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BIOMD0000000151 - Singh2006_IL6_Signal_Transduction

 

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Reference Publication
Publication ID: 16752369
Singh A, Jayaraman A, Hahn J.
Modeling regulatory mechanisms in IL-6 signal transduction in hepatocytes.
Biotechnol. Bioeng. 2006 Dec; 95(5): 850-862
Department of Chemical Engineering, Texas A&M University, College Station, Texas 77843-3122, USA.  [more]
Model
Original Model: BIOMD0000000151.xml.origin
Submitter: Harish Dharuri
Submission ID: MODEL9750203466
Submission Date: 14 Sep 2007 07:16:09 UTC
Last Modification Date: 01 Apr 2014 16:06:01 UTC
Creation Date: 31 Aug 2007 15:36:58 UTC
Encoders:  Harish Dharuri
   Vijayalakshmi Chelliah
set #1
bqbiol:hasPart Gene Ontology JAK-STAT cascade
Gene Ontology MAPK cascade
bqbiol:occursIn Brenda Tissue Ontology BTO:0000759
Brenda Tissue Ontology BTO:0000575
set #2
bqbiol:hasTaxon Taxonomy Eukaryota
set #3
bqbiol:hasPart KEGG Pathway mmu04010
KEGG Pathway mmu04630
set #4
bqbiol:hasProperty Mathematical Modelling Ontology MAMO_0000046
set #5
bqmodel:isDerivedFrom BioModels Database Yamada2003_JAK_STAT_pathway
BioModels Database Yamada2003_JAK_STAT_SOCS1_knockout
BioModels Database Schoeberl2002_EGF_MAPK
PubMed 12773095
set #6
bqbiol:isVersionOf Gene Ontology interleukin-6-mediated signaling pathway
Notes

The model reproduces Fig 2 , Fig3A and Fig 3B of the paper. The ODE for x1(gp180) and x3 (gp 130) is wrong and the authors have communicated to the curator that the species ought to have a constant value. There are a few other differences from the paper and these were made in consultation with the authors. Model was successfully tested on MathSBML.


To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.


