PDBsum entry 8iys

Membrane protein

PDB id: 8iys

Contents

Protein chains

355 a.a.

332 a.a.

231 a.a.

55 a.a.

296 a.a.

Ligands

GDP

YN9

PDB id:

8iys

Name:

Membrane protein

Title:

Tug891-bound ffar4 in complex with gq

Structure:

Guanine nucleotide-binding protein g(q) subunit alpha. Chain: a. Synonym: guanine nucleotide-binding protein alpha-q. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnaq, gaq. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Gene: ffar4, gpr120, gpr129, o3far1, pgr4.

Authors:

Y.He,H.Yin

Key ref:

H.Yin et al. Structural basis of omega-3 fatty acid receptor ffar4 activation and g protein coupling selectivity.. Cell res, . PubMed id: 37286793

Date:

06-Apr-23 Release date: 21-Jun-23

Protein chain

P50148  (GNAQ_HUMAN) -  Guanine nucleotide-binding protein G(q) subunit alpha from Homo sapiens

Seq: 359 a.a.

Struc: 355 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 332 a.a.

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

Q5NUL3  (FFAR4_HUMAN) -  Free fatty acid receptor 4 from Homo sapiens

Seq: 361 a.a.

Struc: 296 a.a.

* PDB and UniProt seqs differ at 20 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????