Interaction

The Interaction section provides information about interactions with other molecules as well as details of protein complexes of which the protein is a member (Figure 31).

• The ‘Subunit structure’ subsection describes the quaternary structure of a protein as well as giving a free-text representation of interactions with other proteins or protein complexes.
• The ‘Binary interactions’ subsection provides a quality-filtered set of binary interactions from the IMEx databases via the IntAct molecular interaction database. These are presented in a visual matrix, which shows blue dots for interactions. The matrix shows interactions between the protein and its interactors as well as those between the interactors. The depth of the blue colour shows the number of experiments providing evidence for the interaction. The interactions can be filtered by subcellular location or disease involvement of one of the interactors.
• The Complex Viewer allows you to visualise protein complexes which have been curated in the Complex Portal, an encyclopaedic resource of macromolecular complexes from a number of key model organisms. You can examine the internal topology and stoichiometry of a complex when this is known, and you can click on a node to see binding domains.
• The ‘Protein-protein interaction databases’ section contains links to a number of specialised protein-protein interaction databases where you can find more detailed interaction information.

Figure 31 Interaction section from Saccharomyces cerevisiae Elongator complex protein 2, UniProtKB entry P42935, showing ‘Binary interactions’, the Complex Viewer and ‘Protein-protein interaction databases’.