To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Model
Publication ID: 16752369 Submission Date: 14 Sep 2007 07:16:09 UTC Last Modification Date: 01 Apr 2014 16:06:01 UTC Creation Date: 31 Aug 2007 15:36:58 UTC
Mathematical expressions
Reactions
IL6-gp80 complex formation IL6-gp80 complex dissociation IL6-gp80-gp130-JAK dissociation gp130-JAK complex formation
IL6-gp80-gp130-JAK dimerization IL6-gp80-gp130-JAK dimer dissociation IL6-gp80-gp130-JAK dimer phosphorylation IL6-gp80-gp130-JAK dimer-SHP2 dissociation
IL6-gp80-gp130-JAK -STAT3C complex formation IL6-gp80-gp130-JAK -STAT3C dissociation IL6-gp80-gp130-JAK-STAT3Cast complex formation IL6-gp80-gp130-JAK -SHP2 complex formation
IL6-gp80-gp130-JAK -SOCS3 complex formation IL6-gp80-gp130-JAK -SHP2 dimer dissociation IL6-gp80-gp130-JAK SHP2 Grb2 dissociation IL6-gp80-gp130-JAK-SHP2-Grb2-SOS dissociation
PP1-STAT3Cast dissociation STAT3C dimerization STAT3N transport IL6-gp80-gp130-JAK-SOCS2-STAT3C complex formation
IL6-gp80-gp130-JAK-STAT3C-SOCS3-SHP2 dissociation STAT3C dimerization IL6-gp80-gp130-JAK STAT3Cast complex formation PP1-STAT3C dimer complex formation
STAT3C dimer phosphorylation PP1-STAT3C dimer dissociation Complex formation SHP2 dephosphorylation
IL6-gp80-gp130-JAK-SHP2 phosphorylation STAT3N dimer dissociation PP2-STAT3N dimer complex formation PP2-STAT3N complex formation
STAT3N dimer dissociation PP2-STAT3N dissociation PP2-STAT3N dimer dissociation SOCS3N transcription
SOCS3 mRNA translocation SOCS3 mRNA degradation SOCS3 translation SOCS3 degradation
Complex dissociation SHP2-Grb2 complex formation Grb2-SOS dissociation Complex formation
Complex formation SHP2Grb2-SOS complex formation Complex formation Complex dissociation
Complex dissociation Ras-GTP-Raf complex formation Complex formation SHP2-Grb2-SOS dissociation
Complex formation Raf-Phosp1 dissociation Raf-Ras-GTP dissociation Raf-Phosp1 complex formation
MEK-Raf complex formation MEK-Raf complex dissociation MEK-P-Raf complex formation MEK-P-Phosp2 dissociation
MEK-PP-Phosp2 dissociation MEK-P-Phosp2 complex formation MEK-P-Raf complex dissociation MEK-PP-Phosp2 complex formation
ERK-MEK-PP complex formation ERK-MEK-PP complex dissociation ERK-P-MEK-PP complex dissociation ERK-PP formation
ERK-P-Phosp3 complex dissociation ERK-PP-Phosp3 dissociation ERK-P-Phosp3 formation ERK-PP-Phosp3 formation
Physical entities
Compartments Species
cytosol gp80 IL6-gp80 IL6-gp80-gp130-JAK
gp130-JAK (IL6-gp80-gp130-JAK)2 (IL6-gp80-gp130-JAK)_ast2
(IL6-gp80-gp130-JAK)ast2-JAK SHP2 STAT3C
(IL6-gp80-gp130-JAK)ast2-STAT3C STAT3Cast (IL6-gp80-gp130-JAK)ast2-STAT3Cast
SOCS3 (IL6-gp80-gp130-JAK)ast2-SOCS3 (IL6-gp80-gp130-JAK)ast2-SHP2ast
SHP2ast (IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2 SHP2ast-Grb2
(IL6-gp80-gp130-JAK)ast2-SHP2-Grb2 SHP2ast-Grb2-SOS PP1-STAT3Cast
PP1 STAT3C-STAT3Cast (IL6-gp80-gp130-JAK)ast2-STAT3C-SOCS3-SHP2
STAT3Cast-STAT3Cast Grb2 Ras-GDP
(IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2-SOS-Ras-GDP Ras-GTP Raf
Raf-Ras-GTP Rafast-Phosp1 Rafast
Phosp1 MEK MEK-Rafast
MEK-P MEK-P-Phosp2 Phosp2
MEK-PP ERK ERK-MEK-PP
ERK-P ERK-PP ERK-P-Phosp3
SOS (IL6-gp80-gp130-JAK)ast2-STAT3C-SOCS3 MEK-P-Rafast
(IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2-SOS-Ras-GTP gp130 MEK-PP-Phosp2
JAK Ras-GTPast (IL6-gp80-gp130-JAK)ast2-STAT3C-SHP2
ERK-P-MEK-PP PP1-STAT3Cast-STAT3Cast Grb2-SOS
Phosp3 ERK-PP-Phosp3  
nucleus STAT3N STAT3Nast-STAT3Nast STAT3Nast
PP2 PP2-STAT3Nast-STAT3Nast STAT3N-STAT3Nast
Mrna-SOCS3N PP2-STAT3Nast Mrna-SOCS3C
     
