Computer models are increasingly used by researchers as well as the pharmaceutical industry to investigate disease initiation, progression and therapy. Modelling of biochemical pathways deregulated in disease condition offers mechanistic insights into the pathology; helps to elucidate mechanisms behind dug action and predict dose required for treatment and thereby greatly facilitates fundamental research and drug discovery. Such modelling requires a background in both molecular biology and mathematics. 

The four days workshop will train researchers from life science and mathematics to communicate and work together to learn to build and analyse computer models using user-friendly open-source software. The workshop will be jointly organised by EBI and Indian Institute of Technology Madras (IITM; https://www.iitm.ac.in/), more specifically, BioModels team from EBI along with  Initiative for Biological Systems Engineering (IBSE; https://ibse.iitm.ac.in/) and Robert Bosch Centre for Data Sciences and Artificial Intelligence (RBC-DSAI; https://rbcdsai.iitm.ac.in/) from IITM. This national-level workshop will be organised locally at IITM. Various modelling approaches and tools will be introduced to the participants. They will explore a few of the disease-specific computer models from a recent publication, freely available in BioModels repository (//www.ebi.ac.uk/biomodels/).

Other EBI resources including Reactome, IntAct, OmicsDI, PRIDE, ExpressionAtlas will be introduced to the participants  BioModels team will lead the training on kinetic modelling of signalling pathways, curation and annotation of mathematical models as well as standards in modelling (SBML, SED-ML, etc). IITM/IBSE team will partner in the training on kinetic modelling approaches, and also introduce other paradigms such as constraint-based modelling (e.g. Flux Balance Analysis (FBA)) for the analysis of metabolic pathways.   

An essential agenda in the meeting will be group projects where participants from both experimental and theoretical background would work to getter to curate mathematical models and submit them to the BioModels repository. This workshop will allow EBI to partner with IITM to share expertise on kinetic modelling and gain expertise on the curation of non-kinetic models in BioModels repository. Furthermore, this join workshop would be used as an opportunity for long term partnership with IITM to establish training for EBI resources in India, explore the possibility of joint data curation engagement and scientific collaboration.

Who is this course for?

Participants from both experimental and theoretical backgrounds would benefit from this workshop.

What will I learn?

Learning outcomes

After this workshop you should be able to explain and construct mathematical models for biochemical pathways.

Trainers