PDBsum entry 8f1h

Transferase/transferase inhibitor

PDB id: 8f1h

Contents

Protein chain

307 a.a.

Ligands

X9H

CIT

Waters ×11

PDB id:

8f1h

Name:

Transferase/transferase inhibitor

Title:

Egfr kinase in complex with tas6417 (cln-081)

Structure:

Epidermal growth factor receptor. Chain: a. Fragment: kinase domain. Synonym: proto-oncogenE C-erbb-1,receptor tyrosine-protein kinase erbb-1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9

Resolution:

2.80Å R-factor: 0.186 R-free: 0.212

Authors:

T.S.Beyett,M.J.Eck

Key ref:

T.S.Beyett and m.j.eck Egfr kinase in complex with tas6417 (cln-081). To be published, . PubMed id: 39471218

Date:

05-Nov-22 Release date: 08-Nov-23

Protein chain

P00533  (EGFR_HUMAN) -  Epidermal growth factor receptor from Homo sapiens

Seq: 1210 a.a.

Struc: 307 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site