Interaction

The Interaction section of a UniProtKB entry provides information on the interaction with other molecules protein make, and the protein complexes they may be a subunit of:

• The ‘Subunit structure’ section describes the quaternary structure of a protein as well as giving a free-text representation of interactions with other proteins or protein complexes
• The ‘Binary interactions’ section provides a quality-filtered set of binary interactions automatically derived from the IMEx databases via the IntAct molecular interaction database. These are presented in a visual matrix, which shows blue dots for interactions. The matrix shows interactions between the protein and its interactors as well as those between the interactors. The depth of the blue colour shows the number of experiments providing evidence for the interaction. The interactions can be filtered by subcellular location or disease involvement of one of the interactors
• The ‘GO – Molecular function’ section shows any interaction-related Gene Ontology (GO) terms available

The ‘Protein-protein interaction databases’ section contains links to a number of specialised protein-protein interaction databases where you can find more detailed interaction information. These include the Complex Portal which describes the role of the protein in any protein complex of which it is a member (Figure 28)