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PDBsum entry 8tu3
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Transferase/inhibitor
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PDB id
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8tu3
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PDB id:
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| Name: |
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Transferase/inhibitor
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Title:
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Bruton's tyrosine kinase in complex with covalent inhibitor compound 10
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Structure:
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Tyrosine-protein kinase btk. Chain: a. Fragment: protein kinase domain residues 382-659. Synonym: agammaglobulinemia tyrosine kinase,atk,b-cell progenitor kinase,bpk,bruton tyrosine kinase. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
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Resolution:
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1.70Å
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R-factor:
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0.230
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R-free:
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0.277
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Authors:
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C.M.Metrick
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Key ref:
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M.K.Himmelbauer
et al.
(2024).
Discovery and preclinical characterization of biib129 covalent, Selective, And brain-Penetrant btk inhibito the treatment of multiple sclerosis..
J.Med.Chem.,
67,
8122.
PubMed id:
DOI:
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Date:
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15-Aug-23
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Release date:
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26-Jun-24
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PROCHECK
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Headers
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References
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Q06187
(BTK_HUMAN) -
Tyrosine-protein kinase BTK from Homo sapiens
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Seq:
Struc:
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659 a.a.
256 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class:
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E.C.2.7.10.2
- non-specific protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