Global parameters
IL6 kf0 kr0 kf1
kr1 kf2 kr2 kf3
kr3 k4 k10 kf5
kr5 k6 kf7 kr7
kf9 kr9 kf21 kr21
kf37 kr37 kf39 kr39
kf32 kr32 k12 kf13
kr13 k17 kf8 kr8
kf11 kr11 k14 Vm
Km kf34 kr34 kf60
kr60 kf15 kr15 kf61
kr61 k16 k18a k18b
k19 k22 k20 k23
kf38 kr38 kf35 kr35
kf24 kr24 kf25 kr25
kf40 kr40 kf26 kr26
kf31 kr31 kf27 kr27
kf28 kr28 kf41 kr41
kf33 kr33 kf30 kr30
k43 kf29 kr29 kf42
kr42 kf44 kr44 k45
kf46 kr46 k51 k49
kf50 kr50 k47 kf48
kr48 kf52 kr52 k53
kr54 kf54 k55 k59
k57 kf58 kr58 kf56
kr56      
Reactions (72)
 
 IL6-gp80 complex formation  → [IL6-gp80];   {gp80}
 
 IL6-gp80 complex dissociation [IL6-gp80] → ;  
 
 IL6-gp80-gp130-JAK dissociation [IL6-gp80-gp130-JAK] → [gp130-JAK] + [IL6-gp80];  
 
 gp130-JAK complex formation [JAK] → [gp130-JAK];   {gp130}
 
 IL6-gp80-gp130-JAK dimerization 2.0 × [IL6-gp80-gp130-JAK] → [(IL6-gp80-gp130-JAK)2];  
 
 IL6-gp80-gp130-JAK dimer dissociation [(IL6-gp80-gp130-JAK)2] → 2.0 × [IL6-gp80-gp130-JAK];  
 
 IL6-gp80-gp130-JAK dimer phosphorylation [(IL6-gp80-gp130-JAK)2] → [(IL6-gp80-gp130-JAK)_ast2];  
 
 IL6-gp80-gp130-JAK dimer-SHP2 dissociation [(IL6-gp80-gp130-JAK)ast2-JAK] → [SHP2] + [(IL6-gp80-gp130-JAK)2];  
 
 IL6-gp80-gp130-JAK -STAT3C complex formation [STAT3C] + [(IL6-gp80-gp130-JAK)_ast2] → [(IL6-gp80-gp130-JAK)ast2-STAT3C];  
 
 IL6-gp80-gp130-JAK -STAT3C dissociation [(IL6-gp80-gp130-JAK)ast2-STAT3C] → [STAT3Cast] + [(IL6-gp80-gp130-JAK)_ast2];  
 
 IL6-gp80-gp130-JAK-STAT3Cast complex formation [STAT3Cast] + [(IL6-gp80-gp130-JAK)_ast2] ↔ [(IL6-gp80-gp130-JAK)ast2-STAT3Cast];  
 
 IL6-gp80-gp130-JAK -SHP2 complex formation [SHP2] + [(IL6-gp80-gp130-JAK)_ast2] ↔ [(IL6-gp80-gp130-JAK)ast2-JAK];  
 
 IL6-gp80-gp130-JAK -SOCS3 complex formation [SOCS3] + [(IL6-gp80-gp130-JAK)_ast2] ↔ [(IL6-gp80-gp130-JAK)ast2-SOCS3];  
 
 IL6-gp80-gp130-JAK -SHP2 dimer dissociation [(IL6-gp80-gp130-JAK)ast2-SHP2ast] ↔ [SHP2ast] + [(IL6-gp80-gp130-JAK)_ast2];  
 
 IL6-gp80-gp130-JAK SHP2 Grb2 dissociation [(IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2] ↔ [SHP2ast-Grb2] + [(IL6-gp80-gp130-JAK)_ast2];  
 
 IL6-gp80-gp130-JAK-SHP2-Grb2-SOS dissociation [(IL6-gp80-gp130-JAK)ast2-SHP2-Grb2] ↔ [SHP2ast-Grb2-SOS] + [(IL6-gp80-gp130-JAK)_ast2];  
 
 PP1-STAT3Cast dissociation [PP1-STAT3Cast] → [PP1] + [STAT3C];  
 
 STAT3C dimerization [STAT3Cast] + [STAT3C] ↔ [STAT3C-STAT3Cast];  
 
 STAT3N transport [STAT3N] → [STAT3C];  
 
