PDBsum entry 8zsp

Membrane protein/immune system

PDB id: 8zsp

Contents

Protein chains

230 a.a.

338 a.a.

57 a.a.

127 a.a.

281 a.a.

Ligands

7LD

PDB id:

8zsp

Name:

Membrane protein/immune system

Title:

Cryo-em structure of the lsd-bound htaar1-gs complex

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Lama glama. Organism_taxid: 9844.

Authors:

K.X.Jiang,Y.Zheng,F.Xu

Key ref:

K.Jiang et al. (2024). The versatile binding landscape of the taar1 pocket f and other antipsychotic drug molecules.. Cell rep, 43, 14505. PubMed id: 39002128

Date:

05-Jun-24 Release date: 24-Jul-24

Protein chain

P04899  (GNAI2_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-2 from Homo sapiens

Seq: 355 a.a.

Struc: 230 a.a.*

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 230 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 127 a.a.

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 281 a.a.*

Protein chain

Q96RJ0  (TAAR1_HUMAN) -  Trace amine-associated receptor 1 from Homo sapiens

Seq: 339 a.a.

Struc: 281 a.a.

* PDB and UniProt seqs differ at 323 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????