PDBsum entry 9jkq

Signaling protein

PDB id: 9jkq

Contents

Protein chains

235 a.a.

339 a.a.

57 a.a.

128 a.a.

296 a.a.

Ligands

B40

PDB id:

9jkq

Name:

Signaling protein

Title:

Cryo-em structure of the meth-bound htaar1-gs complex

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnb1. Gene: gng2. Escherichia coli, homo sapiens.

Authors:

Y.Lin,J.Wang,F.Shi

Key ref:

Y.Lin et al. Molecular mechanisms of methamphetamine-Induced addic via taar1 activation.. J med chem, . PubMed id: 39358311

Date:

16-Sep-24 Release date: 16-Oct-24

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 235 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 296 a.a.*

Protein chain

Q96RJ0  (TAAR1_HUMAN) -  Trace amine-associated receptor 1 from Homo sapiens

Seq: 339 a.a.

Struc: 296 a.a.*

* PDB and UniProt seqs differ at 126 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????