PDBsum entry 9m54

Membrane protein/immune system

PDB id: 9m54

Contents

Protein chains

293 a.a.

343 a.a.

59 a.a.

228 a.a.

232 a.a.

Ligands

PRO-ASN-LEU-PRO-GLN-ARG-PHE-NH2

PDB id:

9m54

Name:

Membrane protein/immune system

Title:

Cryo-em structure of neuropeptide ff receptor 2 complex with npvf

Structure:

Neuropeptide ff receptor 2. Chain: r. Synonym: g-protein coupled receptor 74,g-protein coupled receptor hlwar77,neuropeptide g-protein coupled receptor. Engineered: yes. Neuropeptide vf. Chain: l. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: npffr2, gpr74, npff2, npgpr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Synthetic construct. Organism_taxid: 32630.

Authors:

B.X.Pan,Y.Jiang,X.Z.Li

Key ref:

X.Z.Li et al. Structural basis of peptide recognition and modulatio neuropeptide ff receptors. To be published, . PubMed id: 40839429

Date:

05-Mar-25 Release date: 23-Jul-25

Protein chain

Q9Y5X5  (NPFF2_HUMAN) -  Neuropeptide FF receptor 2 from Homo sapiens

Seq: 522 a.a.

Struc: 293 a.a.

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 343 a.a.*

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 59 a.a.

Protein chain

P63097  (GNAI1_BOVIN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Bos taurus

Seq: 354 a.a.

Struc: 228 a.a.*

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????