 IL6-gp80-gp130-JAK-SOCS2-STAT3C complex formation [(IL6-gp80-gp130-JAK)ast2-SOCS3] + [STAT3C] ↔ [(IL6-gp80-gp130-JAK)ast2-STAT3C-SOCS3];  
 
 IL6-gp80-gp130-JAK-STAT3C-SOCS3-SHP2 dissociation [(IL6-gp80-gp130-JAK)ast2-STAT3C-SOCS3-SHP2] → [SOCS3] + [SHP2] + [STAT3C] + [(IL6-gp80-gp130-JAK)2];  
 
 STAT3C dimerization [STAT3Cast] ↔ 0.5 × [STAT3Cast-STAT3Cast];  
 
 IL6-gp80-gp130-JAK STAT3Cast complex formation [PP1] + [STAT3Cast] ↔ [PP1-STAT3Cast];  
 
 PP1-STAT3C dimer complex formation [PP1] + [STAT3Cast-STAT3Cast] ↔ [PP1-STAT3Cast-STAT3Cast];  
 
 STAT3C dimer phosphorylation [STAT3Cast-STAT3Cast] → [STAT3Nast-STAT3Nast];  
 
 PP1-STAT3C dimer dissociation [PP1-STAT3Cast-STAT3Cast] → [PP1] + [STAT3C-STAT3Cast];  
 
 Complex formation [(IL6-gp80-gp130-JAK)ast2-STAT3C-SOCS3] + [SHP2] → [(IL6-gp80-gp130-JAK)ast2-STAT3C-SOCS3-SHP2];  
 
 SHP2 dephosphorylation [SHP2ast] → [SHP2];  
 
 IL6-gp80-gp130-JAK-SHP2 phosphorylation [(IL6-gp80-gp130-JAK)ast2-JAK] ↔ [(IL6-gp80-gp130-JAK)ast2-SHP2ast];  
 
 STAT3N dimer dissociation [STAT3Nast-STAT3Nast] ↔ 2.0 × [STAT3Nast];  
 
 PP2-STAT3N dimer complex formation [PP2] + [STAT3Nast-STAT3Nast] ↔ [PP2-STAT3Nast-STAT3Nast];  
 
 PP2-STAT3N complex formation [PP2] + [STAT3Nast] ↔ [PP2-STAT3Nast];  
 
 STAT3N dimer dissociation [STAT3N-STAT3Nast] ↔ [STAT3N] + [STAT3Nast];  
 
 PP2-STAT3N dissociation [PP2-STAT3Nast] → [PP2] + [STAT3N];  
 
 PP2-STAT3N dimer dissociation [PP2-STAT3Nast-STAT3Nast] → [STAT3N-STAT3Nast] + [PP2];  
 
 SOCS3N transcription  → [Mrna-SOCS3N];   {STAT3Nast-STAT3Nast}
 
 SOCS3 mRNA translocation [Mrna-SOCS3N] → [Mrna-SOCS3C];  
 
 SOCS3 mRNA degradation [Mrna-SOCS3C] → ;  
 
 SOCS3 translation  → [SOCS3];   {Mrna-SOCS3C}
 
 SOCS3 degradation [SOCS3] → ;  
 
 Complex dissociation [(IL6-gp80-gp130-JAK)ast2-STAT3C-SOCS3-SHP2] → [(IL6-gp80-gp130-JAK)ast2-STAT3C-SHP2] + [SOCS3];  
 
 SHP2-Grb2 complex formation [SHP2ast] + [Grb2] ↔ [SHP2ast-Grb2];  
 
 Grb2-SOS dissociation [Grb2-SOS] ↔ [SOS] + [Grb2];  
 
 Complex formation [(IL6-gp80-gp130-JAK)ast2-SHP2ast] + [Grb2] ↔ [(IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2];  
 
 Complex formation [(IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2] + [SOS] ↔ [(IL6-gp80-gp130-JAK)ast2-SHP2-Grb2];  
 
