PDBsum entry 9jfy

Membrane protein

PDB id: 9jfy

Contents

Protein chains

298 a.a.

12 a.a.

205 a.a.

335 a.a.

54 a.a.

230 a.a.

PDB id:

9jfy

Name:

Membrane protein

Title:

Cryo-em structure of neuropeptide ff receptor 2 in complex with hnpsf and gi

Structure:

Isoform 2 of neuropeptide ff receptor 2. Chain: r. Synonym: g-protein coupled receptor 74,g-protein coupled receptor hlwar77,neuropeptide g-protein coupled receptor. Engineered: yes. Neuropeptide sf. Chain: l. Synonym: npsf. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: npffr2, gpr74, npff2, npgpr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Gene: gnai1. Gene: gnb1.

Authors:

J.Kim,H.-J.Choi

Key ref:

J.Kim et al. Structural insights into the selective recognition of rf-Amide peptides by neuropeptide ff receptor 2.. Embo rep, . PubMed id: 40128413

Date:

05-Sep-24 Release date: 09-Apr-25

Protein chain

Q9Y5X5  (NPFF2_HUMAN) -  Neuropeptide FF receptor 2 from Homo sapiens

Seq: 522 a.a.

Struc: 298 a.a.

Protein chain

O15130  (NPFF_HUMAN) -  Pro-FMRFamide-related neuropeptide FF from Homo sapiens

Seq: 113 a.a.

Struc: 12 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 205 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 335 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 54 a.a.

Protein chain

No UniProt id for this chain

Struc: 230 a.a.

* PDB and UniProt seqs differ at 36 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????