|
|
||
|
|
|
|
|
UniProt functional annotation for P68106 | ||
|
|
|
|
|
|
||
| UniProt code: P68106. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
|
||
| Catalytic activity: | |
Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; |
| Activity regulation: | |
Inhibited by both FK506 and rapamycin. |
| Subunit: | |
Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with RYR2. {ECO:0000269|PubMed:10830164}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. Sarcoplasmic reticulum {ECO:0000250}. |
| Tissue specificity: | |
Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus. {ECO:0000269|PubMed:10830164}. |
| Similarity: | |
Belongs to the FKBP-type PPIase family. FKBP1 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.