 SHP2Grb2-SOS complex formation [SHP2ast-Grb2] + [SOS] ↔ [SHP2ast-Grb2-SOS];  
 
 Complex formation [(IL6-gp80-gp130-JAK)ast2-SHP2-Grb2] + [Ras-GDP] ↔ [(IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2-SOS-Ras-GDP];  
 
 Complex dissociation [(IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2-SOS-Ras-GTP] ↔ [(IL6-gp80-gp130-JAK)ast2-SHP2-Grb2] + [Ras-GDP];  
 
 Complex dissociation [(IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2-SOS-Ras-GDP] ↔ [(IL6-gp80-gp130-JAK)ast2-SHP2-Grb2] + [Ras-GTP];  
 
 Ras-GTP-Raf complex formation [Raf] + [Ras-GTP] ↔ [Raf-Ras-GTP];  
 
 Complex formation [(IL6-gp80-gp130-JAK)ast2-SHP2ast] + [Grb2-SOS] ↔ [(IL6-gp80-gp130-JAK)ast2-SHP2-Grb2];  
 
 SHP2-Grb2-SOS dissociation [SHP2ast-Grb2-SOS] ↔ [SHP2ast] + [Grb2-SOS];  
 
 Complex formation [Ras-GTPast] + [(IL6-gp80-gp130-JAK)ast2-SHP2-Grb2] ↔ [(IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2-SOS-Ras-GTP];  
 
 Raf-Phosp1 dissociation [Rafast-Phosp1] → [Raf] + [Phosp1];  
 
 Raf-Ras-GTP dissociation [Raf-Ras-GTP] ↔ [Rafast] + [Ras-GTPast];  
 
 Raf-Phosp1 complex formation [Rafast] + [Phosp1] ↔ [Rafast-Phosp1];  
 
 MEK-Raf complex formation [MEK] + [Rafast] ↔ [MEK-Rafast];  
 
 MEK-Raf complex dissociation [MEK-Rafast] → [MEK-P] + [Rafast];  
 
 MEK-P-Raf complex formation [MEK-P] + [Rafast] ↔ [MEK-P-Rafast];  
 
 MEK-P-Phosp2 dissociation [MEK-P-Phosp2] → [Phosp2] + [MEK];  
 
 MEK-PP-Phosp2 dissociation [MEK-PP-Phosp2] → [Phosp2] + [MEK-P];  
 
 MEK-P-Phosp2 complex formation [Phosp2] + [MEK-P] ↔ [MEK-P-Phosp2];  
 
 MEK-P-Raf complex dissociation [MEK-P-Rafast] → [Rafast] + [MEK-PP];  
 
 MEK-PP-Phosp2 complex formation [Phosp2] + [MEK-PP] ↔ [MEK-PP-Phosp2];  
 
 ERK-MEK-PP complex formation [ERK] + [MEK-PP] ↔ [ERK-MEK-PP];  
 
 ERK-MEK-PP complex dissociation [ERK-MEK-PP] → [ERK-P] + [MEK-PP];  
 
 ERK-P-MEK-PP complex dissociation [ERK-P-MEK-PP] ↔ [ERK-P] + [MEK-PP];  
 
 ERK-PP formation [ERK-P-MEK-PP] → [ERK-PP] + [MEK-PP];  
 
 ERK-P-Phosp3 complex dissociation [ERK-P-Phosp3] → [Phosp3] + [ERK];  
 
 ERK-PP-Phosp3 dissociation [ERK-PP-Phosp3] → [Phosp3] + [ERK-P];  
 
 ERK-P-Phosp3 formation [Phosp3] + [ERK-P] ↔ [ERK-P-Phosp3];  
 
