PDBsum entry 8ejb

Transferase

PDB id: 8ejb

Contents

Protein chain

270 a.a.

Ligands

WKC

EDO ×2

Metals

_CL

_PD

Waters ×298

PDB id:

8ejb

Name:

Transferase

Title:

Bruton's tyrosine kinase in complex with 3-{[4-(1-acetylpiperidin-4- yl)phenyl]amino}-5-[(3r)-3-(3-methyl-2-oxoimidazolidin-1-yl) piperidin-1-yl]pyrazine-2-carboxamide

Structure:

Tyrosine-protein kinase btk. Chain: a. Synonym: agammaglobulinemia tyrosine kinase,atk,b-cell progenitor kinase,bpk,bruton tyrosine kinase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

1.58Å R-factor: 0.169 R-free: 0.191

Authors:

S.Gajewski,M.C.Clifton

Key ref:

D.Zhang et al. -----Nrx-0492 degrades wildtype and c481 mutant btk a demonstrates in vivo activity in cll patient derived xenografts.. Blood, . PubMed id: 36375120

Date:

16-Sep-22 Release date: 15-Feb-23

Protein chain

Q06187  (BTK_HUMAN) -  Tyrosine-protein kinase BTK from Homo sapiens

Seq: 659 a.a.

Struc: 270 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site