PDBsum entry 8wc6

Membrane protein

PDB id: 8wc6

Contents

Protein chains

227 a.a.

336 a.a.

123 a.a.

267 a.a.

232 a.a.

56 a.a.

Ligands

PEA

PDB id:

8wc6

Name:

Membrane protein

Title:

Cryo-em structure of the pea-bound mtaar1-gs complex

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Synthetic construct. Organism_taxid: 32630. Mus musculus.

Authors:

N.K.Rong,L.L.Guo,M.H.Zhang,Q.Li,F.Yang,J.P.Sun

Key ref:

P.Shang et al. (2023). Structural and signaling mechanisms of taar1 enabled preferential agonist design.. Cell, 186, 5347. PubMed id: 37963465

Date:

11-Sep-23 Release date: 27-Dec-23

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 227 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 227 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 336 a.a.

Protein chain

No UniProt id for this chain

Struc: 123 a.a.

Protein chain

Q923Y8  (TAAR1_MOUSE) -  Trace amine-associated receptor 1 from Mus musculus

Seq: 332 a.a.

Struc: 267 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

* PDB and UniProt seqs differ at 201 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????