Access via the website

The website is the most straightforward option. You can search for a protein using the search bar on the homepage, which accepts a variety of common biological identifiers:

• Protein name: You can use the protein’s full name (e.g., Tumour protein p53).
• Gene name: Search for a protein using its gene name (e.g., TP53).
• UniProt accession: This is the most common and recommended way to search for a specific entry (e.g., P04637).
• Source organism name: Search for all proteins from a specific organism (e.g., E. coli).
• Amino acid sequence: If you only have a protein sequence, you can paste it into the search bar. The database will perform a similarity search using BLAST, which may take up to 10 minutes to complete. The query must be at least 20 amino acids long, and only standard residues are accepted.

You can also refine your search results using filters for organisms, reference proteomes and/or review status (e.g., Reviewed/Unreviewed) to more effectively identify proteins of interest.

To filter your search results based on the predicted Local Distance Difference Test (pLDDT) score, you can use the interactive slider. Simply adjust the slider handles to set your desired minimum and maximum pLDDT score range.

Once you have set the range, click the ‘Apply score range’ button to filter the results. This will refresh the page to show only the protein structures that fall within your specified quality range.

Try it yourself

You can use the embedded AlphaFold Database below to search for your protein of interest.