PDBsum entry 8zd1

Membrane protein/immune system

PDB id: 8zd1

Contents

Protein chains

238 a.a.

338 a.a.

52 a.a.

281 a.a.

231 a.a.

PDB id:

8zd1

Name:

Membrane protein/immune system

Title:

Cryo-em structure of the xgpr4-gs complex in ph6.2

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Xenopus tropicalis.

Authors:

N.K.Rong,X.Wen,F.Yang,J.P.Sun

Key ref:

X.Wen et al. (2025). Evolutionary study and structural basis of proton sen mus gpr4 and xenopus gpr4.. Cell, 188, 653. PubMed id: 39753131 DOI: 10.1016/J.CELL.2024.12.001

Date:

30-Apr-24 Release date: 26-Feb-25

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 238 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 52 a.a.

Protein chain

A0A6I8PUB9  () -  G-protein coupled receptor 4 from Xenopus tropicalis

Seq: 353 a.a.

Struc: 281 a.a.*

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

* PDB and UniProt seqs differ at 60 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????