 ERK-PP-Phosp3 formation [Phosp3] + [ERK-PP] ↔ [ERK-PP-Phosp3];  
 
 cytosol Spatial dimensions: 3.0  Compartment size: 1.0
 
 gp80
Compartment: cytosol
Initial concentration: 8.0
Constant
 
 IL6-gp80
Compartment: cytosol
Initial concentration: 0.0
 
 IL6-gp80-gp130-JAK
Compartment: cytosol
Initial concentration: 0.0
 
 gp130-JAK
Compartment: cytosol
Initial concentration: 0.0
 
 (IL6-gp80-gp130-JAK)2
Compartment: cytosol
Initial concentration: 0.0
 
 (IL6-gp80-gp130-JAK)_ast2
Compartment: cytosol
Initial concentration: 0.0
 
 (IL6-gp80-gp130-JAK)ast2-JAK
Compartment: cytosol
Initial concentration: 0.0
 
 SHP2
Compartment: cytosol
Initial concentration: 100.0
 
 STAT3C
Compartment: cytosol
Initial concentration: 1000.0
 
 (IL6-gp80-gp130-JAK)ast2-STAT3C
Compartment: cytosol
Initial concentration: 0.0
 
 STAT3Cast
Compartment: cytosol
Initial concentration: 0.0
 
 (IL6-gp80-gp130-JAK)ast2-STAT3Cast
Compartment: cytosol
Initial concentration: 0.0
 
 SOCS3
Compartment: cytosol
Initial concentration: 0.0
 
 (IL6-gp80-gp130-JAK)ast2-SOCS3
Compartment: cytosol
Initial concentration: 0.0
 
 (IL6-gp80-gp130-JAK)ast2-SHP2ast
Compartment: cytosol
Initial concentration: 0.0
 
 SHP2ast
Compartment: cytosol
Initial concentration: 0.0
 
 (IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2
Compartment: cytosol
Initial concentration: 0.0
 
 SHP2ast-Grb2
Compartment: cytosol
Initial concentration: 0.0
 
 (IL6-gp80-gp130-JAK)ast2-SHP2-Grb2
Compartment: cytosol
Initial concentration: 0.0
 
 SHP2ast-Grb2-SOS
Compartment: cytosol
Initial concentration: 0.0
 
 PP1-STAT3Cast
Compartment: cytosol
Initial concentration: 0.0
 
   PP1
Compartment: cytosol
Initial concentration: 50.0
 
 STAT3C-STAT3Cast
Compartment: cytosol
Initial concentration: 0.0
 
 (IL6-gp80-gp130-JAK)ast2-STAT3C-SOCS3-SHP2
Compartment: cytosol
Initial concentration: 0.0
 
 STAT3Cast-STAT3Cast
Compartment: cytosol
Initial concentration: 0.0
 
 Grb2
Compartment: cytosol
Initial concentration: 85.0
 
 Ras-GDP
Compartment: cytosol
Initial concentration: 19000.0
 
 (IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2-SOS-Ras-GDP
Compartment: cytosol
Initial concentration: 0.0
 
 Ras-GTP
Compartment: cytosol
Initial concentration: 0.0
 
 Raf
Compartment: cytosol
Initial concentration: 67.0
 
 Raf-Ras-GTP
Compartment: cytosol
Initial concentration: 0.0
 
 Rafast-Phosp1
Compartment: cytosol
Initial concentration: 0.0
 
 Rafast
Compartment: cytosol
Initial concentration: 0.0
 
   Phosp1
Compartment: cytosol
Initial concentration: 67.0
 
 MEK
Compartment: cytosol
Initial concentration: 41667.0
 
 MEK-Rafast
Compartment: cytosol
Initial concentration: 0.0
 
 MEK-P
Compartment: cytosol
Initial concentration: 0.0
 
 MEK-P-Phosp2
Compartment: cytosol
Initial concentration: 0.0
 
   Phosp2
Compartment: cytosol
Initial concentration: 67.0
 
 MEK-PP
Compartment: cytosol
Initial concentration: 0.0
 
 ERK
Compartment: cytosol
Initial concentration: 35000.0
 
 ERK-MEK-PP
Compartment: cytosol
Initial concentration: 0.0
 
 ERK-P
Compartment: cytosol
Initial concentration: 0.0
 
 ERK-PP
Compartment: cytosol
Initial concentration: 0.0
 
 ERK-P-Phosp3
Compartment: cytosol
Initial concentration: 0.0
 
 SOS
Compartment: cytosol
Initial concentration: 34.0
 
 (IL6-gp80-gp130-JAK)ast2-STAT3C-SOCS3
Compartment: cytosol
Initial concentration: 0.0
 
