PDBsum entry 9ik9

Membrane protein

PDB id: 9ik9

Contents

Protein chains

217 a.a.

336 a.a.

53 a.a.

232 a.a.

283 a.a.

Ligands

4J2-DCY-DTY-DTR-LYS-DVA-DCY-ALO-NH2

PDB id:

9ik9

Name:

Membrane protein

Title:

Cryo-em structure of sst analogs bond sstr1-gi complex

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Synthetic construct.

Authors:

T.S.Wong,Z.C.Zeng,T.T.Xiong,S.Y.Gan,Y.Du

Key ref:

Z.Zeng et al. Structural insights into the binding modes of lanreot pasireotide with somatostatin receptor 1. Acta pharm sin b, . PubMed id: 40487642

Date:

26-Jun-24 Release date: 30-Apr-25

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 217 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 336 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 53 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Protein chain

P30872  (SSR1_HUMAN) -  Somatostatin receptor type 1 from Homo sapiens

Seq: 391 a.a.

Struc: 283 a.a.

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????