PDBsum entry 9rpy

Transferase

PDB id: 9rpy

Contents

Protein chains

137 a.a.

Ligands

UIS

EDO

DMS

Metals

_MN ×2

Waters ×455

PDB id:

9rpy

Name:

Transferase

Title:

Fragment screening of fosakp, cryo structure in complex with fragment f2x-entry b07

Structure:

Fosa family fosfomycin resistance glutathione transferase. Chain: a, b. Synonym: fosa_9_nz_aczd01000244,fosfomycin resistance protein fosa. Engineered: yes

Source:

Klebsiella pneumoniae. Organism_taxid: 573. Gene: fosa, banra_04523, dm078_10090, dw286_28140, e1814_00065, eao17_17205, gjj08_023570, gnf00_20975, h3g96_004055, jmz77_23230, samea3499874_02877, samea3649591_01987, samea3720909_04483. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.16Å R-factor: 0.142 R-free: 0.162

Authors:

S.Guenther,M.Galchenkova,P.Fischer,P.Y.A.Reinke,S.Falke,S.Thekku Veedu,A.C.Rodrigues,J.Senst,A.Meents

Key ref:

S.Gunther et al. (2025). Room-Temperature X-Ray fragment screening with serial crystallography.. Nat commun, 16, 9089. PubMed id: 41083451 DOI: 10.1038/S41467-025-64918-6

Date:

25-Jun-25 Release date: 15-Oct-25

Protein chains

A0A086IRG1  () -  FosA family fosfomycin resistance glutathione transferase from Klebsiella pneumoniae

Seq: 139 a.a.

Struc: 137 a.a.

Enzyme reactions

• Enzyme class: E.C.2.5.1.18 - glutathione transferase.
• Reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site