PDBsum entry 9m1o

Membrane protein/immune system

PDB id: 9m1o

Contents

Protein chains

293 a.a.

343 a.a.

59 a.a.

233 a.a.

228 a.a.

Ligands

PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2

PDB id:

9m1o

Name:

Membrane protein/immune system

Title:

Cryo-em structures of npffr2 complex with neuropeptide ff

Structure:

Soluble cytochrome b562,neuropeptide ff receptor 2, neuropeptide ff receptor 2. Chain: r. Synonym: g-protein coupled receptor 74,g-protein coupled receptor hlwar77,neuropeptide g-protein coupled receptor. Engineered: yes. Other_details: the chimera protein contains fusion protein bril at n- terminal,the chimera protein contains fusion protein bril at n- terminal,the chimera protein contains fusion protein bril at n-

Source:

Escherichia coli, homo sapiens. Human. Organism_taxid: 562, 9606. Gene: cybc, npffr2, gpr74, npff2, npgpr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Rattus norvegicus. Norway rat. Organism_taxid: 10116.

Authors:

B.X.Pan,X.Z.Li,Y.Jiang

Key ref:

X.Z.Li et al. Structural basis of peptide recognition and modulatio neuropeptide ff receptors. To be published, . PubMed id: 40839429

Date:

26-Feb-25 Release date: 23-Jul-25

Protein chain

Q9Y5X5  (NPFF2_HUMAN) -  Neuropeptide FF receptor 2 from Homo sapiens

Seq: 522 a.a.

Struc: 293 a.a.

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 343 a.a.*

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 59 a.a.

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 228 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????