Summary

Reactome pathways

• Reactome is a free, curated pathway database that represents human biological processes as interconnected molecular events or ‘reactions’
• Reactions are the ‘steps’ in pathways and can be any molecular event in biology
• Pathways are organised hierarchically and often have sub-pathways. At highest hierarchical level pathways are represented in an Overview. At intermediate and lower levels they are often represented as interactive illustrations and detailed Pathway Diagrams

You can learn more in Reactome: Exploring biological pathways

Reactome tools

• Reactome includes tools for analysing the pathway context of your data, mapping expression or other quantitative data onto pathways or extending pathways with interactions from external databases
• Using Reactome tools you can:
  
  
  • Perform various types of pathway analyses on qualitative and quantitative datasets including over-representation, gene-set analysis and topology analysis
  • Overlay your gene expression data onto Reactome pathways to assess the likelihood that the pathway is relevant to your study
  • Compare curated human pathways in Reactome with computationally inferred pathways in other species
  • Investigate how pathways may differ in different tissue types based on protein expression
  • Explore pathways that are enriched in different diseases based on associated genes
• Reactome pathways can be extended using interactive tools that graphically represent interactors from IntAct, other interaction databases, or your own interactions data