PDBsum entry 9kdg

Membrane protein

PDB id: 9kdg

Contents

Protein chains

800 a.a.

107 a.a.

Ligands

FK5

Metals

_ZN

_CA ×4

_FE

PDB id:

9kdg

Name:

Membrane protein

Title:

Cryoem structure of calcineurin-fusion human endothelin receptor type- b in the ligand-free form

Structure:

Calcineurin-fusion endothelin receptor type-b. Chain: a. Engineered: yes. Peptidyl-prolyl cis-trans isomerase fkbp1b. Chain: f. Synonym: ppiase fkbp1b,12.6 kda fk506-binding protein,12.6 kda fkbp, fkbp-12.6,fk506-binding protein 1b,fkbp-1b,immunophilin fkbp12.6, rotamase,h-fkbp-12. Engineered: yes

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Human. Gene: fkbp1b, fkbp12.6, fkbp1l, fkbp9, otk4. Expressed in: escherichia coli. Expression_system_taxid: 562

Authors:

W.Shihoya,H.Akasaka,O.Nureki

Key ref:

W.Shihoya et al. (2025). Structure of a lasso peptide bound et b receptor prov insights into the mechanism of gpcr inverse agonism.. Nat commun, 16, 3446. PubMed id: 40263271

Date:

03-Nov-24 Release date: 07-May-25

Protein chain

No UniProt id for this chain

Struc: 800 a.a.

Protein chain

P68106  (FKB1B_HUMAN) -  Peptidyl-prolyl cis-trans isomerase FKBP1B from Homo sapiens

Seq: 108 a.a.

Struc: 107 a.a.

Enzyme reactions

• Enzyme class: Chain F: E.C.5.2.1.8 - peptidylprolyl isomerase.
• Reaction: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site