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PDBsum entry 8bsu
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Membrane protein
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PDB id
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8bsu
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PDB id:
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| Name: |
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Membrane protein
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Title:
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Crystal structure of the kainate receptor gluk3-h523a ligand binding domain in complex with kainate and the positive allosteric modulator bpam344 at 2.9a resolution
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Structure:
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Glutamate receptor ionotropic, kainate 3. Chain: a, b, c, d, e, f, g, h. Synonym: gluk3,glutamate receptor 7,glur-7,glur7. Engineered: yes. Mutation: yes. Other_details: the protein crystallized is the extracellular ligand binding domain of gluk3-h523a. Transmembrane regions were genetically removed and replaced with a gly-thr linker (residues 119 and 120 of the structure). Therefore, the sequence matches discontinuously with
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Source:
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Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: grik3, glur7. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.90Å
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R-factor:
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0.208
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R-free:
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0.235
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Authors:
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R.Venskutonyte,K.Frydenvang,J.S.Kastrup
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Key ref:
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Y.Bay
et al.
Positive allosteric modulation of homomeric kainate receptors gluk1-3.
To be published,
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PubMed id:
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Date:
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26-Nov-22
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Release date:
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13-Dec-23
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PROCHECK
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Headers
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References
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P42264
(GRIK3_RAT) -
Glutamate receptor ionotropic, kainate 3 from Rattus norvegicus
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Seq:
Struc:
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919 a.a.
252 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Links
