PDBsum entry 8s93

Transferase

PDB id: 8s93

Contents

Protein chain

429 a.a.

Ligands

9AJ

GOL

Metals

_ZN

Waters ×178

PDB id:

8s93

Name:

Transferase

Title:

Crystal structure of the ph-th/kinase complex of bruton's tyrosine kinase

Structure:

Tyrosine-protein kinase btk. Chain: a. Fragment: phth domain residues 1-171 and kinase domain residues 396- 659. Synonym: agammaglobulinemia tyrosine kinase,atk,b-cell progenitor kinase,bpk,bruton tyrosine kinase,kinase emb. Engineered: yes. Mutation: yes

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Gene: btk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.10Å R-factor: 0.201 R-free: 0.247

Authors:

D.Y.Lin,A.H.Andreotti

Key ref:

D.Y.Lin and a.h.andreotti Crystal structure of the ph-Th/kinase complex of brut tyrosine kinase. To be published, . PubMed id: 38189455

Date:

27-Mar-23 Release date: 16-Aug-23

Protein chain

P35991  (BTK_MOUSE) -  Tyrosine-protein kinase BTK from Mus musculus

Seq: 659 a.a.

Struc: 429 a.a.*

* PDB and UniProt seqs differ at 12 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site