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PDBsum entry 9kfj

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protein ligands Protein-protein interface(s) links
Structural protein/immune system PDB id
9kfj

 

 

 

 

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Contents
Protein chains
295 a.a.
55 a.a.
224 a.a.
230 a.a.
338 a.a.
Ligands
IYF
PDB id:
9kfj
Name: Structural protein/immune system
Title: Cryo-em structure of the compound 4-bound human relaxin family peptide receptor 3 (rxfp3)-gi complex
Structure: Soluble cytochrome b562,relaxin-3 receptor 1,lgbit. Chain: c. Synonym: cytochrome b-562,rln3 receptor 1,g protein-coupled receptor salpr,g-protein coupled receptor gpcr135,relaxin family peptide receptor 3,somatostatin- and angiotensin-like peptide receptor. Engineered: yes. Mutation: yes. Other_details: bril. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit
Source: Escherichia coli, homo sapiens, synthetic construct. Human. Organism_taxid: 562, 9606, 32630. Gene: cybc, rxfp3, gpcr135, rln3r1, salpr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Organism_taxid: 9606.
Authors: Y.Chen,Q.T.Zhou,S.Y.Yan,J.H.Yan,D.H.Yang,J.Chen,M.W.Wang
Key ref: Y.Chen et al. (2025). Molecular mechanism underlying non-Discriminatory recognition of relaxin-3 by rxfp3 and rxfp4.. Commun biol, 8, 794. PubMed id: 40410443 DOI: 10.1038/S42003-025-08220-7
Date:
06-Nov-24     Release date:   13-Aug-25    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli
Seq:
Struc:
128 a.a.
295 a.a.*
Protein chain
Q9NSD7  (RL3R1_HUMAN) -  Relaxin-3 receptor 1 from Homo sapiens
Seq:
Struc:
469 a.a.
295 a.a.
Protein chain
P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens
Seq:
Struc:
71 a.a.
55 a.a.
Protein chain
P04899  (GNAI2_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-2 from Homo sapiens
Seq:
Struc:
355 a.a.
224 a.a.*
Protein chain
No UniProt id for this chain
Struc: 230 a.a.
Protein chain
P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens
Seq:
Struc:
340 a.a.
338 a.a.
Key:    Secondary structure
* PDB and UniProt seqs differ at 121 residue positions (black crosses)

 

 

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