PDBsum entry 9u4w

Membrane protein

PDB id: 9u4w

Contents

Protein chains

219 a.a.

338 a.a.

11 a.a.

57 a.a.

271 a.a.

232 a.a.

PDB id:

9u4w

Name:

Membrane protein

Title:

Cryo-em structure of pig gnrhr bound with mammal gnrh

Structure:

Guanine nucleotide-binding protein g(q) subunit alpha-1. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Gonadoliberin-1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Synthetic: yes. Gene: gng2. Homo sapiens, sus scrofa.

Authors:

S.Shen,H.E.Xu

Key ref:

S.Shen and h.e.xu Cryo-Em structures of gnrhr: foundations for next-Gen therapeutics. To be published, . PubMed id: 40523184

Date:

20-Mar-25 Release date: 11-Jun-25

Protein chain

No UniProt id for this chain

Struc: 219 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P01148  (GON1_HUMAN) -  Progonadoliberin-1 from Homo sapiens

Seq: 92 a.a.

Struc: 11 a.a.*

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

P49922  (GNRHR_PIG) -  Gonadotropin-releasing hormone receptor from Sus scrofa

Seq: 328 a.a.

Struc: 271 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)