PDBsum entry 9ebi

Membrane protein

PDB id: 9ebi

Contents

Protein chains

267 a.a.

227 a.a.

339 a.a.

55 a.a.

128 a.a.

Ligands

Q8L

PDB id:

9ebi

Name:

Membrane protein

Title:

Human adenosine a3 receptor gi complex (mini-gsi chimera) bound to piclidenoson (cf101, ib-meca)

Structure:

Adenosine receptor a3. Chain: r. Engineered: yes. Mini-gs/i chimera. Chain: a. Engineered: yes. Other_details: gs-mini-gi1 chimera. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: adora3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Lama glama.

Authors:

L.Zhang,J.I.Mobbs,A.Glukhova,D.M.Thal

Key ref:

L.Zhang et al. (2025). Molecular basis of ligand binding and receptor activa the human a 3 adenosine receptor.. Nat commun, 16, 7674. PubMed id: 40825947 DOI: 10.1038/S41467-025-62872-X

Date:

12-Nov-24 Release date: 20-Aug-25

Protein chain

P0DMS8  (AA3R_HUMAN) -  Adenosine receptor A3 from Homo sapiens

Seq: 318 a.a.

Struc: 267 a.a.

Protein chain

No UniProt id for this chain

Struc: 227 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.