PDBsum entry 9kpd

Signaling protein

PDB id: 9kpd

Contents

Protein chains

239 a.a.

341 a.a.

57 a.a.

128 a.a.

270 a.a.

Ligands

SA0

PDB id:

9kpd

Name:

Signaling protein

Title:

Cryo-em structure of gpcr16-minigs complex

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(t) subunit alpha- 3. Chain: a. Fragment: gs-gt chimeric,gs-gt chimeric. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Other_details: author stated that the map submitted was automatically

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Homo sapiens, streptococcus pneumoniae.

Authors:

X.Wang,L.J.Wu,T.Hua,Z.J.Liu

Key ref:

X.Wang et al. Cryo-Em structure of gpcr16-Minigs complex. To be published, . PubMed id: 40261795

Date:

22-Nov-24 Release date: 02-Apr-25

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 239 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 341 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

Protein chain

Q9NYV7  (T2R16_HUMAN) -  Taste receptor type 2 member 16 from Homo sapiens

Seq: 291 a.a.

Struc: 270 a.a.*

* PDB and UniProt seqs differ at 24 residue positions (black crosses)

Enzyme reactions

• Enzyme class 1: Chain A: E.C.3.6.5.- - ?????
• Enzyme class 2: Chain R: E.C.3.2.1.18 - exo-alpha-sialidase.
• Reaction: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.