 MEK-P-Rafast
Compartment: cytosol
Initial concentration: 0.0
 
 (IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2-SOS-Ras-GTP
Compartment: cytosol
Initial concentration: 0.0
 
 gp130
Compartment: cytosol
Initial concentration: 0.8
Constant
 
 MEK-PP-Phosp2
Compartment: cytosol
Initial concentration: 0.0
 
 JAK
Compartment: cytosol
Initial concentration: 12.0
 
 Ras-GTPast
Compartment: cytosol
Initial concentration: 0.0
 
 (IL6-gp80-gp130-JAK)ast2-STAT3C-SHP2
Compartment: cytosol
Initial concentration: 0.0
 
 ERK-P-MEK-PP
Compartment: cytosol
Initial concentration: 0.0
 
 PP1-STAT3Cast-STAT3Cast
Compartment: cytosol
Initial concentration: 0.0
 
 Grb2-SOS
Compartment: cytosol
Initial concentration: 0.0
 
   Phosp3
Compartment: cytosol
Initial concentration: 16667.0
 
 ERK-PP-Phosp3
Compartment: cytosol
Initial concentration: 0.0
 
 nucleus Spatial dimensions: 3.0  Compartment size: 1.0
 
 STAT3N
Compartment: nucleus
Initial concentration: 0.0
 
 STAT3Nast-STAT3Nast
Compartment: nucleus
Initial concentration: 0.0
 
 STAT3Nast
Compartment: nucleus
Initial concentration: 0.0
 
   PP2
Compartment: nucleus
Initial concentration: 60.0
 
 PP2-STAT3Nast-STAT3Nast
Compartment: nucleus
Initial concentration: 0.0
 
 STAT3N-STAT3Nast
Compartment: nucleus
Initial concentration: 0.0
 
   Mrna-SOCS3N
Compartment: nucleus
Initial concentration: 0.0
 
 PP2-STAT3Nast
Compartment: nucleus
Initial concentration: 0.0
 
   Mrna-SOCS3C
Compartment: nucleus
Initial concentration: 0.0
 
Global Parameters (105)
 
