Travel to high altitude: ArrayExpress

Machu Picchu, Everest Basecamp, Mont Blanc and the Cerro Torre in Argentina – beautiful, once-in-a-lifetime destinations. For most people, visiting these places will require a period of acclimatisation to avoid altitude sickness.

Some populations, for example people living in the Argentinean Andes, have enviable adaptations to their local environment that urban people can only dream of. One of these adaptations is to live at too low oxygen levels at high altitudes.

As with many other population-specific traits, it has long been suspected that adaptation to high altitudes is linked to positively-selected SNPs⁴.

Try solving the following challenge using ArrayExpress in BioStudies. Give it a go yourself before looking at the solution at the bottom of this page. Turn the card if you need a hint!

Solution

Explore the following BioStudies page to find out how you can solve this challenge.

About ArrayExpress

ArrayExpress was a database for archiving functional genomics data. Array Express data can now be found in the data resource BioStudies. You’ll find data on transcriptomics (expression profiling), epigenetics (e.g. ChIP-seq, bisulphite-seq, ATAC-seq) and genomics (e.g. genotyping/SNP-typing). All data come from microarray and/or Next-Generation Sequencing (NGS) technologies. Data are either directly submitted to ArrayExpress (often pre-published) via the submission tool Annotare, or imported from a similar repository called Gene Expression Omnibus at NCBI via an automatic pipeline.

Learn more in ArrayExpress in BioStudies: Quick tour.