PDBsum entry 8zps

Membrane protein

PDB id: 8zps

Contents

Protein chains

208 a.a.

335 a.a.

228 a.a.

55 a.a.

21 a.a.

289 a.a.

PDB id:

8zps

Name:

Membrane protein

Title:

Cryo-em structure of prolactin-releasing peptide recognition with gi

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha-1. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes. Scfv16. Chain: e.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Gene: prlh, prh. Gene: prlhr, gpr10, gr3.

Authors:

L.Zhao,Y.Li,Q.Yuan,H.E.Xu

Key ref:

Y.Li et al. (2024). Molecular mechanism of prolactin-Releasing peptide recognition and signaling via its g protein-Coupled receptor.. Cell discov, 10, 91. PubMed id: 39223120

Date:

31-May-24 Release date: 25-Sep-24

Protein chain

No UniProt id for this chain

Struc: 208 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 335 a.a.

Protein chain

No UniProt id for this chain

Struc: 228 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

P81277  (PRRP_HUMAN) -  Prolactin-releasing peptide from Homo sapiens

Seq: 87 a.a.

Struc: 21 a.a.*

Protein chain

P49683  (PRLHR_HUMAN) -  Prolactin-releasing peptide receptor from Homo sapiens

Seq: 370 a.a.

Struc: 289 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)