   IL6
Value: 0.38
Constant
 
   kf0
Value: 0.1
Constant
 
   kr0
Value: 0.05
Constant
 
   kf1
Value: 0.1
Constant
 
   kr1
Value: 0.05
Constant
 
   kf2
Value: 0.02
Constant
 
   kr2
Value: 0.02
Constant
 
   kf3
Value: 0.04
Constant
 
   kr3
Value: 0.2
Constant
 
   k4
Value: 0.0050
Constant
 
   k10
Value: 0.0030
Constant
 
   kf5
Value: 0.0080
Constant
 
   kr5
Value: 0.8
Constant
 
   k6
Value: 0.4
Constant
 
   kf7
Value: 0.0050
Constant
 
   kr7
Value: 0.5
Constant
 
   kf9
Value: 0.0010
Constant
 
   kr9
Value: 0.2
Constant
 
   kf21
Value: 0.02
Constant
 
   kr21
Value: 0.1
Constant
 
   kf37
Value: 0.3
Constant
 
   kr37
Value: 9.0E-4
Constant
 
   kf39
Value: 0.3
Constant
 
   kr39
Value: 9.0E-4
Constant
 
   kf32
Value: 0.1
Constant
 
   kr32
Value: 2.45E-4
Constant
 
   k12
Value: 0.0030
Constant
 
   kf13
Value: 2.0E-7
Constant
 
   kr13
Value: 0.2
Constant
 
   k17
Value: 0.05
Constant
 
   kf8
Value: 0.02
Constant
 
   kr8
Value: 0.1
Constant
 
   kf11
Value: 0.0010
Constant
 
   kr11
Value: 0.2
Constant
 
   k14
Value: 0.0050
Constant
 
   Vm
Value: 1.7
Constant
 
   Km
Value: 340.0
Constant
 
   kf34
Value: 6.0
Constant
 
   kr34
Value: 0.06
Constant
 
   kf60
Value: 0.5
Constant
 
   kr60
Value: 0.0050
Constant
 
   kf15
Value: 0.0010
Constant
 
   kr15
Value: 0.2
Constant
 
   kf61
Value: 0.2
Constant
 
   kr61
Value: 2.0E-7
Constant
 
   k16
Value: 0.0050
Constant
 
   k18a
Value: 0.01
Constant
 
   k18b
Value: 400.0
Constant
 
   k19
Value: 0.0010
Constant
 
   k22
Value: 5.0E-4
Constant
 
   k20
Value: 0.01
Constant
 
   k23
Value: 5.0E-4
Constant
 
   kf38
Value: 0.01
Constant
 
   kr38
Value: 0.55
Constant
 
   kf35
Value: 0.0015
Constant
 
   kr35
Value: 0.0045
Constant
 
   kf24
Value: 0.01
Constant
 
   kr24
Value: 0.55
Constant
 
   kf25
Value: 0.01
Constant
 
   kr25
Value: 0.0214
Constant
 
   kf40
Value: 0.03
Constant
 
   kr40
Value: 0.064
Constant
 
   kf26
Value: 0.015
Constant
 
   kr26
Value: 1.3
Constant
 
   kf31
Value: 0.023
Constant
 
   kr31
Value: 2.2E-4
Constant
 
   kf27
Value: 0.5
Constant
 
   kr27
Value: 1.0E-4
Constant
 
   kf28
Value: 0.0010
Constant
 
   kr28
Value: 0.0053
Constant
 
   kf41
Value: 0.03
Constant
 
   kr41
Value: 0.0429
Constant
 
   kf33
Value: 0.3
Constant
 
   kr33
Value: 0.021
Constant
 
   kf30
Value: 0.0079
Constant
 
   kr30
Value: 0.4
Constant
 
   k43
Value: 1.0
Constant
 
   kf29
Value: 1.0
Constant
 
   kr29
Value: 7.0E-4
Constant
 
   kf42
Value: 0.0717
Constant
 
   kr42
Value: 0.2
Constant
 
   kf44
Value: 0.011
Constant
 
   kr44
Value: 0.001833
Constant
 
   k45
Value: 3.5
Constant
 
   kf46
Value: 0.011
Constant
 
   kr46
Value: 0.001833
Constant
 
   k51
Value: 0.058
Constant
 
   k49
Value: 0.058
Constant
 
   kf50
Value: 2.5E-4
Constant
 
   kr50
Value: 0.5
Constant
 
   k47
Value: 2.9
Constant
 
   kf48
Value: 0.0143
Constant
 
   kr48
Value: 0.8
Constant
 
   kf52
Value: 1.1E-4
Constant
 
   kr52
Value: 0.033
Constant
 
   k53
Value: 16.0
Constant
 
   kr54
Value: 0.033
Constant
 
   kf54
Value: 1.1E-4
Constant
 
   k55
Value: 6.7
Constant
 
   k59
Value: 0.3
Constant
 
   k57
Value: 0.27
Constant
 
   kf58
Value: 0.0050
Constant
 
   kr58
Value: 0.5
Constant
 
   kf56
Value: 0.014
Constant
 
   kr56
Value: 0.6
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000151

Curator's comment: (updated: 05 Apr 2011 16:10:31 BST)

The plots correspond to Fig 2 and 3 of the reference publication. Results were obtained from MathSBML.

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