem, 272, 28672-28679.  
9061012 K.M.Cadigan, and R.Nusse (1997).
Wnt meeting 1996.
  Biochim Biophys Acta, 1332, R1-R5.  
9214626 K.Willert, M.Brink, A.Wodarz, H.Varmus, and R.Nusse (1997).
Casein kinase 2 associates with and phosphorylates dishevelled.
  EMBO J, 16, 3089-3096.  
9390515 K.Zito, R.D.Fetter, C.S.Goodman, and E.Y.Isacoff (1997).
Synaptic clustering of Fascilin II and Shaker: essential targeting sequences and role of Dlg.
  Neuron, 19, 1007-1016.  
9185308 M.B.Kennedy (1997).
The postsynaptic density at glutamatergic synapses.
  Trends Neurosci, 20, 264-268.  
9278515 M.Irie, Y.Hata, M.Takeuchi, K.Ichtchenko, A.Toyoda, K.Hirao, Y.Takai, T.W.Rosahl, and T.C.Südhof (1997).
Binding of neuroligins to PSD-95.
  Science, 277, 1511-1515.  
9096405 M.J.Eliasson, S.Blackshaw, M.J.Schell, and S.H.Snyder (1997).
Neuronal nitric oxide synthase alternatively spliced forms: prominent functional localizations in the brain.
  Proc Natl Acad Sci U S A, 94, 3396-3401.  
9155014 M.P.Egloff, D.F.Johnson, G.Moorhead, P.T.Cohen, P.Cohen, and D.Barford (1997).
Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1.
  EMBO J, 16, 1876-1887.  
9363678 M.Sheng, and M.Wyszynski (1997).
Ion channel targeting in neurons.
  Bioessays, 19, 847-853.  
9094134 N.L.Stricker, K.S.Christopherson, B.A.Yi, P.J.Schatz, R.W.Raab, G.Dawes, D.E.Bassett, D.S.Bredt, and M.Li (1997).
PDZ domain of neuronal nitric oxide synthase recognizes novel C-terminal peptide sequences.
  Nat Biotechnol, 15, 336-342.  
9275233 P.B.Allen, C.C.Ouimet, and P.Greengard (1997).
Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines.
  Proc Natl Acad Sci U S A, 94, 9956-9961.  
9032075 P.Holliger, and L.Riechmann (1997).
A conserved infection pathway for filamentous bacteriophages is suggested by the structure of the membrane penetration domain of the minor coat protein g3p from phage fd.
  Structure, 5, 265-275.
PDB code: 1fgp
9382826 R.Ranganathan, and E.M.Ross (1997).
PDZ domain proteins: scaffolds for signaling complexes.
  Curr Biol, 7, R770-R773.  
9425351 S.K.Kim (1997).
Polarized signaling: basolateral receptor localization in epithelial cells by PDZ-containing proteins.
  Curr Opin Cell Biol, 9, 853-859.  
9305870 S.M.Marfatia, J.H.Morais-Cabral, A.C.Kim, O.Byron, and A.H.Chishti (1997).
The PDZ domain of human erythrocyte p55 mediates its binding to the cytoplasmic carboxyl terminus of glycophorin C. Analysis of the binding interface by in vitro mutagenesis.
  J Biol Chem, 272, 24191-24197.  
9326658 T.Kiyono, A.Hiraiwa, M.Fujita, Y.Hayashi, T.Akiyama, and M.Ishibashi (1997).
Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein.
  Proc Natl Acad Sci U S A, 94, 11612-11616.  
9405336 T.Pawson, and J.D.Scott (1997).
Signaling through scaffold, anchoring, and adaptor proteins.
  Science, 278, 2075-2080.  
9214388 Y.Huang, J.Jellies, K.M.Johansen, and J.Johansen (1997).
Differential glycosylation of tractin and LeechCAM, two novel Ig superfamily members, regulates neurite extension and fascicle formation.
  J Cell Biol, 138, 143-157.  
9182804 Y.P.Hsueh, E.Kim, and M.Sheng (1997).
Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95.
  Neuron, 18, 803-814.  
9111048 Y.Wang, M.S.Goligorsky, M.Lin, J.N.Wilcox, and P.A.Marsden (1997).
A novel, testis-specific mRNA transcript encoding an NH2-terminal truncated nitric-oxide synthase.
  J Biol Chem, 272, 11392-11401.  
9321393 Z.Zhang, C.H.Lee, V.Mandiyan, J.P.Borg, B.Margolis, J.Schlessinger, and J.Kuriyan (1997).
Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.
  EMBO J, 16, 6141-6150.
PDB codes: 1aqc 1x11
8939589 A.S.Fanning, and J.M.Anderson (1996).
Protein-protein interactions: PDZ domain networks.
  Curr Biol, 6, 1385-1388.  
8805586 D.Cowburn (1996).
Adaptors and integrators.
  Structure, 4, 1005-1008.  
  8887653 J.P.Borg, J.Ooi, E.Levy, and B.Margolis (1996).
The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.
  Mol Cell Biol, 16, 6229-6241.  
8893015 M.Sheng (1996).
PDZs and receptor/channel clustering: rounding up the latest suspects.
  Neuron, 17, 575-578.  
8937823 M.Sheng, and E.Kim (1996).
Ion channel associated proteins.
  Curr Opin Neurobiol, 6, 602-608.  
8893032 N.A.Cohen, J.E.Brenman, S.H.Snyder, and D.S.Bredt (1996).
Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation.
  Neuron, 17, 759-767.  
8752205 N.Perrimon (1996).
Serpentine proteins slither into the wingless and hedgehog fields.
  Cell, 86, 513-516.  
8909548 S.M.Marfatia, J.H.Morais Cabral, L.Lin, C.Hough, P.J.Bryant, L.Stolz, and A.H.Chishti (1996).
Modular organization of the PDZ domains in the human discs-large protein suggests a mechanism for coupling PDZ domain-binding proteins to ATP and the membrane cytoskeleton.
  J Cell Biol, 135, 753-766.  
8893021 V.Budnik, Y.H.Koh, B.Guan, B.Hartmann, C.Hough, D.Woods, and M.Gorczyca (1996).
Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlg.
  Neuron, 17, 627-640.  
9000022 V.Budnik (1996).
Synapse maturation and structural plasticity at Drosophila neuromuscular junctions.
  Curr Opin Neurobiol, 6, 858-867.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.